Recombinant Human Kallikrein 1
Cat.No. : | KLK1-38H |
Product Overview : | Recombinant Human KLK1 produced in Yeast is a single, glycosylated, polypeptide chain containing 238 amino acids and having a molecular mass of 28-32 kDa. KLK1 Human Recombinant is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | KLK1-38H |
Description : | KLK1 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. KLK1 is functionally conserved in its ability to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. Human Kallikrein-1, also called as Kallidinogenase, Kininogenase or Kininogenin, is an active protein enzyme present in saliva, pancreatic juices, and urine that catalyzes the proteolysis of bradykininogen to bradykinin. Kallikrein-1, which derived from human or porcine, have been used as drugs for a long time, they are mainly used in the treatment f light to medium hypertension and occlusion of cerebral and surrounding blood vessels. KLK1 demonstrates both trypsin- and chymotrypsin-like selectivities with Tyr/Arg preferred at site P1, Ser/Arg strongly preferred at P1", and Phe/Leu at P2. |
Source : | Pichia Pastoris |
Amino Acid Sequence : | The sequence of the first five N-terminal amino acids was determined and was found to be Ile-Val-Gly-Gly-Trp-Glu. |
Physical Appearance : | Sterile Filtered clear solution. |
Purity : | Greater than 98.0% as determined by both: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Formulation : | The protein solution contains 1X PBS. |
Biological Activity : | Human Kallikrein-1 active Unit Definitin: 1 unit will hydrolize 1 μmole of H-D-Val-Leu-Arg-pNA(S-2266) per minute at pH 8.0 at 37°C Human Kallikrein-1 measured biological activity of no less than 5 Units/mg (S2266 method). |
Stability : | KLK1 although stable at 4°C for 3 weeks, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles. |
Publication : |
Kallikrein–Kinin system suppresses Type i interferon responses: a novel Pathway of interferon regulation (2018)
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Gene Name : | KLK1 kallikrein 1 [ Homo sapiens ] |
Synonyms : | kallikrein serine protease 1; kallikrein 1, renal/pancreas/salivary; Klk6; KLKR; KLK1; hK1; kallikrein 1; tissue kallikrein; glandular kallikrein 1; EC 3.4.21.35; Kidney/pancreas/salivary gland kallikrein |
Gene ID : | 3816 |
mRNA Refseq : | NM_002257 |
Protein Refseq : | NP_002248 |
MIM : | 147910 |
UniProt ID : | P06870 |
Chromosome Location : | 19q13.3 |
Function : | peptidase activity; serine-type endopeptidase activity |
Products Types
◆ Recombinant Protein | ||
KLK1-089K | Active Recombinant Human KLK1 Protein (262 aa), C-6×His-tagged | +Inquiry |
KLK1-2944R | Recombinant Rat KLK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
KLK1-389C | Recombinant Cynomolgus Monkey KLK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
KLK1-0494H | Recombinant Human KLK1 Protein (I25-S262), Tag Free | +Inquiry |
Klk1-519M | Active Recombinant Mouse Klk1 protein(Met1-Asp261), His-tagged | +Inquiry |
◆ Native Protein | ||
KLK1-29685TH | Native Human KLK1 | +Inquiry |
◆ Lysates | ||
KLK1-2901HCL | Recombinant Human KLK1 cell lysate | +Inquiry |
KLK1-743MCL | Recombinant Mouse KLK1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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