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NPPB

  • Official Full Name

    natriuretic peptide B

  • Overview

    This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.
  • Synonyms

    NPPB; natriuretic peptide B; BNP; natriuretic peptides B; OTTHUMP00000002506; natriuretic protein; brain type natriuretic peptide; gamma-brain natriuretic peptide; natriuretic peptide precursor B; Brain natriuretic peptide; B-type natriuretic peptide;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Therapeutic Proteins
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Chicken
  • Dog
  • Human
  • Mouse
  • Pig
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Protein Conjugation
  • Rat
  • Wheat Germ
  • C
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
  • His Flag
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NPPB-53H Recombinant Human NPPB protein, His-tagged E.coli His
Human NPPB-1857H Synthesized Human B-type Natriuretic Peptide N/A
Human NPPB-369H Recombinant Human Brain Natriuretic Peptide (type B natriuretic peptide), His-tagged E.coli His
Human NPPB-2683H Recombinant Human Natriuretic Peptides B, aa 1-108 E.coli N/A
Human NPPB-2682H Recombinant Human Natriuretic Peptides B, aa 1-76 E.coli N/A
Human NPPB-20H Recombinant Human NPPB protein E.coli N/A 32
Human NPPB-31085TH Recombinant Human NPPB protein E.coli N/A 76
Human NPPB-26901TH Recombinant Human NPPB, His-tagged E.coli His
Human NPPB-893H Recombinant Human NPPB protein, His & GST-tagged E.coli His/GST
Human NPPB-1298H Recombinant Human NPPB Protein, GST-tagged E.coli GST
Human NPPB-3734HCL Recombinant Human NPPB 293 Cell Lysate HEK293 N/A
Human NPPB-6042H Recombinant Human NPPB Protein, GST-tagged Wheat Germ GST
Human NPPB-6643HF Recombinant Full Length Human NPPB Protein, GST-tagged In Vitro Cell Free System GST 134 amino acids
Human NPPB-8050H Synthetic Human Brain Natriuretic Peptide 32 Human
Human NPPB-4733H Recombinant Human NPPB Protein (His27-Arg102), N-His tagged E.coli N-His His27-Arg102
Human NPPB-1409H Recombinant Human NPPB Protein, His-tagged E. coli His
Human NPPB-P029H Recombinant Human NPPB therapeutic protein N/A 32aa
Human NPPB-4734H Recombinant Human NPPB Protein (Ser103-His134), C-Fc tagged Mammalian cells C-Fc Ser103-His134
Human NPPB-4732H Recombinant Human NPPB Protein (His27-Arg102), N-His Flag tagged E.coli N-His Flag His27-Arg102
Human NPPB-388H Recombinant Human NPPB Protein, His&SUMO-tagged E.coli N-His&SUMO Ser103-His134
Human NPPB-2826H Recombinant Human NPPB Protein, His-tagged, OVA Conjugated Protein Conjugation N-His Glu39-Lys53
Mouse Nppb-2768M Recombinant Mouse Nppb protein, His & GST-tagged E.coli His/GST Tyr27~Leu121 (Accession # P40753)
Mouse Nppb-2767M Recombinant Mouse Nppb protein, His-tagged E.coli His Tyr27~Leu121
Mouse NPPB-10831M Recombinant Mouse NPPB Protein Mammalian Cell His
Mouse Nppb-389M Recombinant Mouse Nppb Protein, His&SUMO-tagged E.coli N-His&SUMO Ser77-Leu121
Mouse NPPB-6170M Recombinant Mouse NPPB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Nppb-1852M Recombinant Mouse Nppb Protein, His&GST-tagged E.coli N-His&GST Tyr27-Arg76
Mouse NPPB-6170M-B Recombinant Mouse NPPB Protein Pre-coupled Magnetic Beads HEK293
Rat NPPB-4047R Recombinant Rat NPPB Protein Mammalian Cell His
Rat Nppb-1851R Recombinant Rat Nppb Protein, His-tagged E.coli N-His His27-Ser77
Rat Nppb-390R Recombinant Rat Nppb Protein, His&SUMO-tagged E.coli N-His&SUMO Ser77-Phe121
Rat NPPB-3706R Recombinant Rat NPPB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NPPB-8052R Native Rat Brain Natriuretic Peptide-32 Rat N/A
Rat NPPB-3706R-B Recombinant Rat NPPB Protein Pre-coupled Magnetic Beads HEK293
Rat Nppb-5459R Native Rat Natriuretic Peptide B Rat N/A
Dog NPPB-2766D Recombinant Dog NPPB protein, His & GST-tagged E.coli His/GST His18~Arg106 (Accession # P16859)
Pig NPPB-2769P Recombinant Pig NPPB protein, His & GST-tagged E.coli His/GST His26~Tyr131
Chicken NPPB-6486C Recombinant Chicken NPPB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NPPB Related Articles

NPPB involved in several pathways and played different roles in them. We selected most pathways NPPB participated on our site, such as cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPPB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cGMP-PKG signaling pathwayIRS2;AKT1;PLCB4;SLC25A4;INSR;ATP2A2;CALML5;BNP;IRS1

NPPB has several biochemical functions, for example, diuretic hormone activity, hormone activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPPB itself. We selected most functions NPPB had, and list some proteins which have the same functions with NPPB. You can find most of the proteins on our site.

Function Related Protein
diuretic hormone activity
hormone activityPTHLH;RETNLB;GPHB5;EPO;UTS2D;CHGB;STC2A;PRL3B1;TTR
protein bindingDNTTIP1;CCDC64;TPP1;RHOT2;SCIMP;MIA3;AGFG1;RAD50;E2F8
receptor bindingSSFA2;TENC1;FYNA;WNT11R;RARA;GSDMA2;BLK;HAO2;MAP7

NPPB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPPB here. Most of them are supplied by our site. Hope this information will be useful for your research of NPPB.

PSMA3; KRTAP10-9; KRT40; NOTCH2NL; DPP4; FAP; EWSR1

Goswami, SC; Thierry-Mieg, D; et al. Itch-associated peptides: RNA-Seq and bioinformatic analysis of natriuretic precursor peptide B and gastrin releasing peptide in dorsal root and trigeminal ganglia, and the spinal cord. MOLECULAR PAIN 10:-(2014).
Gallos, G; Remy, KE; et al. Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 305:L625-L634(2013).
  • Q&As
  • Reviews

Q&As (5)

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In what ways does NPPB protein contribute to the understanding of fluid overload in patients? 04/20/2022

Elevated NPPB levels are associated with fluid overload, providing valuable information for clinicians in managing patients with conditions like edema.

Can NPPB protein be used in monitoring the efficacy of treatments for cardiovascular diseases? 03/02/2020

Yes, monitoring NPPB levels over time can help assess the effectiveness of treatments and interventions in managing cardiovascular conditions.

How do age and gender influence the normal range of NPPB protein levels in healthy individuals? 04/25/2019

Normal ranges of NPPB may vary with age and gender. Understanding these variations is essential for accurate clinical interpretation.

Are there any specific contraindications or limitations in using NPPB protein as a clinical marker? 11/26/2016

While NPPB is a valuable marker, clinicians should consider factors like renal function and comorbidities that may affect its interpretation.

How does NPPB protein influence the management of hypertension in clinical practice? 06/11/2016

NPPB regulates blood pressure by promoting vasodilation and natriuresis. Understanding its levels can guide the management of hypertension.

Customer Reviews (3)

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Reviews
06/17/2022

    They actively engage with researchers, comprehending their specific experimental needs, and offering tailored services accordingly.

    01/16/2022

      This collaborative partnership facilitates a seamless and efficient research process, as the manufacturer aligns their support and services with my unique requirements.

      12/09/2019

        The manufacturer's excellent technical support, commitment to innovation, and customer-centric approach further reinforce its suitability for my research.

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