IRAK1 Protein, interleukin-1 receptor-associated kinase 1

IRAK1

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IRAK1

Official Full Name interleukin-1 receptor-associated kinase 1
Background Interleukin-1 (IL-1) receptor-associated kinase (IRAK) is a serine/threonine-specific kinase that can be coprecipitated in an IL-1-inducible manner with the IL-1 receptor. The mammalian family of IRAK molecules contains four members (IRAK1, IRAK2, IRAK3/I
Synonyms IRAK1; interleukin-1 receptor-associated kinase 1; IRAK; pelle; IRAK-1; Pelle homolog
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IRAK1-869H Recombinant Human IRAK1 protein, His-tagged Insect cell His
    Mouse Irak1-1243M Recombinant Mouse Irak1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human IRAK1-1542H Recombinant Human IRAK1, His-tagged E.coli His
    Human IRAK1-27500TH Recombinant Human IRAK1 Wheat Germ N/A
    Human IRAK1-27502TH Recombinant Human IRAK1 Wheat Germ N/A
    Human IRAK1-5056H Recombinant Human IRAK1 Protein, GST-tagged Wheat Germ GST
    Human IRAK1-5173HCL Recombinant Human IRAK1 293 Cell Lysate HEK293 N/A
    Human IRAK1-5174HCL Recombinant Human IRAK1 293 Cell Lysate HEK293 N/A
    Human IRAK1-5436H Recombinant Human Interleukin-1 Receptor-Associated Kinase 1, GST-tagged Insect Cell GST
    Human IRAK1-7068H Recombinant Human IRAK1 protein, His-tagged E.coli His

    IRAK1 involved in several pathways and played different roles in them. We selected most pathways IRAK1 participated on our site, such as NF-kappa B signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRAK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway Ccl21a; BCL2A1; BCL10; CCL21B; CCL4; TAB2; LTBR; CD40LG; RELA; MYD88
    Apoptosis CAPN1; CDKN2A; BCL2; PPP3CCB; DSG1; FADD; TICAM1; PRKAR2AB; BAD; CFLAR
    Toll-like receptor signaling pathway IFNA7; AKT3A; MAPK14A; TOLLIP; CD86; PIK3CB; AKT1; IFNA8; CXCL9; Ifna11
    Neurotrophin signaling pathway PRDM4; MAPK10; NFKBIE; RELA; Fasl; ABL1; KRAS; PDPK1; PIK3CG; NFKB1
    Pertussis IRF1; C1R; MYD88; RHOA; IL12A; C3; IRF8; CFL2; SERPING1; ITGB2
    Leishmaniasis IL1A; IRAK4; FCGR1A; ITGB2; NCF4; TRAF6; FCGR2A; PTGS2; TGFB2; CR1
    Chagas disease (American trypanosomiasis) IRAK1; FOS; PIK3CA; TLR9; LOC100033925; TGFBR2; MAPK9; CASP8; TLR2; IL-8
    Toxoplasmosis IRAK4; MAPK10; CASP8; MAPK1; LAMA1; MAP3K7; HLA-DMB; PIK3R1; HLA-DPB1; BIRC7
    Tuberculosis FCGR4; IL12B; ATP6V0C; RAB5C; TNF; HLA-DQA1; IFNA2; TLR1; TRADD; ATP6V0D1
    Measles IFNA10; PIK3R3; IL4; IFNGR2; TNFRSF10D; STAT3; CD3E; CD3D; IFNA6; TNFRSF10B; cgr2b
    Epstein-Barr virus infection CD40; EIF2AK2; PSMC2; POLR2J3; HLA-A; SHFM1; PSMC1; TAB1; SNW1; RIPK1

    IRAK1 has several biochemical functions, for example, ATP binding, NF-kappaB-inducing kinase activity, heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRAK1 itself. We selected most functions IRAK1 had, and list some proteins which have the same functions with IRAK1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PEX6; ATRX; ABCG2D; MYHZ2; PTK2AB; MCCC1; BRIP1; NLRP14; PRKD1; RIPK2
    NF-kappaB-inducing kinase activity PPP4C; IRAK1; ALK; RIPK3; IKBKE; MAP3K14; ALPK2
    heat shock protein binding TPR; PARK2; CDC37; NFKBIA; SSUH2RS1; DNAJA3B; EEF1D; DNAJA3A; LMAN2; SSUH2.2
    interleukin-1 receptor binding IL36RN; IRAK4; IRAK1; IL1B; TRIP6; TLR9; IL36G; Il1f6; IL1F10; IL37
    kinase activity PFKMB; ADKA; PRKACBB; FAM20B; EPHB4B; PANK1A; SBK3; ALPK2; JAK2A; PFKFB4L
    protein binding CSE1L; SSX3; ABCB1; MGAT5B; ASAP3; RASA1; GM5506; IL32; C4BP; ATE1
    protein heterodimerization activity BTBD11; HIST1H3C; TYR; NKX2; JDP2; TAF6L; KCNK3; SOX5; BAD; TCF4
    protein homodimerization activity PYCARD; MYPOP; ECT2; GALE; ERP29; TOX3; GSTM1; TYRP1; BCL2L2; SLC9A7
    protein kinase activity EGFRA; DCLK1; PKN3; EEF2K; SRPK1A; HIPK3B; CDK12; KALRN; PRKAG1; SOX9
    protein serine/threonine kinase activity STK3; AKT1; CDK5; SIK2A; STK40; DCLK1A; TSSK1; ADCK5; MLKL; TAF1L
    ubiquitin-protein transferase activity TRAF5; BIRC2; UBE2D3; SMURF2; TRIM71; FBXO4; ZYG11B; FBXO22; ZNF738; RNF144AB

    IRAK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRAK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRAK1.

    TRAF6; PELI2; PIN1; MYD88; PELI1

    Zhang, JM; Jia, G; et al. Silencing miR-146a influences B cells and ameliorates experimental autoimmune myasthenia gravis. IMMUNOLOGY 144:56-67(2015).
    Ciccacci, C; Perricone, C; et al. A Multilocus Genetic Study in a Cohort of Italian SLE Patients Confirms the Association with STAT4 Gene and Describes a New Association with HCP5 Gene. PLOS ONE 9:-(2014).

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