Recombinant Human IL24 protein, His-tagged
Cat.No. : | IL24-589H |
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Product overview : | Recombinant Human IL24 (Q13007) aa. (Gly51~Leu206) fused with His tag was produced in E. coli cells. |
Description : | This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 19.5kDa; Accurate Molecular Mass: 18kDa as determined by SDS-PAGE reducing conditions. |
Protein length : | Gly51~Leu206 |
Purity : | >92% |
Characteristic : | Isoelectric point is 8.6. |
Applications : | Cell culture; Activity Assays; In vivo assays. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | 20mM Tris, 150mM NaCl, pH8.0, containing 0.05% sarcosyl and 5% trehalose. |
Reconstitution : | Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex |
Gene Name : | IL24 interleukin 24 [ Homo sapiens (human) ] |
Official Symbol : | IL24 |
Synonyms : | IL24; interleukin 24; C49A; FISP; MDA7; MOB5; ST16; IL10B; interleukin-24; IL-4-induced secreted protein; melanocyte-associated Mda-7; melanoma differentiation-associated gene 7 protein; suppression of tumorigenicity 16 (melanoma differentiation) |
Gene ID : | 11009 |
mRNA Refseq : | NM_001185156.1 |
Protein Refseq : | NP_001172085.1 |
UniProt ID : | Q13007 |
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◆ Lysates | ||
IL24-1922HCL | Recombinant Human IL24 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewVery high quality, very reliable.
Very pure, safe to use.
High stability, can be stored for a long time.
Q&As (6)
Ask a questionThe current study shows that the side effects of Il24 are relatively small, and mainly reflected in local reactions, allergic reactions, etc.
The safety and efficacy of Il24 need to be validated through more clinical studies, and the safety and efficacy of specific applications need to be evaluated based on individual patient differences.
Il24 interacts with IL20 receptor complex, IL22 protein, etc.
It mainly regulates or interferes with the relevant processes of the immune system by inhibiting some mediators secreted by immune cells, such as cytokines and chemokines.
Il24 has good biological activity, stability and repeatability, and can be large-scale produced by genetic engineering technology, which has potential drug development and application prospects.
Yes, Il24 has been shown to treat many types of solid tumors, including brain glioma, melanoma, lung cancer, prostate cancer, and more.
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