Active Recombinant Mouse Il24 Protein (Gln27-Leu181), C-His tagged, Animal-free, Carrier-free

• Cat.No.: Il24-320M
• Product Overview: Recombinant Mouse Il24 Protein (Gln27-Leu181) with C-His tag was expressed in E. coli and Animal-free as well as Carrier-free.

Specification

• Description: Interleukin 24 (IL-24) predicts a molecular mass of 18.2 kDa, is a cytokine belonging to the IL-10 family of cytokines that signals through IL-20R1 /IL-20R2 and IL-22R1 /IL-20R2. Its normal physiological role is connected with wound healing, protection against diseases caused by bacteria.
• Source: E. coli
• Species: Mouse
• Tag: His
• Form: Lyophilized
• Bio-activity: Measure by its ability to induce proliferation in BaF3 cells transfected with human IL-20 R alpha and human IL-20 R beta. The ED50 for this effect is < 0.3 ng/mL.
• Molecular Mass: The protein has a calculated MW of 18.94 kDa.
  The protein migrates about 17 kDa under reducing condition (SDS-PAGE analysis).
• Protein Length: Gln27-Leu181
• Endotoxin: < 0.1 EU/μg of the protein by the LAL method.
• Purity: >95% as determined by SDS-PAGE analysis.
• Storage: This product is stable after storage at:
  -20 centigrade for 12 months in lyophilized state from date of receipt.
  -20 or -80 centigrade for 1 month under sterile conditions after reconstitution.
  Avoid repeated freeze/thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
• Reconstitution: It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
• Shipping: The product is shipped with polar packs. Upon receipt, store it immediately at -20 centigrade or lower for long term storage.

Gene Information

• Gene Name: Il24 interleukin 24 [ Mus musculus (house mouse) ]
• Official Symbol: Il24
• Synonyms: IL24; interleukin 24; interleukin-24; IL-24; th2-specific cytokine FISP; IL-4-induced secreted protein; melanoma differentiation-associated gene 7 protein; FISP; Mda7; St16; Mda-7
• Gene ID: 93672
• mRNA Refseq: NM_053095
• Protein Refseq: NP_444325
• UniProt ID: Q925J3

Reviews

07/07/2022

Very high quality, very reliable.

02/03/2021

Very pure, safe to use.

11/17/2019

High stability, can be stored for a long time.

Q&As

Are there side effects of Il24?

The current study shows that the side effects of Il24 are relatively small, and mainly reflected in local reactions, allergic reactions, etc.

Is Il24 safer and more effective than other treatments?

The safety and efficacy of Il24 need to be validated through more clinical studies, and the safety and efficacy of specific applications need to be evaluated based on individual patient differences.

Which molecules does Il24 interact with?

Il24 interacts with IL20 receptor complex, IL22 protein, etc.

How does Il24 interfere with the immune system?

It mainly regulates or interferes with the relevant processes of the immune system by inhibiting some mediators secreted by immune cells, such as cytokines and chemokines.

What are the advantages of Il24 application?

Il24 has good biological activity, stability and repeatability, and can be large-scale produced by genetic engineering technology, which has potential drug development and application prospects.

Can recombinant Il24 be used to treat tumors?

Yes, Il24 has been shown to treat many types of solid tumors, including brain glioma, melanoma, lung cancer, prostate cancer, and more.