Active Recombinant Mouse Il24 Protein, His-Tagged

Cat.No. : Il24-01M
Product Overview : Recombinant mouse Il24 Protein, His-tagged was expressed in E. coli cell
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Description : Interleukin-24 (IL-24) is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control in cell survival and proliferation by inducing rapid activation of particular transcription factors called STAT1 and STAT3. This cytokine is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, arthritis, psoriasis and cancer. Several studies have shown that cell death occurs in cancer cells/cell lines following exposure to IL-24. The gene for IL-24 is located on chromosome 1 in humans.
Source : Escherichia coli
Species : Mouse
Tag : His
Form : Lyophilized powder
AA Sequence : MQEFRFGSCQVTGVVLPELWEAFWT VKNTVQTQDDITSIRLLKPQVLRNV SGAESCYLAHSLLKFYLNTVFKNYH SKIAKFKVLRSFSTLANNF
IVIMSQLQPSKDNSMLPISESAHQR FLLFRRAFKQLDTEVALVKAFGEVD ILLTWMQKFYHL with polyhistidine tag at the C-terminus
Endotoxin : <0.1 EU per 1 μg of the protein by the LAL method.
Bio-activity : Measure by its ability to induce proliferation in BaF3 cells transfected with human IL-20 R alpha and human IL-20 R beta. The ED50 for this effect is <0.3 ng/mL.
Purity : >95% as determined by SDS-PAGE. Ni-NTA chromatography
Storage Buffer : The protein was lyophilized from a solution containing 1X PBS, pH 7.4.
Reconstitution : It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
Storage : Lyophilized protein should be stored at -20°C. Upon reconstitution, protein aliquots should be stored at -20°C or -80°C.
Notes : Please use within one month after protein reconstitution.
SDS-PAGE:
Gene Name : Il24 interleukin 24 [ Mus musculus (house mouse) ]
Official Symbol : Il24
Synonyms : FISP; If2e; Mda7; St16; Mda-7
Gene ID : 93672
mRNA Refseq : NM_053095.3
Protein Refseq : NP_444325.3
UniProt ID : A0A087WQD7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Are there side effects of Il24? 12/31/2022

The current study shows that the side effects of Il24 are relatively small, and mainly reflected in local reactions, allergic reactions, etc.

Is Il24 safer and more effective than other treatments? 05/22/2022

The safety and efficacy of Il24 need to be validated through more clinical studies, and the safety and efficacy of specific applications need to be evaluated based on individual patient differences.

Which molecules does Il24 interact with? 07/18/2021

Il24 interacts with IL20 receptor complex, IL22 protein, etc.

How does Il24 interfere with the immune system? 08/31/2020

It mainly regulates or interferes with the relevant processes of the immune system by inhibiting some mediators secreted by immune cells, such as cytokines and chemokines.

What are the advantages of Il24 application? 02/27/2020

Il24 has good biological activity, stability and repeatability, and can be large-scale produced by genetic engineering technology, which has potential drug development and application prospects.

Can recombinant Il24 be used to treat tumors? 09/29/2019

Yes, Il24 has been shown to treat many types of solid tumors, including brain glioma, melanoma, lung cancer, prostate cancer, and more.

Customer Reviews (3)

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Reviews
07/07/2022

    Very high quality, very reliable.

    02/03/2021

      Very pure, safe to use.

      11/17/2019

        High stability, can be stored for a long time.

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