tnfsf13
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  • Official Full Name
  • tumor necrosis factor (ligand) superfamily, member 13
  • Background
  • The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
  • Synonyms
  • TNFSF13; tumor necrosis factor (ligand) superfamily, member 13; tumor necrosis factor ligand superfamily member 13; APRIL; CD256; a proliferation-inducing ligand; tumor necrosis factor-like protein ZTNF2; tumor necrosis factor-related death ligand-1; TNF-
Cat.#:TNFSF13-26HTag:His-FLAG
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF13 Protein, His-FLAG-tagged
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Cat.#:TNFSF13-386HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF13 Protein, Fc-tagged
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Cat.#:TNFSF13-2028MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse TNFSF13 Protein
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Cat.#:APRIL-3591HTag:
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human APRIL
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Cat.#:TNFSF13-1045HTag:HA
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF13 protein, HA-tagged
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Cat.#:TNFSF13-2091HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF13, FLAG-tagged
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Cat.#:TNFSF13-2141HTag:Fc
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human TNFSF13, Fc Chimera
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Cat.#:TNFSF13-348HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human TNFSF13
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Cat.#:TNFSF13-349HTag:HA
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF13, HA-tagged
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Cat.#:TNFSF13-399HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFSF13, FLAG-tagged
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Cat.#:TNFSF13-505HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human tumor necrosis factor (ligand) superfamily, member 13, T7 tagged
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Cat.#:TNFSF13-5106HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF13, T7-tagged
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Cat.#:TNFSF13-875HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF13 Protein, GST-His-tagged
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Cat.#:Tnfsf13-1744MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tnfsf13 protein, His-tagged
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Cat.#:Tnfsf13-696MTag:
Source (Host):CHO cellsSpecies:Mouse
Product nameRecombinant Mouse Tnfsf13
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Cat.#:Tnfsf13-8691MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tnfsf13, Fc-tagged
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Cat.#:Tnfsf13-930MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Murine Tnfsf13
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Cat.#:Tnfsf13-931MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tnfsf13, Fc tagged
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Cat.#:Tnfsf13-933MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tnfsf13
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Cat.#:Tnfsf13-936MTag:Flag
Source (Host):Species:Mouse
Product nameRecombinant Mouse Tnfsf13, Flag-tagged
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Cat.#:Tnfsf13-16RTag:
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat Tnfsf13 protein
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Cat.#:Tnfsf13-17RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tnfsf13 protein, His-tagged
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Cat.#:TNFSF13-1635RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TNFSF13 Protein
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Cat.#:TNFSF13-25RTag:His
Source (Host):E. coliSpecies:Rhesus monkey
Product nameRecombinant Rhesus monkey TNFSF13 protein, His-tagged
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Cat.#:TNFSF13-4873RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TNFSF13 Protein, His-tagged
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Cat.#:TNFSF13-1743DTag:His/S
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog TNFSF13 protein, His & S-tagged
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Cat.#:TNFSF13-7646ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TNFSF13
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Cat.#:TNFSF13-1742CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle TNFSF13 protein, His & T7-tagged
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Cat.#:TNFSF13-350HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tumor Necrosis Factor (Ligand) Superfamily, Member 13
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Cat.#:TNFSF13-351HTag:N/A
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human Tumor Necrosis Factor (Ligand) Superfamily, Member 13
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Cat.#:TNFSF13-1346MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse TNFSF13 cell lysate
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Involved Pathway

TNFSF13 involved in several pathways and played different roles in them. We selected most pathways TNFSF13 participated on our site, such as Cytokine-cytokine receptor interaction, Intestinal i, ne network for IgA production, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFSF13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CSF3R; CCL25B; THPO; CSF3; IFNA12; TNFRSF14; IL1A; CXCR4; IL18RAP; EPO
Intestinal i
HLA-DRB4; BMA1; Icosl; HLA-DOA; CD40LG; H2-AB1; CD86; CXCR4; IL-15RA; MHC2DAB
ne network for IgA production
HLA-DMA; HLA-DRB4; IL-15RA; H2-AA; ITGB7; BMA1; HLA-DQA2; LTBR; CCL28; HLA-DPB1
Rheumatoid arthritis
ATP6V0B; IL17A; CD80; HLA-DQA1; TGFB2; Ccl12; IL-8; ATP6V1G2; HLA-DRB4; TNFRSF11A

Protein Function

TNFSF13 has several biochemical functions, for example, cytokine activity, receptor binding, tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFSF13 itself. We selected most functions TNFSF13 had, and list some proteins which have the same functions with TNFSF13. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein IFNPHI1; TNFB; IL1RN; NDR2; SCG2; CCL20B; BMP2; IFNA21; VEGFA; FLT3LG
Function receptor binding
Related Protein HSPA1B; TNFSF14; HACL1; AGXT; HLA-F; DDO; GRP; BLK; GLA; CRH
Function tumor necrosis factor receptor binding
Related Protein FADD; TNFSF4; TNFSF15; FASLG; TRAF2; TNF; TNFSF10L3; TNFSF11; CD70; TRAF4

Interacting Protein

TNFSF13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFSF13 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFSF13.
TNFRSF13B; KRAS; PIK3CA; CAMK1D

TNFSF13 Related Articles

Osorio, C; Chacon, PJ; et al. Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL. MOLECULAR AND CELLULAR NEUROSCIENCE 59:24-36(2014).
Kutukculer, N; Gulez, N; et al. Three Different Classifications, B Lymphocyte Subpopulations, TNFRSF13B (TACI), TNFRSF13C (BAFF-R), TNFSF13 (APRIL) Gene Mutations, CTLA-4 and ICOS Gene Polymorphisms in Turkish Patients with Common Variable Immunodeficiency. JOURNAL OF CLINICAL IMMUNOLOGY 32:1165-1179(2012).

TNFSF13 Related Gene Family

TNF