nefl
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  • Official Full Name
  • neurofilament, light polypeptide
  • Background
  • Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains.;Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role;in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations;in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous;system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.
  • Synonyms
  • NEFL; neurofilament, light polypeptide; neurofilament, light polypeptide 68kDa; neurofilament light polypeptide; CMT1F; CMT2E; NF68; NFL; neurofilament subunit NF-L; neurofilament triplet L protein; neurofilament protein, light chain; light molecular weig
Cat.#:NEFL-1472MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse NEFL Protein (2-543 aa), His-tagged
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Cat.#:NEFL-1292HTag:His-SUMO/MYC
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NEFL Protein, His-SUMO/MYC-tagged
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Cat.#:NEFL-1255HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NEFL, His-tagged
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Cat.#:NEFL-12HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NEFL, GST-tagged
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Cat.#:NEFL-13HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human NEFL protein, MYC/DDK-tagged
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Cat.#:NEFL-182HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant human NEFL
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Cat.#:NEFL-26033THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NEFL, His-tagged
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Cat.#:NEFL-10563MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NEFL Protein
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Cat.#:Nefl-10MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nefl protein, His-tagged
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Cat.#:NEFL-3952RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NEFL Protein
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Cat.#:NEFL-2996RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NEFL Protein, His-tagged
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Cat.#:NEFL-181BTag:
Source (Host):Species:Bovine
Product nameNative bovine NEFL
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Cat.#:NEFL-3884HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NEFL 293 Cell Lysate
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Involved Pathway

NEFL involved in several pathways and played different roles in them. We selected most pathways NEFL participated on our site, such as Amyotrophic lateral sclerosis (ALS), which may be useful for your reference. Also, other proteins which involved in the same pathway with NEFL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Amyotrophic lateral sclerosis (ALS)
BCL2L1; CAT; GRIN2A; DAXX; TRP53; GPX1; GRIA1; PPP3CA; CCS; GRIN2C

Protein Function

NEFL has several biochemical functions, for example, identical protein binding, phospholipase binding, protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEFL itself. We selected most functions NEFL had, and list some proteins which have the same functions with NEFL. You can find most of the proteins on our site.
Function
Related Protein
Function identical protein binding
Related Protein CDC42; HGF; TPCN1; RUNX1T1; WAS; ORAI1; CLDN2; GOT1; KHDC1A; TYROBP
Function phospholipase binding
Related Protein NEFL; WAS; PRKCZ; PDPK1; LMNB1; PTPN11; Pla2r1; ARHGAP6; CALM3; SERPINB1A
Function protein C-terminus binding
Related Protein TAE1; PEX26; JAK2; CSK; ABL1; VGLL3; CTBP1; SP1; TOP2A; ERCC2
Function protein binding
Related Protein ANLN; BCKDK; MMP20; AMPH; CAB39; GNG4; WAC; CLPX; WIBG; ABHD1
Function protein binding, bridging
Related Protein STX1A; FGA; RBM14; NEFH; TRIM5; TIRAP; LOR; CBX5; FRMD4A; MEN1
Function protein domain specific binding
Related Protein TJP1; VAPA; HOMER3; DIXDC1; NLRP1; HPCAL4; HIST1H4F; PLG; HIST1H4E; PLAUR
Function protein heterodimerization activity
Related Protein MAFG; NEFL; H2AFB3; PPARD; HIST1H2B8; MLXIPL; H2BFWT; JDP2; TYRO3; GTF2A2
Function structural constituent of cytoskeleton
Related Protein F-KER; EPB41; ADD3; TUBA8L2; TUBA3E; KRT2; TUBB4B; ARPC5; TUBA2; COX4I2

Interacting Protein

NEFL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEFL here. Most of them are supplied by our site. Hope this information will be useful for your research of NEFL.
APP; PPP1R18; TERF1; MTMR2; tax; TNF; YWHAG; SCHIP1; PHLPP1; VIM; RAN; CHD3