timp1
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  • Official Full Name
  • TIMP metallopeptidase inhibitor 1
  • Background
  • This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TIMP1; TIMP metallopeptidase inhibitor 1; EPA; EPO; HCI; CLGI; TIMP; metalloproteinase inhibitor 1; TIMP-1; collagenase inhibitor; erythroid potentiating activity; erythroid-potentiating activity; fibroblast collagenase inhibitor; tissue inhibitor of metalloproteinases 1
Cat.#:TIMP1-1034MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse TIMP1 Protein, His-tagged
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Cat.#:TIMP1-1688HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human TIMP Metallopeptidase Inhibitor 1
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Cat.#:TIMP1-001HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TIMP1, MIgG2a Fc-tagged
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Cat.#:TIMP1-002HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TIMP1, HIgG1 Fc-tagged
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Cat.#:TIMP1-2530HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TIMP Metallopeptidase Inhibitor 1
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Cat.#:TIMP1-261HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TIMP1 Protein, Fc-tagged
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Cat.#:TIMP1-287HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human metallopeptidase inhibitor 1, His-tagged
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Cat.#:TIMP1-2886HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TIMP Metallopeptidase Inhibitor 1
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Cat.#:TIMP1-30303THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TIMP1
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Cat.#:TIMP1-30304THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TIMP1, His-tagged
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Cat.#:TIMP1-30841THTag:MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TIMP1, MBP-tagged
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Cat.#:TIMP1-3194HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human TIMP1, None tagged
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Cat.#:TIMP1-3241HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TIMP1, His-tagged
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Cat.#:TIMP1-4764HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TIMP Metallopeptidase Inhibitor 1, His-tagged
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Cat.#:TIMP1-601HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human TIMP1 Protein, His-tagged
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Cat.#:TIMP1-77HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TIMP1, His-tagged
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Cat.#:TIMP1-878HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TIMP1, His tagged
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Cat.#:Timp1-2788MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Timp1 protein, His-tagged
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Cat.#:Timp1-3285MTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Timp1, None tagged
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Cat.#:Timp1-69MTag:His
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse Timp1 protein, His-tagged
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Cat.#:TIMP1-1072RTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat TIMP1 Protein
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Cat.#:Timp1-1798RTag:N/A
Source (Host):NS0Species:Rat
Product nameRecombinant Rat TIMP Metallopeptidase Inhibitor 1
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Cat.#:Timp1-2790RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Timp1 protein, His-tagged
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Cat.#:TIMP1-6076RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TIMP1 Protein
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Cat.#:Timp1-61RTag:His
Source (Host):Insect cellSpecies:Rat
Product nameRecombinant Rat Timp1 protein, His-tagged
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Cat.#:TIMP1-4722RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TIMP1 Protein, His-tagged
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Cat.#:TIMP1-2786DTag:His
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog TIMP1 protein, His-tagged
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Cat.#:TIMP1-2791RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit TIMP1 protein, His-tagged
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Cat.#:TIMP1-2787HTag:His/GST
Source (Host):E. coliSpecies:Horse
Product nameRecombinant Horse TIMP1 protein, His & GST-tagged
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Cat.#:TIMP1-2789STag:His/T7
Source (Host):E. coliSpecies:Sheep
Product nameRecombinant Sheep TIMP1 protein, His & T7-tagged
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Cat.#:TIMP1-5140HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TIMP Metallopeptidase Inhibitor 1
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Cat.#:TIMP1-30840THTag:N/A
Source (Host):Human fibroblastsSpecies:Human
Product nameNative Human TIMP1
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Cat.#:TIMP1-92HTag:
Source (Host):Species:Human
Product nameNative Human TIMP-1
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Cat.#:TIMP1-91BTag:
Source (Host):Species:Bovine
Product nameNative Bovine Thrombin
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Cat.#:TIMP1-2678HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TIMP1 cell lysate
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Cat.#:TIMP1-2376MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse TIMP1 cell lysate
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Cat.#:TIMP1-1490RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat TIMP1 cell lysate
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Involved Pathway

TIMP1 involved in several pathways and played different roles in them. We selected most pathways TIMP1 participated on our site, such as HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TIMP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
HIF- signaling pathway
ENO3; LTBR; PDHB; GAPDH; ANGPT2; GM5506; ALDOA; AKT2; INS2; RPS6

Protein Function

TIMP1 has several biochemical functions, for example, cytokine activity, growth factor activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TIMP1 itself. We selected most functions TIMP1 had, and list some proteins which have the same functions with TIMP1. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein GDF3; IFNA4; LEFTY1; LIF; BMP5; IL13; GM13289; IFNB1; IFNG1-2; RNF207B
Function growth factor activity
Related Protein CDNF; GDF9; Fgf15; IL34; GDF15; GDF11; NGF; NRG2; EGF; RABEP2
Function metal ion binding
Related Protein ZNF683; GMEB1; RNF144AB; KDM2BA; SLC2A4RG; RPS27A; FBXO5; KEL; KDM6A; MTMR4
Function metalloendopeptidase inhibitor activity
Related Protein SPOCK3; TIMP2A; TIMP4; TIMP3; TIMP2; FETUB; WFIKKN2; NGF; COL4A3; BST2
Function protease binding
Related Protein TNF; ITGA3; CFLAR; SERPINB6; TNFAIP3; TTN; FAP; A2M; BDKRB2; LCN2
Function protein binding
Related Protein TTC17; SNX1; CALR; SMG9; NCAM1A; HSPA8; FBXW11; KEL; KDR; GBP1

Interacting Protein

TIMP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIMP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TIMP1.
CD63; MMP9; RECQL5; EEF1B2; SUMO2; ECH1

TIMP1 Related Articles

Shi, M; Movius, J; et al. Cerebrospinal Fluid Peptides as Potential Parkinson Disease Biomarkers: A Staged Pipeline for Discovery and Validation. MOLECULAR & CELLULAR PROTEOMICS 14:544-555(2015).
Krabben, A; Huizinga, TWJ; et al. Biomarkers for Radiographic Progression in Rheumatoid Arthritis. CURRENT PHARMACEUTICAL DESIGN 21:147-169(2015).