Notch1 Protein, notch 1


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Official Full Name notch 1
Background This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008]
Synonyms NOTCH1; notch 1; hN1; TAN1; neurogenic locus notch homolog protein 1; Notch homolog 1, translocation-associated; translocation-associated notch protein TAN-1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • CHO
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • Fc
    • Fc Chimera
    • GST
    • HIgG1 Fc
    • His
    • His-Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NOTCH1-385H Recombinant Human NOTCH1 protein, His-tagged HEK293 His
    Human NOTCH1-461H Recombinant Human NOTCH1 Protein (Ala19-Gln526), HIgG1 Fc-tagged HEK293 HIgG1 Fc
    Human NOTCH1-531H Recombinant Human NOTCH1 protein, His-Avi-tagged HEK293 His-Avi
    Human NOTCH1-531HB Recombinant Human NOTCH1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human NOTCH1-29727TH Recombinant Human NOTCH1 Wheat Germ N/A
    Human NOTCH1-384H Recombinant Human NOTCH1 protein, Fc-tagged NS0 Fc
    Human NOTCH1-5996H Recombinant Human NOTCH1 Protein, GST-tagged Wheat Germ GST
    Mouse Notch1-400M Recombinant Mouse Notch1, Fc Chimera CHO Fc Chimera
    Mouse Notch1-422M Recombinant Mouse Notch1 protein, His-tagged Insect Cell His
    Mouse Notch1-423M Recombinant Mouse Notch1 protein, Fc-tagged CHO Fc
    Mouse Notch1-435M Recombinant Mouse Notch1, Fc-tagged CHO Fc
    Mouse NOTCH1-469MCL Recombinant Mouse NOTCH1 cell lysate Insect Cell N/A
    Mouse NOTCH1-884M Recombinant Mouse NOTCH1 Protein, His-tagged Insect Cell His
    Rat Notch1-2540R Recombinant Rat Notch1, Fc Chimera NS0 Fc
    Chicken NOTCH1-2220C Recombinant Chicken NOTCH1 Mammalian Cell His

    Notch1 involved in several pathways and played different roles in them. We selected most pathways Notch1 participated on our site, such as Dorso-ventral axis formation, Notch signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Notch1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Dorso-ventral axis formation PPP1R2P9; CPEB2; NOTCH1; PIWIL1; CPEB1B; EGFRA; ETV7; MAP2K1; KRAS; NOTCH2
    Notch signaling pathway DLC; HER15.1; MIB1; DVL1B; PSENEN; APH1B; NOTCH1B; CTBP2A; ADAM17; APH1C
    Thyroid hormone signaling pathway ATP1A2; NCOA1; MED27; RXRB; PRKACB; RCAN2; MED30; MAPK3; CASP9; MAP2K1
    Prion diseases MAPK3; ELK1; HSPA5; PRKACG; NOTCH1; C1QC; NCAM2; STIP1; LOC100033925; C8B
    MicroRNAs in cancer TPM1; HMGA2; VEGFA; EP300; RPS6KA5; CCND1; MAPK7; GLS2; DNMT3A; ZFPM2

    Notch1 has several biochemical functions, for example, Notch binding, calcium ion binding, chromatin DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Notch1 itself. We selected most functions Notch1 had, and list some proteins which have the same functions with Notch1. You can find most of the proteins on our site.

    Function Related Protein
    Notch binding CHAC1; JAG1B; HIF1AN; EGFL7; DLL4; DLL1; NOTCH4; AAK1; NOTCH1; DNER
    calcium ion binding OTOF; BMP1B; FAT3A; LPCAT1; PROC; FAT1A; PCDH2G29; PCDH2AB3; PNLIPRP1; PEF1
    chromatin DNA binding HIST1H1C; THRA; PPARGC1A; HIST1H1E; SMAD3; NOTCH1; GRHL3; APEX1; GRHL1; RARA
    core promoter binding KDM3A; GADD45A; GTF2B; ARNTL; HNRNPU; CLOCK; RB1; MYBBP1A; ELK4; NKX2-1
    enzyme binding PHB; SORT1; ATF7; ARPC4; CALU; CBX3; HIST1H2AG; HAND2; TP53; LAMB1
    enzyme inhibitor activity CD46; PPP1R12A; PDE6H; APBA3; GCHFR; TAE1; DGKZ; CALU; ANGPTL3; CSN2
    protein binding TRAPPC3; NDFIP2; BLOC1S2; HS3ST5; ANKHD1; XRN1; LCAT; GIMAP7; SHISA3; HSBP1
    protein heterodimerization activity UGT1A6; BCL2A1; HIST1H4F; TAL1; ROPN1B; EXT1; TRP53; OSTB; CD3G; H2AFY2
    receptor activity CSF3R; P2RY11; KLRB1F; JMJD6; ITGB1B.1; ANPEP; NLGN4Y; GRIA4A; ANTXR2A; SMAGP
    sequence-specific DNA binding ISL1L; IKZF3; GATA1A; FOXB1B; HHEX; FOXH1; HOXC1A; EMX3; MAEL; HOXC11A
    transcription factor activity, sequence-specific DNA binding SALL4; FOXE3; TTC4; TBX2A; RXRA; HOXB6B; TBX24; MAFG; RXRAA; ATF6
    transcriptional activator activity, RNA polymerase II transcription factor binding GBX2; LMO2; NKX2; MED12; PITX1; SOX10; CREB1; NFE2L1; KLF4; KLF14

    Notch1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Notch1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Notch1.


    Irshad, K; Mohapatra, SK; et al. A Combined Gene Signature of Hypoxia and Notch Pathway in Human Glioblastoma and Its Prognostic Relevance. PLOS ONE 10:-(2015).
    Huntzicker, EG; Hotzel, K; et al. Differential Effects of Targeting Notch Receptors in a Mouse Model of Liver Cancer. HEPATOLOGY 61:942-952(2015).

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