irak1
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  • Official Full Name
  • interleukin-1 receptor-associated kinase 1
  • Background
  • Interleukin-1 (IL-1) receptor-associated kinase (IRAK) is a serine/threonine-specific kinase that can be coprecipitated in an IL-1-inducible manner with the IL-1 receptor. The mammalian family of IRAK molecules contains four members (IRAK1, IRAK2, IRAK3/I
  • Synonyms
  • IRAK1; interleukin-1 receptor-associated kinase 1; IRAK; pelle; IRAK-1; Pelle homolog
Cat.#:IRAK1-5056HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IRAK1 Protein, GST-tagged
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Cat.#:IRAK1-5436HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Interleukin-1 Receptor-Associated Kinase 1, GST-tagged
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Cat.#:IRAK1-1542HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IRAK1, His-tagged
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Cat.#:IRAK1-27500THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human IRAK1
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Cat.#:IRAK1-27502THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human IRAK1
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Cat.#:IRAK1-7068HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IRAK1 protein, His-tagged
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Cat.#:IRAK1-5173HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IRAK1 293 Cell Lysate
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Cat.#:IRAK1-5174HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IRAK1 293 Cell Lysate
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Involved Pathway

IRAK1 involved in several pathways and played different roles in them. We selected most pathways IRAK1 participated on our site, such as NF-kappa B signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRAK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
NFKBIA; TNFRSF11A; LY96; NFKB2; BCL2A1; TNF; DDX58; TNFSF11; MAP3K7IP3; TRAF1
Apoptosis
CASP2; TP53; BIRC2; CASP6; PRKAR2AB; DSG3; CAPN2L; BIRC8; IKBKG; PIK3R2
Toll-like receptor signaling pathway
MAPK14B; PIK3CB; MAP2K7; MAP2K4A; IFNA1; IRF3; PIK3R3; CCL4L1; TAB2; TLR2-2
Neurotrophin signaling pathway
FASLG; PRKCD; ARHGDIA; MAPK10; PLCG1; PIK3CB; IRS1; NGF; IRAK4; RPS6KA3
Pertussis
IRAK1; IRF8; CD14; Il23a; Il12b; CALM3; GNAI1; C1QA; NLRP3; CXCL6; MAPK11
Leishmaniasis
HLA-DOA; IL1B; HLA-DPA1; FCGR3; FOS; HLA-DMA; PRKCB; ITGA4; IRAK4; MAPK1
Chagas disease (American trypanosomiasis)
C3; GNA11; CD3E; CD3D; PLCB4; GNAQ; TGFBR1; C1QA; GNAI2; TLR2; TLR4
Toxoplasmosis
HLA-DPA1; PDPK1; ITGA6; MAPK13; AKT2; LY96; MAPK12; CASP9; HSPA8; BCL2
Tuberculosis
IFNA7; BAD; IFNA13; Il23a; IFNA21; HLA-DOA; RFXANK; PIK3C3; LBP; FCER1G
Measles
TNFSF10; TRAF6; CD209B; TRP53; OAS3; CCND2; PIK3R5; OAS1A; CCND1; IFNGR2
Epstein-Barr virus infection
YWHAE; HSPA1B; HLA-DQA1; MDM2; POLR2G; RAN; MAP2K6; HSPB2; MAPK13; TRAF1

Protein Function

IRAK1 has several biochemical functions, for example, ATP binding, NF-kappaB-inducing kinase activity, heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRAK1 itself. We selected most functions IRAK1 had, and list some proteins which have the same functions with IRAK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ACVR2B; RIOK2; PRKCI; EHD1; JAK3; CSNK1G3; CLK1; ACTC1B; ABCD2; LIG4
Function NF-kappaB-inducing kinase activity
Related Protein RIPK3; IRAK1; MAP3K14; IKBKE; ALK; ALPK2; PPP4C
Function heat shock protein binding
Related Protein APAF1; IRAK1; HSPA6; DNAJC9; EEF1D; DNAJA3A; PPID; FAF1; TPR; DNAJA3B
Function interleukin-1 receptor binding
Related Protein TLR5; IL1F10; IRAK1; IL36RN; IL1A; IL1RAP; IL37; Il1f6; TRIP6; IL36B
Function kinase activity
Related Protein CDKN1D; NME2B.1; SRPK1A; FYNA; PFKMB; FGFR1A; CCL3; JAK2B; PKM; PRKCBA
Function protein binding
Related Protein EIF2AK2; MED22; SLC48A1; NAT8; GPR3; TBC1D23; PINX1; AGO2; Itga10&Itgb1; MAT2B
Function protein heterodimerization activity
Related Protein PDGFA; LTC4S; H2AFV; EXT2; CHRNB4; HNF1A; HIST1H2BB; CHUK; HIST1H4G; ABTB2
Function protein homodimerization activity
Related Protein PLCB1; MYPOP; GOLGA5; ADSSL1; WHRN; PYGL; IKBKB; USH2A; GRPEL2; HSD17B4
Function protein kinase activity
Related Protein PRKG1A; DAPK2A; MAPK8A; MINK1; MAP3K4; TEK; RPS6KA5; EPHA1; PLK2B; EGFRA
Function protein serine/threonine kinase activity
Related Protein SGK1; MARK3; PAK2; IRAK3; HIPK3; TSSK1; RAF1; GRK7A; AKT3A; OXSR1B
Function ubiquitin-protein transferase activity
Related Protein TRIM68; MKRN1; MARCH4; TRIM13; TRIM23; TRAF3; UBA7; FLJ11011L; ZYG11B; UBE2D1

Interacting Protein

IRAK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRAK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRAK1.
TRAF6; PELI2; PIN1; MYD88; PELI1

IRAK1 Related Articles

Zhang, JM; Jia, G; et al. Silencing miR-146a influences B cells and ameliorates experimental autoimmune myasthenia gravis. IMMUNOLOGY 144:56-67(2015).
Ciccacci, C; Perricone, C; et al. A Multilocus Genetic Study in a Cohort of Italian SLE Patients Confirms the Association with STAT4 Gene and Describes a New Association with HCP5 Gene. PLOS ONE 9:-(2014).