Notch1
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Official Full Name
notch 1 -
Overview
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008] -
Synonyms
NOTCH1;notch 1;hN1;TAN1;neurogenic locus notch homolog protein 1;Notch homolog 1, translocation-associated;translocation-associated notch protein TAN-1
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- HEK293
- Mammalian Cells
- CHO
- Insect Cells
- Wheat Germ
- E.coli
- His
- Fc
- Non
- Avi
- GST
- Myc
Involved Pathway
Notch1 involved in several pathways and played different roles in them. We selected most pathways Notch1 participated on our site, such as Dorso-ventral axis formation,Notch signaling pathway,Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Notch1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MicroRNAs in cancer | ERBB3,WNT3A,MDM4,IRS1,ZFPM2,MARCKS,PDGFA,TPM1,CCND1,SHC1 |
| Prion diseases | C9,FYN,C6,STIP1,NCAM1,C5,NCAM2,IL1B,LOC100033925,C8G |
| Notch signaling pathway | DLA,APH1C,DTX1,NOTCH2,HER9,EP300,HER12,JAG1B,NOTCH4,PSEN2 |
| Thyroid hormone signaling pathway | ITGAV,HDAC1,ATP1B2,DIO3,FOXO1,RAF1,AKT2,PRKACA,RHEB,KAT2A |
| Dorso-ventral axis formation | SPIRE1A,PIWIL4,SPIRE1,ETS2,PIWIL2,MAPK1,NOTCH1A,ETS1,CPEB3,SPIRE2 |
Protein Function
Notch1 has several biochemical functions, for example, Notch binding,calcium ion binding,chromatin DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Notch1 itself. We selected most functions Notch1 had, and list some proteins which have the same functions with Notch1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| core promoter binding | INSM1B,CCAR1,KLF4,XBP1,FOXP3,DHX36,NPAS2,SFPI1,IRF9,NKX3-1 |
| receptor activity | ITGB3A,TNFRSF11A,TNFRSF17,GRIA4A,GRIA4B,THRAP3,KLRG1,TEK,KIR2DL3,GRIN2BB |
| protein binding | NDP,VPREB1,SRSF2,UFD1L,RSL24D1,NPLOC4,DPH3,CCDC141,KRTAP3-1,RFX3 |
| enzyme binding | HMGA1,PCCA,Alb,IQCB1,BIRC5,TSPAN10,LDB2,HYAL2,ADORA2A,UGT1A1 |
| protein heterodimerization activity | TGFB2,HER11,DMRT3A,HIST3H2BB,NFKB1,HIST1H2BM,PANX1,CENPA,UGT1A3,HGF |
| Notch binding | JAG1,DNER,JAG1A,AAK1,EGFL7,CHAC1,ADAM17,DLL4,C8orf4,JAG2B |
| enzyme inhibitor activity | TAE1,ARRB1,UGT1A1,APBA3,ATPIF1B,PDE6G,OAZ2B,CSN2,PLN,ATPIF1A |
| calcium ion binding | SULF1,JAG1B,CDH10A,IHH,PCDH10A,EFHA1,DHH,PCDH2G9,CD248,GUCA1B |
| sequence-specific DNA binding | FLI1B,PRRX2,MXTX2,E2F5,HOXC9A,FOXD1,FOXA3,SOX6,POU3F3,TFAP2A |
Interacting Protein
Notch1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Notch1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Notch1.
RBPJ;XIAP;PIN1;SNW1
Notch1 Related Signal Pathway
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References
- Irshad, K; Mohapatra, SK; et al. A Combined Gene Signature of Hypoxia and Notch Pathway in Human Glioblastoma and Its Prognostic Relevance. PLOS ONE 10:-(2015).
- Huntzicker, EG; Hotzel, K; et al. Differential Effects of Targeting Notch Receptors in a Mouse Model of Liver Cancer. HEPATOLOGY 61:942-952(2015).
