Recombinant Human NOTCH1 protein, His-Avi-tagged, Biotinylated

• Cat.No.: NOTCH1-531HB
• Product Overview: Biotinylated Recombinant Human Notch 1 Protein is expressed from mammalian with His Tag and Avi Tag at the C-terminal. It contains Ala19-Gln526.

Specification

• Description: Human Notch-1 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes.Notch-1 functions as a receptor for membranebound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.
• Source: HEK293
• Species: Human
• Tag: His-Avi
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 56.5 KDa. Due to glycosylation, the protein migrates to 70-80KDa based on Bis-Tris PAGE result.
• Protein length: Ala19-Gln526
• Endotoxin: Less than 0.05EU per ug by the LAL method.
• Purity: > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: NOTCH1
• Official Symbol: NOTCH1
• Synonyms: EC 2.1.2.11; EC 3.4.21.68; hN1; Notch (Drosophila) homolog 1 (translocation-associated); notch 1Notch homolog 1, translocation-associated (Drosophila); Notch homolog 1, translocation-associated; Notch1; Notch-1; TAN1; TAN1neurogenic locus notch homolog protein 1; Translocation-associated notch protein TAN-1
• Gene ID: 4851
• mRNA Refseq: NM_017617.5
• Protein Refseq: NP_060087.3
• MIM: 190198
• UniProt ID: P46531