KLK1
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Official Full Name
kallikrein 1
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Overview
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008] -
Synonyms
KLK1; kallikrein 1; hK1; KLKR; Klk6; kallikrein-1; tissue kallikrein; glandular kallikrein 1; kallikrein serine protease 1; kallikrein 1, renal/pancreas/salivary; kidney/pancreas/salivary gland kallikrein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Human Cell
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Mouse
- P.pastoris
- Rabbit
- Yeast
- C
- 6×His
- His
- GST|His
- His (Fc)
- Avi
- His|GST
- SUMO
- N/A
- N
- No tag
- Background
- Quality Guarantee
- Case Study
- Involved Pathway
- Protein Function
- Interacting Protein
- KLK1 Related Articles
- KLK1 Related Research Area
What is KLK1 protein?
KLK1 protein, also known as tissue kallikrein 1, is an enzyme that is encoded by the KLK1 gene. It belongs to the kallikrein-related peptidase family and is primarily expressed in the kidneys, pancreas, and salivary glands. KLK1 is involved in various physiological processes, including regulation of blood pressure and electrolyte balance.
What is the function of KLK1 protein?
The main function of KLK1 is to catalyze the hydrolysis of kininogens to produce active kinins, particularly bradykinin. Bradykinin is a potent vasodilator that plays a role in regulating blood pressure by promoting the relaxation of blood vessels. KLK1 also exhibits anti-inflammatory properties by inhibiting the formation of pro-inflammatory mediators such as prostaglandins and leukotrienes.
KLK1 related signaling pathway
The signaling pathway of KLK1 is not well-studied or understood compared to other more extensively investigated pathways. However, KLK1 has been shown to have several physiological functions, including regulation of blood pressure, electrolyte balance, and blood coagulation.
KLK1 exerts its effects through the activation of the bradykinin receptor (B2 receptor) pathway. When KLK1 interacts with its substrate kininogen, it generates the vasoactive peptide bradykinin. Bradykinin binds to the B2 receptor, leading to the activation of downstream signaling pathways, such as the PI3K/Akt pathway and the nitric oxide/cyclic GMP pathway. These signaling pathways mediate various biological effects, such as vasodilation, inflammation, and tissue repair.
KLK1 Related Diseases
- Hypertension: A decrease in KLK1 activity can result in impaired vasodilation and increased blood pressure.
- Renal disorders: Altered KLK1 activity may contribute to kidney diseases, such as chronic kidney disease and diabetic nephropathy.
- Fibrosis: KLK1 has been shown to have anti-fibrotic effects, so its deficiency can lead to fibrotic disorders, such as pulmonary fibrosis or liver fibrosis.
- Hypertension: KLK1 has been investigated as a potential treatment for hypertension due to its ability to lower blood pressure. It is being studied as an alternative or adjunct to conventional antihypertensive drugs.
- Acute pancreatitis: KLK1 has been explored as a therapeutic agent for acute pancreatitis, an inflammatory condition of the pancreas. It has been shown to reduce inflammation, oxidative stress, and tissue damage in experimental models.
Biomedical Application of KLK1 Protein
- Hypertension: KLK1 has been investigated as a potential treatment for hypertension due to its ability to lower blood pressure. It is being studied as an alternative or adjunct to conventional antihypertensive drugs.
- Diabetic nephropathy: KLK1 has shown promising effects in preclinical studies for the treatment of diabetic nephropathy, a common complication of diabetes that leads to kidney damage. It has been shown to improve kidney function and reduce proteinuria, a hallmark feature of diabetic nephropathy.
- Acute pancreatitis: KLK1 has been explored as a therapeutic agent for acute pancreatitis, an inflammatory condition of the pancreas. It has been shown to reduce inflammation, oxidative stress, and tissue damage in experimental models.
High Purity
Fig1. SDS-PAGE (KLK1-3138H)
(Melia Magnen, 2019)
Fig2. Kallikrein 1 (KLK1) induces the release of granulocyte-macrophage colony-stimulating factor (GM-CSF). D: differentiated NHBE were treated with active human KLK1 for 6 or 24 h and GM-CSF was quantified in the culture medium by ELISA (n = 4 per group). E: KLK1-dependent release of GM-CSF from A549 alveolar epithelial-like cells treated for 24 h with 50 nM human KLK1 (n = 8). Data points/bars represent means ± SE of the results and are representative of 2 independent experiments.
(Heng Zhong, 2023)
Fig3. The heap map of molecular docking binding energy.
(Z. Tang, 2018)
Fig4. Verification of hKLK1 and rKLK1 expression in the corpus cavernosum. (A) Representative hKLK1 genomic DNA bands from rat corpus cavernosum obtained after conventional PCR, followed by agarose gel electrophoresis. (B) Real‑time RT‑PCR showing the relative mRNA levels of rKLK1 and hKLK1, with β‑actin as the loading control in the corpus cavernosum of the three groups. (C) Representative western blotting results of rKLK1, hKLK1, and β‑actin in the corpus cavernosum of the three groups. (D) The relative rKLK1 and hKLK1 expression (with respect to the β‑actin loading control) in the corpus cavernosum of the three groups are presented as bar graphs.
KLK1 involved in several pathways and played different roles in them. We selected most pathways KLK1 participated on our site, such as Renin-angiotensin system, Endocrine and other factor-regulated calcium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Renin-angiotensin system | ENPEP;KLK1;KLK1B1;KLK1B5;KLK1B3;LNPEP;KLK1B24;AGTR1B;PREP |
| Endocrine and other factor-regulated calcium reabsorption | GNAQ;PLCB2;KLK1;ESR1;SLC8A1;KLK1B24;DNM2;PLCB1;PRKCB |
KLK1 has several biochemical functions, for example, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLK1 itself. We selected most functions KLK1 had, and list some proteins which have the same functions with KLK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase activity | CLPP;CFI;TPSB2;PRSS22;TPSAB1;C1S;F7I;KLK1;PRSS2 |
KLK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLK1.
- Q&As
- Reviews
Q&As (5)
Ask a questionKLK1 participates in the regulation of blood clotting and fibrinolysis by influencing the activation of certain coagulation factors and promoting fibrinolysis.
KLK1 contributes to renal function by promoting vasodilation in the renal blood vessels and influencing sodium and water excretion, which can be beneficial in kidney diseases.
Some studies suggest that KLK1 may be involved in cancer progression, but the relationship is complex and not fully understood. Further research is needed.
Some studies suggest that KLK1-based therapies may have potential in managing inflammatory conditions, but more research is needed for conclusive evidence.
The potential use of KLK1 in cancer therapy is an area of investigation, but no specific KLK1-based cancer therapies have been established yet.
Customer Reviews (3)
Write a reviewWhether measuring analyte concentrations, screening for specific interactions, or monitoring immune responses, this protein's exceptional performance in ELISA experiments is truly commendable.
Its high quality, reliability, and exceptional performance make it an excellent choice for a wide range of experimental applications.
This strong track record of excellence further attests to the KLK1 protein's capability to meet the rigorous demands of research projects.
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