Recombinant Mouse HSPA5 Protein (20-655 aa), His-tagged

• Cat.No.: HSPA5-2010M
• Product Overview: Recombinant Mouse HSPA5 Protein (20-655 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Tags & Cell Markers. Protein Description: Full Length of Mature Protein.

Specification

• Description: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate (By similarity).
• Source: Yeast
• Species: Mouse
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 72.5 kDa
• Protein length: 20-655 aa
• AA Sequence: EEEDKKEDVGTVVGIDLGTTYSCVG VFKNGRVEIIANDQGNRITPSYVAF TPEGERLIGDAAKNQLTSNPENTVF DAKRLIGRTWNDPSVQQDIKFLPFK VVEKKTKPYIQVDIGGGQTKTFAPE EISAMVLTKMKETAEAYLGKKVTHA VVTVPAYFNDAQRQATKDAGTIAGL NVMRIINEPTAAAIAYGLDKREGEK NILVFDLGGGTFDVSLLTIDNGVFE VVATNGDTHLGGEDFDQRVMEHFIK LYKKKTGKDVRKDNRAVQKLRREVE KAKRALSSQHQARIEIESFFEGEDF SETLTRAKFEELNMDLFRSTMKPVQ KVLEDSDLKKSDIDEIVLVGGSTRI PKIQQLVKEFFNGKEPSRGINPDEA VAYGAAVQAGVLSGDQDTGDLVLLD VCPLTLGIETVGGVMTKLIPRNTVV PTKKSQIFSTASDNQPTVTIKVYEG ERPLTKDNHLLGTFDLTGIPPAPRG VPQIEVTFEIDVNGILRVTAEDKGT GNKNKITITNDQNRLTPEEIERMVN DAEKFAEEDKKLKERIDTRNELESY AYSLKNQIGDKEKLGGKLSSEDKET MEKAVEEKIEWLESHQDADIEDFKA KKKELEEIVQPIISKLYGSGGPPPT GEEDTSEKDEL
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: Hspa5 heat shock protein 5 [ Mus musculus ]
• Official Symbol: HSPA5
• Synonyms: HSPA5; GRP-78; XAP-1 antigen; Bip; Sez7; mBiP; Grp78; SEZ-7; Hsce70; AL022860; AU019543; D2Wsu17e; D2Wsu141e
• Gene ID: 14828
• mRNA Refseq: NM_001163434
• Protein Refseq: NP_001156906
• UniProt ID: P20029

Reviews

07/02/2022

This level of support ensures that researchers have a seamless experience, enabling them to focus on their research goals without worrying about logistical or technical concerns.

01/18/2020

Its versatility in various biological applications, along with its compatibility with different techniques, strongly recommend it as a preferred reagent for researchers in the field.

07/07/2019

researchers highly appreciate HSPA5 protein for its excellent performance in ELISA assays and protein electron microscopy structure analysis.

Q&As

Are there drugs targeting HSPA5 currently in development?

Some studies explore small molecules and compounds that target HSPA5 as potential therapeutic agents, but clinical applications are still under investigation.

In what other medical conditions is HSPA5 relevant?

HSPA5 is involved in various conditions, including cardiovascular diseases, diabetes, and neurodegenerative disorders.

Are there diagnostic applications of HSPA5 in cancer?

Elevated levels of HSPA5 in certain cancers may serve as a diagnostic marker, providing information about the cellular stress response and potential malignancy.

Is there a relationship between HSPA5 and autoimmune disorders?

HSPA5's involvement in the immune response suggests potential links to autoimmune disorders, but specific mechanisms are still being studied.

How does HSPA5 influence the immune response?

HSPA5 is involved in antigen presentation, linking its role in protein folding to the modulation of immune responses.