IRAK1
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Official Full Name
interleukin-1 receptor-associated kinase 1
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Overview
Interleukin-1 (IL-1) receptor-associated kinase (IRAK) is a serine/threonine-specific kinase that can be coprecipitated in an IL-1-inducible manner with the IL-1 receptor. The mammalian family of IRAK molecules contains four members (IRAK1, IRAK2, IRAK3/I -
Synonyms
IRAK1; interleukin-1 receptor-associated kinase 1; IRAK; pelle; IRAK-1; Pelle homolog;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect cell
- Insect Cell
- Sf21
- Wheat Germ
- GST
- His
- Myc
- DDK
- MYC
- N/A
- N
- C
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- IRAK1 Related Articles
- IRAK1 Related Signal Pathway
IRAK1 involved in several pathways and played different roles in them. We selected most pathways IRAK1 participated on our site, such as NF-kappa B signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRAK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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NF-kappa B signaling pathway | PRKCQ;DDX58;LBP;IRAK4;BCL10;LCK;PTGS2;CARD11;MYD88 |
Apoptosis | CDK5RAP2;IL3;PRKACAA;AKT2;AIFM1;CFLAR;CASP6L1;PPP3R1;CASP8L1 |
Toll-like receptor signaling pathway | IRAK1;TLR5B;LY96;AKT3A;MAPK13;TLR9;MAP2K7;IL6;MAP2K4B |
Neurotrophin signaling pathway | YWHAE;FOXO3;MAP3K5;KIDINS220;MAPK13;AKT2;PIK3CD;GRB2;PIK3R1 |
Pertussis | IL12A;ITGB1;MYD88;NFKB1;NOS2;MAPK9;LY96;CXCL6;TNF |
Leishmaniasis | NCF2;IL1B;TGFB3;ELK1;IRAK1;NCF4;HLA-DRB3;MYD88;HLA-DRB4 |
Chagas disease (American trypanosomiasis) | PIK3CG;GNAQ;GNA14;NFKB1;CD3E; CD3D;CCL5;NOS2;TGFB2;IL12A |
Toxoplasmosis | GNAI3;Toxoplasma Gondii Microneme Protein MIC3;HLA-DRA;LDLR;ITGB1;NOS2;HLA-DQB1;HSPA8;HSPA1L |
Tuberculosis | PLK3;CLEC7A;NOS2;ATP6V0A1;IFNA2;BCL10;TLR4;Cd209g;PIK3C3 |
Measles | IRF7;EIF3H;TP53;IFNG;IL4;CD209A;IFNA6;FCGR2B;MAP3K7 |
Epstein-Barr virus infection | NFKBIA;HSPA8;HLA-F;GSK3B;RAN;MAPK11;PSMC1;POLR2F;ICAM1 |
IRAK1 has several biochemical functions, for example, ATP binding, NF-kappaB-inducing kinase activity, heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRAK1 itself. We selected most functions IRAK1 had, and list some proteins which have the same functions with IRAK1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | STK25;RUNX3;TLK1A;CAMK1GB;IDH3G;HSP104;TTLL12;NOD1;CHST13 |
NF-kappaB-inducing kinase activity | RIPK3;ALK;ALPK2;IRAK1;PPP4C;MAP3K14;IKBKE |
heat shock protein binding | SSUH2RS1;EEF1D;FKBP4;KCNJ11;TOMM34;TFAM;DNAJC9;PARK2;BAX |
interleukin-1 receptor binding | IL1RN;IL36B;IL1A;TRIP6;IRAK4;IL1RAP;TLR9;IL37;IL36G |
kinase activity | INSRB;CAMK2B1;NME2B.1;KITB;ALPK2;STK35L;PFKFB4L;EPHB3A;TNK2B |
protein binding | SLC9A1;CEP63;GORASP2;FCGR2A;C1S;SIRPB1;UHRF1;TRP53;HDLBP |
protein heterodimerization activity | MEF2A;UGT1A9;ENO2;HIST1H2AL;JAM2A;SMAD2;KATNA1;HOMER2;POLA2 |
protein homodimerization activity | TG;MAP3K11;TCF3B;ACCS;SPPL2B;ADAM10;SYT6;NTRK1;HIF1AN |
protein kinase activity | PKDCCA;PRKCD;MAP2K2B;SGK196;RLN1;NEK1;RIPK1L;MAP4K6;STK26 |
protein serine/threonine kinase activity | STK11;ADCK1;LRRK1;HIPK1;PINK1;TTN;CDC7;SIK3;MAP4K2 |
ubiquitin-protein transferase activity | FBXO30B;TRAF2;WDSUB1;BIRC2;UBE2N;FBXL14A;UBE2D2A;CNOT4;ANKIB1 |
IRAK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRAK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRAK1.
TRAF6; PELI2; PIN1; MYD88; PELI1
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, there are several clinical trials exploring the inhibition of IRAK1 as a therapeutic strategy for various types of cancer.
IRAK1 is involved in the signaling pathways that can lead to the development of autoimmune diseases by regulating the immune system's response to self-antigens.
Elevated levels of IRAK1 expression have been observed in inflammatory diseases, suggesting its involvement in the dysregulation of inflammatory responses.
Inhibiting IRAK1 activity is being investigated as a potential therapeutic approach for managing inflammatory conditions, offering a target for drug development.
IRAK1 has been identified as a potential target for cancer therapy, as it plays a role in promoting tumor growth and evasion of the immune system.
Customer Reviews (3)
Write a reviewThe IRAK1 protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.
The IRAK1 protein's compatibility with various experimental techniques adds to its versatility.
Its stability and compatibility make it an excellent tool for visualizing and characterizing protein structures at high resolution.
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