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Active Recombinant Human NOTCH1 protein, Fc-tagged

Cat.No. : NOTCH1-384H
Product Overview : Recombinant Human NOTCH1(Ala19 - Gln526) fused with Fc of Human IgG1 at C-terminal was expressed in NS0.
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Source : Mammalian cells
Species : Human
Tag : Fc
Predicted N Terminal : Ala19
Form : Lyophilized from a 0.2 μm filtered solution in PBS.
Bio-activity : Measured by its binding ability in a functional ELISA. Immobilized rhNotch-1 Fc Chimera at 5 µg/mL (100 µL/well) can bind rrJagged-1/Fc Chimera with an apparent KD <5 nM in a functional ELISA.
Molecular Mass : Predicted Molecular Mass: 80.1 (monomer) kDa;SDS-PAGE: 115-125 kDa, reducing conditions.
Endotoxin : <1.0 EU per 1 μg of the protein by the LAL method.
Purity : >90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Storage : Avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 centigrade as supplied.1 month, 2 to 8 centigrade under sterile conditions after reconstitution.3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : Reconstitute at 100 μg/mL in sterile PBS.
Protein length : Ala19-Gln526
Gene Name : NOTCH1 notch 1 [ Homo sapiens ]
Official Symbol : NOTCH1
Synonyms : NOTCH1; notch 1; Notch (Drosophila) homolog 1 (translocation associated) , Notch homolog 1, translocation associated (Drosophila) , TAN1; neurogenic locus notch homolog protein 1; Notch homolog 1, translocation-associated; translocation-associated notch protein TAN-1; hN1; TAN1;
Gene ID : 4851
mRNA Refseq : NM_017617
Protein Refseq : NP_060087
MIM : 190198
UniProt ID : P46531
Chromosome Location : 9q34.3
Pathway : Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Dorso-ventral axis formation, organism-specific biosystem; Dorso-ventral axis formation, conserved biosystem
Function : calcium ion binding; chromatin DNA binding; core promoter binding; protein binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;

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Customer Reviews (3)

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Reviews
01/24/2021

    Continuous access to up-to-date training materials ensured that our team remained well-versed in the product's capabilities.

    05/09/2017

      The product's evolution in response to user feedback showcased a dedication to meeting the evolving needs of researchers.

      11/04/2016

        The product's compatibility with open science practices positively influenced our decision to adopt it for our experiments.

        Q&As (7)

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        How does NOTCH1 contribute to the regulation of embryonic development and tissue homeostasis? 09/22/2022

        NOTCH1 contributes to the regulation of embryonic development and tissue homeostasis by influencing cell differentiation and proliferation.

        What are the ligands or interacting partners of NOTCH1, and how do they regulate its activation? 09/22/2021

        The ligands or interacting partners of NOTCH1 include Delta-like 1 (DLL1), Delta-like 3 (DLL3), Delta-like 4 (DLL4), Jagged 1, and Jagged 2, regulating its activation.

        What is the primary function of Neurogenic locus notch homolog protein 1 (NOTCH1) in cellular processes and signaling? 06/02/2021

        Neurogenic locus notch homolog protein 1 (NOTCH1) functions in cellular processes, primarily playing a role in the Notch signaling pathway.

        What diseases or conditions are associated with dysregulation or abnormal expression of NOTCH1? 05/12/2021

        Dysregulation or abnormal expression of NOTCH1 is associated with conditions such as cancer, cardiovascular diseases, and developmental disorders.

        In which cellular compartments is NOTCH1 predominantly localized? 02/24/2018

        NOTCH1 is predominantly localized on the cell membrane, where it undergoes proteolytic cleavage upon activation.

        Are there therapeutic implications or potential targets related to NOTCH1 in diseases involving Notch signaling? 07/09/2017

        There are potential therapeutic implications related to NOTCH1 in diseases involving Notch signaling, making it a target for drug development.

        How does NOTCH1 participate in the Notch signaling pathway, and what is its role in cell fate determination? 09/12/2016

        NOTCH1 participates in the Notch signaling pathway by interacting with ligands such as Delta and Jagged, influencing cell fate determination.

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