ROCK2

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ROCK2

Official Full Name Rho-associated, coiled-coil containing protein kinase 2
Background The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]
Synonyms ROCK2; Rho-associated, coiled-coil containing protein kinase 2; ROCK-II; rho-associated protein kinase 2; p164 ROCK-2; rho-associated, coiled-coil-containing protein kinase II;
    • Species :
    • Human
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Insect cells
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ROCK2-1879H Recombinant Human ROCK2 Protein, His-tagged Insect cells His
    Human ROCK2-1878H Recombinant Human ROCK2 protein, His & T7-tagged E.coli His/T7
    Human ROCK2-2255HCL Recombinant Human ROCK2 293 Cell Lysate HEK293 N/A
    Human ROCK2-26H Recombinant Human ROCK2 protein, GST-tagged Insect Cell GST
    Human ROCK2-30955TH Recombinant Human ROCK2 N/A
    Human ROCK2-421H Recombinant Human ROCK2, GST-tagged, Active Sf9 Insect Cell GST
    Human ROCK2-672H Recombinant Human ROCK2 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ROCK2-712H Recombinant Human ROCK2, GST-His Sf9 Insect Cell GST
    Rhesus Macaque ROCK2-3952R Recombinant Rhesus monkey ROCK2 Protein, His-tagged Mammalian Cell His

    ROCK2 involved in several pathways and played different roles in them. We selected most pathways ROCK2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with ROCK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cGMP-PKG signaling pathway PLCB2; SLC25A5; NFATC2; Adcy4; RGS2; AKT1; GTF2I; NFATC4; PLCB1; CALM2
    cAMP signaling pathway ATP2B1; PIK3CB; GABBR1; NPY; PIK3CG; HTR6; SLC9A1; ACOX3; ATP1B2; NFKB1
    Chemokine signaling pathway SHC4; HCK; ARRB1; CXCR1; PRKCB; PXN; CX3CR1; CXCL13; BRAF; CCR10
    Sphingolipid signaling pathway PIK3CD; NRAS; TRAF2; LASS4; PLCB1; S1PR2; TRADD; MAPK10; LASS5; SPTLC3
    Vascular smooth muscle contraction PRKCG; PLA2G4AA; MYL6B; ADRA1BB; PRKCB; MYLK4; CALM1A; GNA13A; MAP2K1; CALM
    Wnt signaling pathway FZD8A; RHOAB; VANGL2; CXXC4; ROCK2; PPP3R1; WNT8A; CTNNBIP1; SMAD4; FZD2
    Axon guidance CD24; FRS3; DPYSL5; ACTR2B; JAK2; ARPC1A; ARPC5; NEFLB; SCN3B; JAK3
    Focal adhesion LAMA3; PIK3CB; THBS3; IGF1R; AKT2L; CDC42L2; COL6A2; COL6A5; CAPN2B; PPP1CAB
    Platelet activation VAMP8; COL27A1; MAPK12; PPP1R12A; GNAQ; STIM1; VWF; FYN; PIK3R1; GNAI1
    Leukocyte transendothelial migration THY1; OCLN; RAC1; CYBA; ACTN3; NCF4; CLDN4; CLDN3; ACTG1; ARHGAP5
    Regulation of actin cytoskeleton PIK3R2; FGF5; PTK2AA; MSNA; PIK3R3A; ITGA2; PIP5KL1; Itgam&Itgb2; FGFR1A; FGF10
    Oxytocin signaling pathway CAMKK1; ROCK2; CAMK1G; ACTG1; FOS; NFATC3; CAMK2A; MEF2C; CALM4; RYR1
    Pathogenic Escherichia coli infection ROCK2; TUBA4A; CTTN; LY96; TUBB7P; CD14; TUBB2A; TUBB6; CDH1; ARPC5L
    Shigellosis WAS; MAPK11; ROCK2; BTRC; PFN1; ITGB1; IKBKB; SRC; NFKBIB; ACTB
    Salmonella infection CDC42; RAB7B; CXCL3; KLC1A; IFNGR1; RHOGB; FLNC; MAPK3; NFKB1; MAPK8A
    Pathways in cancer BIRC2; GNAI2; RUNX1; LAMB2; CKS2; LAMC2; WNT7A; GNAS; WNT3; GNA12
    Proteoglycans in cancer GRB2; ERBB2; Casp3; COL21A1; RAC1; PIK3R5; VEGFA; GPC1; CCND1; WNT4

    ROCK2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by ROCK2 itself. We selected most functions ROCK2 had, and list some proteins which have the same functions with ROCK2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding SEPHS1; ULK1; GM7168; DHX32A; ABCA9; ATP6V1AA; GTF2F2A; CLK2B; ATP2B1; PSTK
    Rho GTPase binding DIAPH1; ANTXR2A; DOCK10; IQGAP3; PFN1; FLNA; ARHGEF2; ECT2; DIAPH3; AKAP13
    Rho-dependent protein serine/threonine kinase activity ROCK2
    metal ion binding TRAFD1; PHF23A; BRCC3; EGLN1B; SMAP1; TROVE2; PDP2; ZFP579; BTR22; GZF1
    poly(A) RNA binding CLTC; TCP1; ZFP598; C14orf21; FKBP4; TNPO1; HSPA8; KCTD12; PDIA4; CNBP
    protein binding RBMX2; PLCG1; FAM65B; SIX1; EHHADH; SRM; PTPRZ1; PYCRL; GRIK5; PHB
    protein serine/threonine kinase activity MARK4; STK32B; TAF1L; AKT1; PBK; SIK3; BSK146; PRKCA; CSNK1A1; DCLK2
    structural molecule activity KRTAP3-2; IVL; COL4A3; LCE4A; KRT34; VCLA; KRT1; LCE3D; KRTAP11-1; TUBA1A

    ROCK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ROCK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ROCK2.

    NFKBIA; PPP1R14B; 15777285; STK16; NCL; IKBKE; purvalanol b; STAU1; Rock1; SNW1; FLOT2; N; CDC5L

    Gerarduzzi, C; He, QW; et al. Prostaglandin E-2-Dependent Blockade of Actomyosin and Stress Fibre Formation Is Mediated Through S1379 Phosphorylation of ROCK2. JOURNAL OF CELLULAR BIOCHEMISTRY 115:1516-1527(2014).
    Huang, P; Wang, J; et al. The effects of erythropoietin on RhoA/Rho-associated kinase expression in rat retinal explants cultured with glutamate. MOLECULAR MEDICINE REPORTS 6:662-666(2012).

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