|Official Full Name||Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)|
|Background||Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 Nm. This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed.|
|Synonyms||TFPI; EPI; TFI; LACI; TFPI1; tissue factor pathway inhibitor; anti-convertin; extrinsic pathway inhibitor|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
Tfpi involved in several pathways and played different roles in them. We selected most pathways Tfpi participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tfpi were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Complement and coagulation cascades||THBD; C8A; Serpina1c; F12; CD46; C8G; C7; C4BP; CPB2; C1RA|
Tfpi has several biochemical functions, for example, endopeptidase inhibitor activity, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Tfpi itself. We selected most functions Tfpi had, and list some proteins which have the same functions with Tfpi. You can find most of the proteins on our site.
|endopeptidase inhibitor activity||CST7; PCSK1N; SERPINA1D; WFDC2; Serpina1c; C5; C3P1; C4A; MUG1; C3B.2|
|serine-type endopeptidase inhibitor activity||SERPINB13; HRG; A1i3; PCSK1NL; PAPLNB; RECK; SERPINA1; SERPINE1; SPINT4; ITIH3A|
Tfpi has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tfpi here. Most of them are supplied by our site. Hope this information will be useful for your research of Tfpi.