Recombinant Human Interleukin 24

Cat.No. : IL24-276H
Product Overview : Recombinant Human Interleukin-3 produced inSaccharomyces cerevisiaeis a single, glycosylated polypeptide chain containing 158 amino acids and having a molecular mass of 18 kDa. As a result of glycosilation, the protein migrates at 19.5 kDa on SDS-PAGE.
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Cat. No. : IL24-276H
Description : IL24 is a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. IL-10B encoded can induce apoptosis selectively in various cancer cells. Overexpression IL-24 leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14, and heat shock 27kDa protein 1 are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes.
Source : Saccharomyces cerevisiae.
Physical Appearance : Sterile Filtered white lyophilized (freeze-dried) powder.
Formulation : Lyophilized from a 0.2nm filtered solution in PBS with BSA as a carrier.
Purity : Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Solubility : It is recommended to reconstitute the lyophilized Interleukin-24 in sterile 18Mω-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
Biological Activity : Measured by its ability to bind to the cell receptor of Capan-1 cells line resulted in Stat-3 activation. The ED50 for this effect is typically 1.0 ng/mL.
Stability : Lyophilized MDA7 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MDA-7 Recombinant should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name : IL24 interleukin 24 [ Homo sapiens ]
Synonyms : IL24; interleukin 24; C49A; FISP; MDA7; ST16; IL-24; IL10B; Mob-5; mda-7; interleukin-24;IL-24 splice variant delE3; IL-24 splice variant delE5; suppression of tumorigenicity 16 protein; melanoma differentiation association protein 7; melanoma differentiation-associated gene 7 protein; suppression of tumorigenicity 16 (melanoma differentiation)
Gene ID : 11009
mRNA Refseq : NM_006850
Protein Refseq : NP_006841
MIM : 604136
UniProt ID : Q13007.1
Chromosome Location : 1q32
Pathway : Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
Function : cytokine activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Are there side effects of Il24? 12/31/2022

The current study shows that the side effects of Il24 are relatively small, and mainly reflected in local reactions, allergic reactions, etc.

Is Il24 safer and more effective than other treatments? 05/22/2022

The safety and efficacy of Il24 need to be validated through more clinical studies, and the safety and efficacy of specific applications need to be evaluated based on individual patient differences.

Which molecules does Il24 interact with? 07/18/2021

Il24 interacts with IL20 receptor complex, IL22 protein, etc.

How does Il24 interfere with the immune system? 08/31/2020

It mainly regulates or interferes with the relevant processes of the immune system by inhibiting some mediators secreted by immune cells, such as cytokines and chemokines.

What are the advantages of Il24 application? 02/27/2020

Il24 has good biological activity, stability and repeatability, and can be large-scale produced by genetic engineering technology, which has potential drug development and application prospects.

Can recombinant Il24 be used to treat tumors? 09/29/2019

Yes, Il24 has been shown to treat many types of solid tumors, including brain glioma, melanoma, lung cancer, prostate cancer, and more.

Customer Reviews (3)

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Reviews
07/07/2022

    Very high quality, very reliable.

    02/03/2021

      Very pure, safe to use.

      11/17/2019

        High stability, can be stored for a long time.

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