Active Recombinant Human NOTCH1 protein, Fc-tagged
Cat.No. : | NOTCH1-384H |
Product Overview : | Recombinant Human NOTCH1(Ala19 - Gln526) fused with Fc of Human IgG1 at C-terminal was expressed in NS0. |
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Source : | Mammalian cells |
Species : | Human |
Tag : | Fc |
Predicted N Terminal : | Ala19 |
Form : | Lyophilized from a 0.2 μm filtered solution in PBS. |
Bio-activity : | Measured by its binding ability in a functional ELISA. Immobilized rhNotch-1 Fc Chimera at 5 µg/mL (100 µL/well) can bind rrJagged-1/Fc Chimera with an apparent KD <5 nM in a functional ELISA. |
Molecular Mass : | Predicted Molecular Mass: 80.1 (monomer) kDa;SDS-PAGE: 115-125 kDa, reducing conditions. |
Endotoxin : | <1.0 EU per 1 μg of the protein by the LAL method. |
Purity : | >90%, by SDS-PAGE under reducing conditions and visualized by silver stain |
Storage : | Avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 centigrade as supplied.1 month, 2 to 8 centigrade under sterile conditions after reconstitution.3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | Reconstitute at 100 μg/mL in sterile PBS. |
Protein length : | Ala19-Gln526 |
Gene Name : | NOTCH1 notch 1 [ Homo sapiens ] |
Official Symbol : | NOTCH1 |
Synonyms : | NOTCH1; notch 1; Notch (Drosophila) homolog 1 (translocation associated) , Notch homolog 1, translocation associated (Drosophila) , TAN1; neurogenic locus notch homolog protein 1; Notch homolog 1, translocation-associated; translocation-associated notch protein TAN-1; hN1; TAN1; |
Gene ID : | 4851 |
mRNA Refseq : | NM_017617 |
Protein Refseq : | NP_060087 |
MIM : | 190198 |
UniProt ID : | P46531 |
Chromosome Location : | 9q34.3 |
Pathway : | Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Dorso-ventral axis formation, organism-specific biosystem; Dorso-ventral axis formation, conserved biosystem |
Function : | calcium ion binding; chromatin DNA binding; core promoter binding; protein binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; |
Products Types
◆ Recombinant Protein | ||
NOTCH1-5996H | Recombinant Human NOTCH1 Protein, GST-tagged | +Inquiry |
NOTCH1-2498H | Recombinant Human NOTCH1 Protein, His-tagged | +Inquiry |
NOTCH1-461H | Recombinant Human NOTCH1 Protein (Ala19-Gln526), HIgG1 Fc-tagged | +Inquiry |
NOTCH1-531H | Recombinant Human NOTCH1 protein, His-Avi-tagged | +Inquiry |
NOTCH1-127H | Recombinant Human NOTCH1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
NOTCH1-469MCL | Recombinant Mouse NOTCH1 cell lysate | +Inquiry |
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Customer Reviews (3)
Write a reviewContinuous access to up-to-date training materials ensured that our team remained well-versed in the product's capabilities.
The product's evolution in response to user feedback showcased a dedication to meeting the evolving needs of researchers.
The product's compatibility with open science practices positively influenced our decision to adopt it for our experiments.
Q&As (7)
Ask a questionNOTCH1 contributes to the regulation of embryonic development and tissue homeostasis by influencing cell differentiation and proliferation.
The ligands or interacting partners of NOTCH1 include Delta-like 1 (DLL1), Delta-like 3 (DLL3), Delta-like 4 (DLL4), Jagged 1, and Jagged 2, regulating its activation.
Neurogenic locus notch homolog protein 1 (NOTCH1) functions in cellular processes, primarily playing a role in the Notch signaling pathway.
Dysregulation or abnormal expression of NOTCH1 is associated with conditions such as cancer, cardiovascular diseases, and developmental disorders.
NOTCH1 is predominantly localized on the cell membrane, where it undergoes proteolytic cleavage upon activation.
There are potential therapeutic implications related to NOTCH1 in diseases involving Notch signaling, making it a target for drug development.
NOTCH1 participates in the Notch signaling pathway by interacting with ligands such as Delta and Jagged, influencing cell fate determination.
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