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Recombinant Human TFPI protein, His-Avi-tagged, Biotinylated

Cat.No. : TFPI-646HB
Product Overview : Biotinylated Recombinant Human TFPI Protein is expressed from Expi293 with a His and Avi Tag at the C-terminal. It contains Asp29-Lys282.
  • Specification
  • Gene Information
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Description : Oestrogens influence the pathophysiology and development of hormone-sensitive cancers, such as breast cancer. Tissue factor pathway inhibitor (TFPI) is a serine protease inhibitor of the extrinsic coagulation pathway and has recently been associated with breast cancer cell development.
Source : HEK293
Species : Human
Tag : His-Avi
Form : Supplied as 0.22μm filtered solution in PBS(pH 7.4).
Molecular Mass : The protein has a predicted MW of 32.1 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result.
Protein length : Asp29-Lys282
Endotoxin : Less than 0.05 EU per μg by the LAL method.
Purity : >95% as determined by Bis-Tris PAGE; >95% as determined by HPLC
Storage : The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
Gene Name : TFPI
Official Symbol : TFPI
Synonyms : LACI, TFPI1, EPI, TFI
Gene ID : 7035
mRNA Refseq : NM_001032281.3
Protein Refseq : NP_001027452.1
MIM : 152310
UniProt ID : P10646

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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In which medical scenarios is monitoring TFPI protein particularly crucial? 06/20/2022

Monitoring TFPI levels is crucial in patients with a history of thrombotic events, individuals at high risk of clotting disorders, and those undergoing anticoagulant therapy.

Can TFPI protein be explored in the context of preventing complications in surgery or other medical procedures? 01/23/2022

Research suggests that manipulating TFPI levels might be explored to reduce thrombotic complications in surgical and medical settings, potentially improving patient outcomes.

Are there any challenges or risks associated with manipulating TFPI levels for therapeutic purposes? 07/27/2019

Manipulating TFPI levels may pose challenges, as it could potentially lead to bleeding disorders. Balancing the anticoagulant effects with the risk of bleeding is a critical consideration.

How does TFPI contribute to the regulation of inflammation in addition to its anticoagulant properties? 03/11/2017

TFPI has anti-inflammatory effects by inhibiting the activation of immune cells and downregulating inflammatory mediators. This dual role makes it a potential therapeutic target in conditions involving both coagulation and inflammation.

In what ways can TFPI protein be a target for drug development in the pharmaceutical industry? 04/22/2016

Pharmaceutical research can explore the development of drugs that either enhance or mimic the activity of TFPI, providing new avenues for anticoagulant therapies.

Customer Reviews (3)

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Reviews
03/04/2022

    This property is particularly beneficial for long-term trials or experiments with extended durations, ensuring consistent performance throughout the entire study period.

    05/31/2020

      Its purity and consistency have been extensively validated, minimizing any potential variability that could affect trial outcomes.

      07/22/2016

        Their extensive technical expertise and assistance are invaluable in overcoming any challenges that may arise during the experimental process.

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