lep
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  • Official Full Name
  • leptin
  • Background
  • This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
  • Synonyms
  • LEP; leptin; obesity factor; OB; obese; OBS
Cat.#:LEP-3626HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Leptin
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Cat.#:LEP-336HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Leptin
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Cat.#:LEP-225HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LEP
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Cat.#:LEP-260HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Leptin Antagonist Triple Mutant, PEG-tagged
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Cat.#:Lep-226MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Lep
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Cat.#:Lep-261MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Leptin Antagonist Triple Mutant
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Cat.#:Lep-228RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Lep
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Cat.#:Lep-338RTag:N/A
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit Leptin
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Cat.#:LEP-264OTag:N/A
Source (Host):E. coliSpecies:Ovine
Product nameRecombinant Ovine Leptin Antagonist Triple Mutant, PEG-tagged
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Cat.#:LEP-12HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Leptin, His Tag
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Cat.#:LEP-13HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Leptin, His-tagged
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Cat.#:LEP-189HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LEP protein
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Cat.#:LEP-202HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LEP, None tagged
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Cat.#:LEP-277HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human LEP, StrepII-tagged
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Cat.#:LEP-641HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LEP
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Cat.#:LEP-675HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LEP protein, His & GST-tagged
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Cat.#:Lep-16MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Leptin
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Cat.#:Lep-17MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Lep Protein, His/S-tagged
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Cat.#:Lep-18MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Leptin, Antagonist Triple Mutant
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Cat.#:Lep-6933MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Leptin
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Cat.#:LEP-9048MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LEP Protein
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Cat.#:Lep-147RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Leptin
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Cat.#:Lep-27RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Leptin, Antagonist Triple Mutant
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Cat.#:LEP-3376RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LEP Protein
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Cat.#:Lep-676RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Lep protein, His & T7-tagged
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Cat.#:LEP-2496RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey LEP Protein, His-tagged
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Cat.#:LEP-07CTag:N/A
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken Leptin
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Cat.#:LEP-08CTag:N/A
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken Leptin
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Cat.#:LEP-25RTag:N/A
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit Leptin
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Cat.#:LEP-674CTag:His/S
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken LEP protein, His & S-tagged
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Cat.#:LEP-19OTag:N/A
Source (Host):E. coliSpecies:Ovine
Product nameRecombinant Ovine Leptin
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Cat.#:LEP-20OTag:N/A
Source (Host):E. coliSpecies:Ovine
Product nameRecombinant Ovine Leptin, Antagonist Quadruple Mutant
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Cat.#:LEP-21OTag:N/A
Source (Host):E. coliSpecies:Ovine
Product nameRecombinant Ovine Leptin, Antagonist Triple Mutant
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Cat.#:LEP-22OTag:N/A
Source (Host):E. coliSpecies:Ovine
Product nameRecombinant Ovine Leptin, MTS-tagged
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Cat.#:LEP-23PTag:N/A
Source (Host):E. coliSpecies:Pufferfish
Product nameRecombinant Pufferfish Leptin
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Cat.#:LEP-24PTag:N/A
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Porcine Leptin
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Cat.#:Lep-337MTag:N/A
Source (Host):E. coliSpecies:Murine
Product nameRecombinant Murine Lep protein
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Cat.#:LEP-672CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle LEP protein, His & T7-tagged
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Cat.#:LEP-673HTag:His/T7
Source (Host):E. coliSpecies:Horse
Product nameRecombinant Horse LEP protein, His & T7-tagged
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Cat.#:LEP-81HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Leptin
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Cat.#:Lep-146MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Leptin, PEG
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Cat.#:Lep-28RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Leptin, Antagonist Triple Mutant, Mono-PEG
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Cat.#:LEP-09DTag:N/A
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog Leptin
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Cat.#:LEP-06BTag:N/A
Source (Host):E. coliSpecies:Bovine
Product nameRecombinant Bovine Leptin
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Cat.#:LEP-10HTag:N/A
Source (Host):E. coliSpecies:Equine
Product nameRecombinant Horse Leptin
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Cat.#:LEP-27641THTag:
Source (Host):E. coliSpecies:Human
Product nameNative Human LEP
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Cat.#:LEP-4773HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LEP 293 Cell Lysate
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Cat.#:LEP-164HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Leptin Reference standard
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Cat.#:Lep-166MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Leptin Reference standard
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Involved Pathway

LEP involved in several pathways and played different roles in them. We selected most pathways LEP participated on our site, such as Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEP were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
PRLRA; TNFRSF13C; ACVR1BA; IL18R1; IL21R.1; TNFRSF25; TNFSF13B; TNFRSF11B; ACVR2B; IL1R2
Neuroactive ligand-receptor interaction
UTS2R; F2R; GRIK3; HTR5A; CHRNA10; PRLHR; GABBR1; GABRR3A; PRLRA; ADORA2AB
AMPK signaling pathway
RAB11B; RAB8A; PCK1; STRADB; CPT1A; CPT1C; RAB10; PPP2R1B; MAP3K7; CAB39
Jak-STAT signaling pathway
IFNPHI3; IFNGR1; IFNK; FHL1A; CCND3; IL21; FHL1; PRP2; BCL2A; GRB2
Adipocytokine signaling pathway
SOCS3B; CD36; ACSL1; NFKBIA; RXRGB; JAK2B; G6PC3; LEPA; PRKAB1; PPARGC1A
Non-alcoholic fatty liver disease (NAFLD)
NDUFA9; PPARA; IL1A; NDUFS5; PRKAG2; NDUFB3; COX8C; UQCR11; NDUFV2; NDUFA12

Protein Function

LEP has several biochemical functions, for example, growth factor activity, hormone activity, peptide hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LEP itself. We selected most functions LEP had, and list some proteins which have the same functions with LEP. You can find most of the proteins on our site.
Function
Related Protein
Function growth factor activity
Related Protein BMP2; RABEP2; FBRS; HBEGFB; LEFTY2; FGF7; FGF12; BMP1; OGN; EFEMP1
Function hormone activity
Related Protein PRL7C1; ADCYAP1A; GCGA; TTR; TG; GH2; IGF2B; PRL5A1; Gh; GALP
Function peptide hormone receptor binding
Related Protein RUNDC3A; PTH; JAK2; PTHLHA; ADCYAP1; NPPC; PTPN11; NPPA; FYN; LEP