rock2
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  • Official Full Name
  • Rho-associated, coiled-coil containing protein kinase 2
  • Background
  • The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ROCK2; Rho-associated, coiled-coil containing protein kinase 2; ROCK-II; rho-associated protein kinase 2; p164 ROCK-2; rho-associated, coiled-coil-containing protein kinase II;
Cat.#:ROCK2-1878HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ROCK2 protein, His & T7-tagged
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Cat.#:ROCK2-26HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ROCK2 protein, GST-tagged
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Cat.#:ROCK2-30955THTag:
Source (Host):Species:Human
Product nameRecombinant Human ROCK2
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Cat.#:ROCK2-421HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ROCK2, GST-tagged, Active
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Cat.#:ROCK2-672HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ROCK2 protein, MYC/DDK-tagged
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Cat.#:ROCK2-712HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ROCK2, GST-His
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Cat.#:ROCK2-3952RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ROCK2 Protein, His-tagged
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Cat.#:ROCK2-2255HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ROCK2 293 Cell Lysate
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Involved Pathway

ROCK2 involved in several pathways and played different roles in them. We selected most pathways ROCK2 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ROCK2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cGMP-PKG signaling pathway
RGS2; PPP1CB; PIK3CB; IRS4; NPR1; GNA11; NFATC3; AKT2; GATA4; CALML5
cAMP signaling pathway
GLI1; NFATC1; CAMK4; MLLT4; RHOA; ORAI1; RAF1; RAC3; MAPK3; SLC9A1
Chemokine signaling pathway
GM2506; CCL23; PRKACB; GM13304; CXCL1; CXCL11; XCR1; CCL26; PPBP; STAT3
Sphingolipid signaling pathway
PPP2R1B; ROCK2; SPTLC3; RHOA; ASAH2; SGMS2; RAC3; BAX; BID; GAB2
Vascular smooth muscle contraction
CALM1; MYL9B; PLA2G12A; PRKCH; CACNA1D; PRKCBA; MLCK2; PLA2G2D; CALM2; CYP4A10
Wnt signaling pathway
PRKCA; FZD3; WNT7AA; FZD9; WNT1; TRP53; PPP3R1B; MAPK9; SMAD4; TP53
Axon guidance
CNTN6; NEFLB; CLTA; EPHB4B; DUSP7; NRTN; PAK7; CREB1B; SHB; RHOGA
Focal adhesion
SHC4; PDGFA; MAPK6; PIK3R3; PDGFAB; COL11A1A; COL24A1; LAMA5; COL2A1A; LAMB1A
Platelet activation
P2RX1; PLA2G4A; PLA2G4C; MAPK11; FGB; AKT2; PLCB4; RAP1A; GP1BA; ARHGAP35
Leukocyte transendothelial migration
PIK3R2; MYL7; VAV1; NCF1; CLDN11; PXN; GNAI2; OCLN; CLDN7; Itgam&Itgb2
Regulation of actin cytoskeleton
ACTG1; FN1A; RDX; GSNB; FGF18A; VCLA; CFL2; PIP5K1BB; PDGFA; FGF1
Oxytocin signaling pathway
PPP1CA; PRKCA; CAMK1D; GUCY1A3; PIK3CA; CACNA2D4; NFATC4; PPP3CA; CALM4; CALML3
Pathogenic Escherichia coli infection
ABL1; TLR5; TUBB1; CD14; KRT18; YWHAZ; ARHGEF2; CDH1; TUBAL3; CDC42
Shigellosis
RAC1; RELA; PFN4; ELMO1; U2AF1L4; ACTG1; CD44; WAS; IKBKB; PFN1
Salmonella infection
NLRC4; RHOGD; MAPK11; ACTB; MAPK9; RELA; PFN2L; NOS2; IFNG1-2; ROCK2B
Pathways in cancer
AHA-1; APC2; MSH2; STK4; TP53; Fzd4; GNG13; RASSF1; SMAD4; TRAF2
Proteoglycans in cancer
FZD10; PIK3R2; HCLS1; RAF1; PXN; MRAS; IL12B; PAK1; Casp3; WNT3A

Protein Function

ROCK2 has several biochemical functions, for example, ATP binding, Rho GTPase binding, Rho-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ROCK2 itself. We selected most functions ROCK2 had, and list some proteins which have the same functions with ROCK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MCMDC2; MCM8; KIF25; SHPRH; FIGNL1; ADCY8; NAIP6; CFTR; SIK2; ITM2C
Function Rho GTPase binding
Related Protein ROCK2; CSDA; DOCK9; DIAPH1; DIAPH3; PFN1; DOCK11; FLNA; ECT2; DIAP3
Function Rho-dependent protein serine/threonine kinase activity
Related Protein ROCK2
Function metal ion binding
Related Protein ZFP346; NRXN3B; RBM4B; ZNF287; ARAP3; APLF; ACLYA; DNAJA3; ZBTB48; LIG4
Function poly(A) RNA binding
Related Protein XRN2; ZC3H18; SNRNP40; PTBP1; FLYWCH2; IGF2BP1; DCD; EXOSC10; UBE2I; MRPL15
Function protein binding
Related Protein PLD1; RAD17; CLDN8; FBXO45; VASP; MYBPC1; PHF10; TRAF6; TXNDC11; ECSIT
Function protein serine/threonine kinase activity
Related Protein EIF2AK2; STK11; MAP4K1; MAP2K4; STK35L; MKNK1; BMPR1AB; MAP3K4; PHKG1A; CSNK1G3
Function structural molecule activity
Related Protein LMNTD1; CLDN4; KRT85; MAP7; KRTAP3-1; KRT28; PGM5; GNL1; CLDNE; BVES

Interacting Protein

ROCK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ROCK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ROCK2.
NFKBIA; PPP1R14B; 15777285; STK16; NCL; IKBKE; purvalanol b; STAU1; Rock1; SNW1; FLOT2; N; CDC5L

ROCK2 Related Articles

Gerarduzzi, C; He, QW; et al. Prostaglandin E-2-Dependent Blockade of Actomyosin and Stress Fibre Formation Is Mediated Through S1379 Phosphorylation of ROCK2. JOURNAL OF CELLULAR BIOCHEMISTRY 115:1516-1527(2014).
Huang, P; Wang, J; et al. The effects of erythropoietin on RhoA/Rho-associated kinase expression in rat retinal explants cultured with glutamate. MOLECULAR MEDICINE REPORTS 6:662-666(2012).