nppb
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  • Official Full Name
  • natriuretic peptide B
  • Background
  • This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.
  • Synonyms
  • NPPB; natriuretic peptide B; BNP; natriuretic peptides B; OTTHUMP00000002506; natriuretic protein; brain type natriuretic peptide; gamma-brain natriuretic peptide; natriuretic peptide precursor B; Brain natriuretic peptide; B-type natriuretic peptide
Cat.#:NPPB-1298HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NPPB Protein, GST-tagged
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Cat.#:NPPB-1409HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NPPB Protein, His-tagged
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Cat.#:NPPB-6042HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NPPB Protein, GST-tagged
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Cat.#:NPPB-2682HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Natriuretic Peptides B, aa 1-76
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Cat.#:NPPB-2683HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Natriuretic Peptides B, aa 1-108
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Cat.#:NPPB-1857HTag:
Source (Host):Species:Human
Product nameSynthesized Human B-type Natriuretic Peptide
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Cat.#:NPPB-20HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Natriuretic Peptide Precursor B
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Cat.#:NPPB-26901THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NPPB, His-tagged
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Cat.#:NPPB-31085THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NPPB
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Cat.#:NPPB-369HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Brain Natriuretic Peptide (type B natriuretic peptide), His-tagged
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Cat.#:NPPB-53HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NPPB protein, His-tagged
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Cat.#:NPPB-893HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NPPB protein, His & GST-tagged
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Cat.#:NPPB-10831MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NPPB Protein
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Cat.#:Nppb-2767MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nppb protein, His-tagged
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Cat.#:Nppb-2768MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nppb protein, His & GST-tagged
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Cat.#:NPPB-4047RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NPPB Protein
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Cat.#:NPPB-2766DTag:His/GST
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog NPPB protein, His & GST-tagged
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Cat.#:NPPB-6486CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NPPB
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Cat.#:NPPB-2769PTag:His/GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig NPPB protein, His & GST-tagged
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Cat.#:NPPB-8050HTag:N/A
Source (Host):Human brainSpecies:Human
Product nameNative Human Brain Natriuretic Peptide 32
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Cat.#:Nppb-5459RTag:N/A
Source (Host):RatSpecies:Rat
Product nameNative Rat Natriuretic Peptide B
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Cat.#:NPPB-8052RTag:N/A
Source (Host):RatSpecies:Rat
Product nameNative Rat Brain Natriuretic Peptide-32
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Cat.#:NPPB-3734HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NPPB 293 Cell Lysate
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Cat.#:NPPB-P029HTag:
Source (Host):N/ASpecies:Human
Product nameRecombinant Human NPPB therapeutic protein
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Involved Pathway

NPPB involved in several pathways and played different roles in them. We selected most pathways NPPB participated on our site, such as cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPPB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cGMP-PKG signaling pathway
AKT2; CALM2; ATP2A3; PDE3B; PPP1CA; PIK3R2; MEF2D; NPR1; KCNJ8; PIK3R5

Protein Function

NPPB has several biochemical functions, for example, diuretic hormone activity, hormone activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPPB itself. We selected most functions NPPB had, and list some proteins which have the same functions with NPPB. You can find most of the proteins on our site.
Function
Related Protein
Function diuretic hormone activity
Related Protein NPPB
Function hormone activity
Related Protein UCN3; PRL7B1; SST6; UTS2; GAST; BMP10; AGT; PPY; UTS1; GNRH3
Function protein binding
Related Protein HSPB9; CSRNP2; SLC2A4; POLR3GL; NFU1; SHMT2; ZNF187; RFPL4; CD274; PRSS8
Function receptor binding
Related Protein TNFSF9; ADAM10; GRP; PTK2AB; GAS6; PECR; CAPRIN2; HAMP; H2-Q10; CADM1B

Interacting Protein

NPPB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPPB here. Most of them are supplied by our site. Hope this information will be useful for your research of NPPB.
PSMA3; KRTAP10-9; KRT40; NOTCH2NL; DPP4; FAP; EWSR1

NPPB Related Articles

Goswami, SC; Thierry-Mieg, D; et al. Itch-associated peptides: RNA-Seq and bioinformatic analysis of natriuretic precursor peptide B and gastrin releasing peptide in dorsal root and trigeminal ganglia, and the spinal cord. MOLECULAR PAIN 10:-(2014).
Gallos, G; Remy, KE; et al. Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 305:L625-L634(2013).