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Official Full Name Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Background Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 Nm. This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed.
Synonyms TFPI; EPI; TFI; LACI; TFPI1; tissue factor pathway inhibitor; anti-convertin; extrinsic pathway inhibitor
    • Species :
    • Human
    • Mouse
    • Rabbit
    • Rat
    • Rhesus macaque
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • NS0
    • Rabbit
    • Tag :
    • His
    • GST
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TFPI-876H Recombinant Human TFPI Protein, His-tagged, Biotinylated HEK293 His
    Human TFPI-105H Recombinant Human TFPI protein, His-tagged E.coli His
    Human TFPI-106H Recombinant Human TFPI protein, His/GST-tagged E.coli His/GST
    Human TFPI-107H Recombinant Human TFPI protein, His/GST-tagged E.coli His/GST
    Human TFPI-2333H Recombinant Human TFPI, His-tagged E.coli His
    Human TFPI-2746HCL Recombinant Human TFPI cell lysate Human Cell N/A
    Human TFPI-707H Recombinant Human TFPI Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TFPI-875H Recombinant Human TFPI protein, His-tagged HEK293 His
    Mouse CAB11612RM Rabbit Monoclonal Antibody to Mouse Tissue Factor Pathway Inhibitor Rabbit N/A
    Mouse CAB11613RM Rabbit Monoclonal Antibody to Mouse Tissue Factor Pathway Inhibitor Rabbit N/A
    Mouse TFPI-2843MCL Recombinant Mouse TFPI cell lysate Human Cell N/A
    Mouse Tfpi-574M Recombinant Mouse Tfpi Protein, His-tagged E.coli His
    Mouse Tfpi-874M Recombinant Mouse Tfpi, His tagged Human Cell His
    Mouse Tfpi-981M Recombinant Mouse Tfpi Protein, His-tagged NS0 His
    Rat Tfpi-575R Recombinant Rat Tfpi Protein, His-tagged E.coli His
    Rhesus macaque TFPI-4683R Recombinant Rhesus macaque TFPI protein, His-tagged HEK293 His
    Rabbit TFPI-576R Recombinant Rabbit TFPI Protein, His/GST-tagged E.coli His/GST

    Tfpi involved in several pathways and played different roles in them. We selected most pathways Tfpi participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tfpi were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Complement and coagulation cascades THBD; C8A; Serpina1c; F12; CD46; C8G; C7; C4BP; CPB2; C1RA

    Tfpi has several biochemical functions, for example, endopeptidase inhibitor activity, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Tfpi itself. We selected most functions Tfpi had, and list some proteins which have the same functions with Tfpi. You can find most of the proteins on our site.

    Function Related Protein
    endopeptidase inhibitor activity CST7; PCSK1N; SERPINA1D; WFDC2; Serpina1c; C5; C3P1; C4A; MUG1; C3B.2
    serine-type endopeptidase inhibitor activity SERPINB13; HRG; A1i3; PCSK1NL; PAPLNB; RECK; SERPINA1; SERPINE1; SPINT4; ITIH3A

    Tfpi has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tfpi here. Most of them are supplied by our site. Hope this information will be useful for your research of Tfpi.


    Luna, E; Agrawal, P; et al. Evaluation of Immunostimulatory Potential of Branded and US-Generic Enoxaparins in an In Vitro Human Immune System Model. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS 21:211-222(2015).
    Franchini, M; et al. Next-generation treatment of acquired hemophilia A. EXPERT OPINION ON ORPHAN DRUGS 3:245-251(2015).

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