notch1
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  • Official Full Name
  • notch 1
  • Background
  • This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008]
  • Synonyms
  • NOTCH1; notch 1; hN1; TAN1; neurogenic locus notch homolog protein 1; Notch homolog 1, translocation-associated; translocation-associated notch protein TAN-1
Cat.#:NOTCH1-461HTag:HIgG1 Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human NOTCH1 Protein (Ala19-Gln526), HIgG1 Fc-tagged
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Cat.#:NOTCH1-5996HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NOTCH1 Protein, GST-tagged
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Cat.#:NOTCH1-29727THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NOTCH1
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Cat.#:NOTCH1-384HTag:Fc
Source (Host):NS0Species:Human
Product nameRecombinant Human NOTCH1 protein, Fc-tagged
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Cat.#:Notch1-400MTag:Fc Chimera
Source (Host):CHO cellsSpecies:Mouse
Product nameRecombinant Mouse Notch1, Fc Chimera
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Cat.#:Notch1-422MTag:His
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Notch1 protein, His-tagged
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Cat.#:Notch1-423MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Notch1 protein, Fc-tagged
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Cat.#:Notch1-435MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Notch1, Fc-tagged
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Cat.#:NOTCH1-884MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse NOTCH1 Protein, His-tagged
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Cat.#:NOTCH1-2220CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NOTCH1
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Cat.#:Notch1-2540RTag:Fc
Source (Host):NS0Species:Rat
Product nameRecombinant Rat Notch1, Fc Chimera
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Cat.#:NOTCH1-469MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse NOTCH1 cell lysate
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Involved Pathway

Notch1 involved in several pathways and played different roles in them. We selected most pathways Notch1 participated on our site, such as Dorso-ventral axis formation, Notch signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Notch1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Dorso-ventral axis formation
NOTCH1A; GRB2A; PPP1R2P9; SPIRE1; NOTCH3; PIWIL2; ETV6; MAPK3; NOTCH1; CPEB1B
Notch signaling pathway
PTCRA; ADAM12; DLL1; ADAM17; CNTN6; CTBP2; NUMBL; MYCBP; HER9; MARK2
Thyroid hormone signaling pathway
BMP4; MED27; MED30; ACTB; PIK3R5; ATP1B2; DIO2; PIK3R1; PRKACG; MAPK3
Prion diseases
MAP2K1; PRNP; C7; PRKACB; FYN; C5; PRKACA; IL1A; STIP1; C1QC
MicroRNAs in cancer
NOTCH3; TTC6; HNRNPK; IRS1; TRP53; TNN; ABCB1; PTEN; PDGFB; ABCB1A

Protein Function

Notch1 has several biochemical functions, for example, Notch binding, calcium ion binding, chromatin DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Notch1 itself. We selected most functions Notch1 had, and list some proteins which have the same functions with Notch1. You can find most of the proteins on our site.
Function
Related Protein
Function Notch binding
Related Protein JAG1A; NCOR2; EGFL7; DLL3; NOV; AAK1; JAG2; JAG1; ADAM17; JAG2B
Function calcium ion binding
Related Protein PLA2G1B; EPDL1; DGKA; PCDH2G4; ACTN3A; PCDH2G2; PCDH1G18; MMP3; RHOT1A; CABP1
Function chromatin DNA binding
Related Protein NEUROG3; GRHL1; AASS; VAX2; RELA; HIST1H1E; PRDM14; INSM1A; H2AFY2; GRHL3
Function core promoter binding
Related Protein CALCOCO1; NPAS2; NONO; RB1; PYDC3; MYBBP1A; MYOG; PSPC1; HDAC2; SPI1
Function enzyme binding
Related Protein ANK1; HDAC6; HSPA1A; ZNHIT6; BTG1; APP; NKX2-1; PLAUR; MAP2K7; CSF3
Function enzyme inhibitor activity
Related Protein FRY; NOTCH1; OAZ2B; UGT1A9; PRPSAP1; ANGPTL3; KIAA1967; ARRB1; GCHFR; ANGPTL4
Function protein binding
Related Protein ITM2A; BHLHE40; ATP6V1D; POLR2E; KIAA1737; TRIM33; MSX2; ZNF664-FAM101A; DDX21; CYB5R2
Function protein heterodimerization activity
Related Protein HIST1H4G; F11R.1; Pdgfa&Pdgfb; PEF1; TCF12; ADORA1; HGF; NFKB1; SNX6; GCLC
Function receptor activity
Related Protein GRIN2A; CD226; TNFRSF13B; PVRL3; TEK; OPN1SW; NLGN2; FKBP3; NRP2; ATRN
Function sequence-specific DNA binding
Related Protein EVX1; DMBX1; NR4A2A; SPIB; PAX3; HOXB13A; BCL11B; PNX; ZBTB4; HOXC5
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZHX2; ETV1; ZNF821; ZBTB48; GABPB1; E2F4; PITX2; TEAD1; ZNF445; TLX2
Function transcriptional activator activity, RNA polymerase II transcription factor binding
Related Protein NOTCH1; PPARA; WWP2; NKX2-5; NFE2L1; JUN; NKX2; SOX10; MIXL1; KLF4

Interacting Protein

Notch1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Notch1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Notch1.
RBPJ; XIAP; PIN1; SNW1

Notch1 Related Articles

Irshad, K; Mohapatra, SK; et al. A Combined Gene Signature of Hypoxia and Notch Pathway in Human Glioblastoma and Its Prognostic Relevance. PLOS ONE 10:-(2015).
Huntzicker, EG; Hotzel, K; et al. Differential Effects of Targeting Notch Receptors in a Mouse Model of Liver Cancer. HEPATOLOGY 61:942-952(2015).