rock2
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  • Official Full Name
  • Rho-associated, coiled-coil containing protein kinase 2
  • Background
  • The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ROCK2; Rho-associated, coiled-coil containing protein kinase 2; ROCK-II; rho-associated protein kinase 2; p164 ROCK-2; rho-associated, coiled-coil-containing protein kinase II;
Cat.#:ROCK2-1879HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ROCK2 Protein, His-tagged
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Cat.#:ROCK2-1878HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ROCK2 protein, His & T7-tagged
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Cat.#:ROCK2-26HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ROCK2 protein, GST-tagged
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Cat.#:ROCK2-30955THTag:
Source (Host):Species:Human
Product nameRecombinant Human ROCK2
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Cat.#:ROCK2-421HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ROCK2, GST-tagged, Active
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Cat.#:ROCK2-672HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ROCK2 protein, MYC/DDK-tagged
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Cat.#:ROCK2-712HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ROCK2, GST-His
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Cat.#:ROCK2-3952RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ROCK2 Protein, His-tagged
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Cat.#:ROCK2-2255HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ROCK2 293 Cell Lysate
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Involved Pathway

ROCK2 involved in several pathways and played different roles in them. We selected most pathways ROCK2 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ROCK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cGMP-PKG signaling pathway
INS1; CALM4; ATP1A1; NPR2; CALM3; CREB5; MYLK; PRKG1; PPP3CB; GNAI3
cAMP signaling pathway
RAP1A; ORAI1; NFKB1; GLP1R; LOC100328615; GRIN2B; GIPR; GRIA4; NFATC1; VAV3
Chemokine signaling pathway
CCL3; PAK1; PLCB4; PF4V1; PIK3CA; GM10591; NRAS; PF4; LYN; CCL19
Sphingolipid signaling pathway
SPTLC3; PPP2R3C; GNAI2; PRKCZ; SPHK1; TNF; ACER1; PIK3CB; CERS2; GAB2
Vascular smooth muscle contraction
RHOAD; PRKCBA; CACNA1SB; ADCY2B; MYL6B; CYP4A14; KCNMB4; PLA2G4AA; CALM1B; PLCB4
Wnt signaling pathway
CUL1A; BAMBIA; SMAD3; CUL1; WIF1; WNT2B; GSK3AA; TCF7; FBXW2; WNT3A
Axon guidance
PAK2; RHOC; KCNQ2; ITGB1B.1; EPHA2A; SPTA1; SEMA4B; EPHA3; ARPC1B; WDR83
Focal adhesion
PPP1CAA; CAV2; PDGFAA; MAPK6; PPP1R12B; VEGFA; RAF1B; BRAF; RHOAD; BIRC3
Platelet activation
FERMT3; STIM1; PRKCZ; AKT1; PLCB3; PLCB4; ITGB1; ACTG1; PRKACB; ARHGEF1
Leukocyte transendothelial migration
NCF1; ITGB2L; ROCK1; F11R; MYL2; CD99; MYLPF; PIK3R1; ARHGAP35; CLDN3
Regulation of actin cytoskeleton
BDKRB2; FGF5; PDGFB; ARHGEF1; PXN; PIP5K1AB; PPP1CC; PIK3R3; PIK3R2; SOS1
Oxytocin signaling pathway
CAMK2D; CAMK1G; RYR2; PIK3R3; PRKACB; PPP3CC; RAF1; PPP3CA; MYLK3; MAPK7
Pathogenic Escherichia coli infection
YWHAZ; FYN; WASL; TUBA1A; TUBA3C; ABL1; TUBA3D; TUBB1; LY96; TUBB
Shigellosis
RIPK2; ROCK2; MAPK11; RHOG; IKBKG; ACTG1; MAPK8; ITGA5; PFN3; MAPK12
Salmonella infection
CCL3L3; RELA; WASLA; IL-8; DYNC1LI2; RHOGD; MYH10; IFNG1-2; TLR4; IL1B
Pathways in cancer
RAC3; PLCG1; RAD51; WNT16; CCDC6; NFKB2; CBLB; FGF22; SMO; MAX
Proteoglycans in cancer
CD44; WNT9A; MMP9; PPP1R12C; FAS; PAK1; RPS6KB2; ACTG1; GPC1; WNT10B

Protein Function

ROCK2 has several biochemical functions, for example, ATP binding, Rho GTPase binding, Rho-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ROCK2 itself. We selected most functions ROCK2 had, and list some proteins which have the same functions with ROCK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ABCA1B; MTHFD1B; DNAJA4; MAP3K15; MAPK8; PKN3; MYO1EB; MATK; MKNK1; Atp8a2
Function Rho GTPase binding
Related Protein ARHGEF2; DOCK9; INF2; PFN1; PARD6A; ROCK2B; LRRK2; ROCK2A; KIF3B; DAAM1B
Function Rho-dependent protein serine/threonine kinase activity
Related Protein ROCK2
Function metal ion binding
Related Protein ZSWIM4; CSRP1B; KDM2AA; AMY1B; TRIM35-35; ATP1A2A; GALNTL2; CDKAL1; CYP2N13; GART
Function poly(A) RNA binding
Related Protein CKAP4; ZCCHC9; HIST1H4I; UTP11L; EIF4ENIF1; GLRX3; C1orf35; EZR; DQX1; GLTSCR2
Function protein binding
Related Protein RNF149; PLAC9; POLR1B; MARK2; RNPS1; C2orf63; CHAMP1; TDGF1; IFT20; KBTBD6
Function protein serine/threonine kinase activity
Related Protein MAPK14A; ACVR2B; PAK2A; PHKG2; CLK4; PRKG1A; TSSK1; VRK3; MAP4K1; PRKD1
Function structural molecule activity
Related Protein VCL; SPRR2H; SPRR2A; EVPL; KRT71; KRT35; SNTA1; EPB41L3B; LCE4A; CLDN11

Interacting Protein

ROCK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ROCK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ROCK2.
NFKBIA; PPP1R14B; 15777285; STK16; NCL; IKBKE; purvalanol b; STAU1; Rock1; SNW1; FLOT2; N; CDC5L

ROCK2 Related Articles

Gerarduzzi, C; He, QW; et al. Prostaglandin E-2-Dependent Blockade of Actomyosin and Stress Fibre Formation Is Mediated Through S1379 Phosphorylation of ROCK2. JOURNAL OF CELLULAR BIOCHEMISTRY 115:1516-1527(2014).
Huang, P; Wang, J; et al. The effects of erythropoietin on RhoA/Rho-associated kinase expression in rat retinal explants cultured with glutamate. MOLECULAR MEDICINE REPORTS 6:662-666(2012).