TFRC
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Official Full Name
transferrin receptor
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Overview
Transferrin receptor protein 1 (TfR1) also known as (Cluster of Differentiation 71) (CD71) is a protein that in humans is encoded by the TFRC gene. TfR1 is required for iron delivery from transferrin to cells -
Synonyms
TFRC; transferrin receptor; T9; TR; TFR; p90; CD71; TFR1; TRFR;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Transfected Stable Cell Lines
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus
- Cynomolgus Monkey
- Cynomolgus/Rhesus
- Horse
- Human
- Marmoset
- Mouse
- Pig
- Rat
- 293F
- E. coli
- E.coli
- HEK293
- HEK293F
- HEK293T
- Human Cell
- Human plasma
- Human Plasma
- Human Serum
- Insect Cell
- Mammalian Cell
- Mammalian cells
- C
- His
- Fc
- Flag
- FLAG
- HIgG1 Fc
- His (Fc)
- Avi
- His(C
- ter)
- His|GST
- His|S
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- TFRC Related Research Area
TFRC involved in several pathways and played different roles in them. We selected most pathways TFRC participated on our site, such as HIF- signaling pathway, Endocytosis, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with TFRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIF- signaling pathway | PIK3R5;INS1;PFKL;RPS6;EGLN1;GM5506;PIK3CG;CAMK2A;PGK1 |
| Endocytosis | ARPC2;ASAP2B;VPS24;EHD4;HLA-G;LDLRA;GRK5;GBF1;ARPC4L |
| Phagosome | HLA-G;ATP6V0A1B;ITGB3B;HLA-C;CCDC102A;CTSLA;TLR2-2;STX18;THBS3 |
| Hematopoietic cell lineage | GYPA;IL1A;ITGB3;CD8B1;CD37;CD4;CD44;CD1A;CD7 |
TFRC has several biochemical functions, for example, Hsp70 protein binding, chaperone binding, double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TFRC itself. We selected most functions TFRC had, and list some proteins which have the same functions with TFRC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Hsp70 protein binding | DNAJB2;STIP1;PARK2;L7RN6;ST13;RPS3;METTL21A;TFRC;DNAJA1 |
| chaperone binding | GNB5;FGB;TRP53;SLC25A17;SERPINA7;BAK1;GRPEL1;DNAJB2;DNAJB7 |
| double-stranded RNA binding | VIM;LSM14A;HSPD1;STRBP;ZNF346;APTX;AGO3;DGCR8;MSN |
| glycoprotein binding | Serpina1b;RASA1;ERBB2;VWF;SERPINA1A;CALR;CSNK1D;SERPINA1E;DNAJC5 |
| identical protein binding | CLDN17;IFI203;USP15;BCAT1;AIRE;ST13;ERN1;FADD;CLDN3 |
| poly(A) RNA binding | RPL5A;DDX6;HIST1H1B;RPL7A;S100A4;NOP16;RBM6;RPS3;XRN1 |
| protein binding | RFPL4;RPL7;CFTR;FRS2;ITGAX;EIF4EBP1;ANXA10;INO80;PARVA |
| protein homodimerization activity | MYH9;SP1;ALS2;UGT1A2;C16orf89;UNC13A;CSF1R;CPOX;CCL5 |
| transferrin receptor activity | TFRC;TFR1A;TFR1B;TFR2 |
| transferrin transmembrane transporter activity | TFRC;SLC11A2 |
| virus receptor activity | CLEC4M;SCARB1;TNFRSF4;NPC1;GYPA;HSPA1B;LAMP1;LDLR;ACE2 |
TFRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFRC here. Most of them are supplied by our site. Hope this information will be useful for your research of TFRC.
SH3BP4; HFE; SGTA; ALB; ERBB2; VCAM1
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, TFRC's presence on cell surfaces has been exploited for the development of targeted drug delivery systems, especially for delivering drugs to cancer cells.
Yes, some experimental therapies aim to target TFRC on cancer cells, such as antibody-drug conjugates (ADCs) and small-molecule inhibitors.
Yes, dysregulation of TFRC expression or function can be associated with various medical conditions, including anemia, cancer, and neurodegenerative diseases.
Researchers use techniques like immunohistochemistry and molecular assays to study TFRC expression levels in patient samples. This helps in diagnosis and prognosis.
Understanding TFRC expression in the context of anemia can help identify the underlying causes and guide treatment strategies to improve iron uptake.
Customer Reviews (3)
Write a reviewIn addition to the advantages of GAD1 protein itself, the manufacturer can play a crucial role in supporting the research efforts.
This quality control is essential for obtaining reliable and reproducible data, as any variability in protein quality can introduce confounding factors into experiments.
This versatility enables researchers to explore GAD1's function and role in a range of biological processes, making it a valuable tool across diverse research fields.
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