Recombinant Human IL24 Protein, His-tagged

Cat.No. : IL24-934H
Product Overview : Recombinant Human IL24, transcript variant 1, fused with His tag at C-terminal was expressed in CHO cells.
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Description : This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Source : CHO cells
Tag : His
Form : Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer, 100mM NaCl, pH 7.2
Molecular Mass : 18.9 kDa
AA Sequence : QEFHFGPCQVKGVVPQKLWEAFWAV KDTMQAQDNITSARLLQQEVLQNVS DAESCYLVHTLLEFYLKTVFKNYHN RTVEVRTLKSFSTLANNFVLIVSQL QPSQENEMFSIRDSAHRRFLLFRRA FKQLDVEAALTKALGEVDILLTWMQ KFYKLHHHHHH
Endotoxin : Endotoxin level is <0.1 ng/µg of protein (<1EU/µg).
Purity : >95% as determined by SDS-PAGE and Coomassie blue staining
Concentration : Resuspend the protein in the desired concentration in proper buffer
Gene Name : IL24 interleukin 24 [ Homo sapiens ]
Official Symbol : IL24
Synonyms : IL24; interleukin 24; ST16; interleukin-24; C49A; FISP; IL 4 induced secreted protein; IL 24; IL10B; mda 7; melanoma differentiation association protein 7; Mob 5; suppression of tumorigenicity 16 (melanoma differentiation); melanocyte-associated Mda-7; IL-4-induced secreted protein; melanoma differentiation-associated gene 7 protein; MDA7; MOB5;
Gene ID : 11009
mRNA Refseq : NM_001185156
Protein Refseq : NP_001172085
MIM : 604136
UniProt ID : Q13007

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Are there side effects of Il24? 12/31/2022

The current study shows that the side effects of Il24 are relatively small, and mainly reflected in local reactions, allergic reactions, etc.

Is Il24 safer and more effective than other treatments? 05/22/2022

The safety and efficacy of Il24 need to be validated through more clinical studies, and the safety and efficacy of specific applications need to be evaluated based on individual patient differences.

Which molecules does Il24 interact with? 07/18/2021

Il24 interacts with IL20 receptor complex, IL22 protein, etc.

How does Il24 interfere with the immune system? 08/31/2020

It mainly regulates or interferes with the relevant processes of the immune system by inhibiting some mediators secreted by immune cells, such as cytokines and chemokines.

What are the advantages of Il24 application? 02/27/2020

Il24 has good biological activity, stability and repeatability, and can be large-scale produced by genetic engineering technology, which has potential drug development and application prospects.

Can recombinant Il24 be used to treat tumors? 09/29/2019

Yes, Il24 has been shown to treat many types of solid tumors, including brain glioma, melanoma, lung cancer, prostate cancer, and more.

Customer Reviews (3)

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Reviews
07/07/2022

    Very high quality, very reliable.

    02/03/2021

      Very pure, safe to use.

      11/17/2019

        High stability, can be stored for a long time.

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