il24
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  • Official Full Name
  • interleukin 24
  • Background
  • This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
  • Synonyms
  • IL24; interleukin 24; ST16; interleukin-24; C49A; FISP; IL 4 induced secreted protein; IL 24; IL10B; mda 7; melanoma differentiation association protein 7; Mob 5; suppression of tumorigenicity 16 (melanoma differentiation); melanocyte-associated Mda-7; IL
Cat.#:IL24-553HTag:MIgG1 Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL24 Protein (Met1-Leu207), MIgG1 Fc-tagged
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Cat.#:IL24-1925HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL24 Protein, MYC/DDK-tagged
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Cat.#:IL24-5211HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IL24 Protein, GST-tagged
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Cat.#:Il24-194RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il24 Protein, His/GST-tagged
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Cat.#:IL24-14189HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL24, GST-tagged
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Cat.#:IL24-380HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL24, His tagged
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Cat.#:IL24-584HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL24, MIgG2a Fc-tagged
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Cat.#:IL24-585HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL24, HIgG1 Fc-tagged, mutant
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Cat.#:IL24-586HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL24, HIgG1 Fc-tagged
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Cat.#:IL24-589HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL24 protein, His-tagged
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Cat.#:IL24-934HTag:His
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human IL24 Protein, His-tagged
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Cat.#:Il24-796MTag:
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Il24
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Cat.#:IL24-8158MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IL24 Protein
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Cat.#:IL24-3042RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IL24 Protein
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Cat.#:Il24-30RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il24 protein, His-tagged
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Cat.#:IL24-276HTag:N/A
Source (Host):S. cerevisiaeSpecies:Human
Product nameRecombinant Human Interleukin 24
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Cat.#:IL24-1922HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL24 cell lysate
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Involved Pathway

IL24 involved in several pathways and played different roles in them. We selected most pathways IL24 participated on our site, such as Cytokine-cytokine receptor interaction, IL23-mediated signaling events, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL24 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
XCL1; CXCL13; Pdgfa&Pdgfb; GDF5; IRX1; CXCL9; CRLF2; TNFRSF10B; LTA; NGFR
IL23-mediated signaling events
IL24; IL17F; IL23R
Jak-STAT signaling pathway
IL22RA1; SOCS5; Ifnl2; IL15; LEPB; SOS1; GM-CSF; IL9; PRP2; BCL2
Senescence and Autophagy
COL10A1; AMBRA1; IFI16; SLC39A3; ING1; CREG1; SLC39A2; ATG7; UVRAG; IGFBP5

Protein Function

IL24 has several biochemical functions, for example, cytokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL24 itself. We selected most functions IL24 had, and list some proteins which have the same functions with IL24. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein CCL19A.1; IL31; IL20; GDF15; IFNA2; TNFSF12; Il2; IFNA1; IFNPHI1; ADIPOQ
Function protein binding
Related Protein GABPA; RTN4A; RGS7BP; COMMD7; MRM1; KIFC3; SLC11A2; CNGA1; GDNF; DAO

Interacting Protein

IL24 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL24 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL24.
CHEK2; PARP1; RAD51; ATM; HMMR; BAG4; HRAS; KRAS; RARG; APC; AKT1; LSP1; PIK3CA; CCR5; PTEN

IL24 Related Articles

Xu, J; Mo, YW; et al. Conditionally replicative adenovirus-based mda-7/IL-24 expression enhances sensitivity of colon cancer cells to 5-fluorouracil and doxorubicin. JOURNAL OF GASTROENTEROLOGY 48:203-213(2013).
Bakshi, S; Zhang, X; et al. Transcriptome analyses in normal prostate epithelial cells exposed to low-dose cadmium: Oncogenic and immunomodulations involving the action of tumor necrosis factor. ENVIRONMENTAL HEALTH PERSPECTIVES 116:769-776(2008).

IL24 Related Gene Family

IL