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Recombinant Mouse Tfrc protein, His-tagged

Cat.No. : Tfrc-1567M
Product Overview : Recombinant Mouse Tfrc aa. (Arg572~Trp757) fused with N-terminal His tag was produced in E. coli cells.
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  • Gene Information
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Description : This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis.
Source : E. coli
Species : Mouse
Tag : His
Form : Freeze-dried powder
Molecular Mass : 29kDa as determined by SDS-PAGE reducing conditions.
Protein length : Arg572~Trp757
Endotoxin : <1.0EU per 1µg (determined by the LAL method).
Purity : >92%
Characteristic : The isoelectric point is 6.5.
Applications : SDS-PAGE; WB; ELISA; IP; CoIP; ReporterAssays; Purification; Amine Reactive Labeling.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Concentration : 200µg/mL
Storage buffer : PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and Proclin300.
Reconstitution : Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Gene Name : Tfrc transferrin receptor [ Mus musculus (house mouse) ]
Official Symbol : Tfrc
Synonyms : TR; TFR; p90; CD71; TFR1; Trfr; Mtvr1; 2610028K12Rik; E430033M20Rik; mammary tumor virus receptor 1; transferrin receptor protein 1
Gene ID : 22042
mRNA Refseq : NM_011638.4
Protein Refseq : NP_035768.1
UniProt ID : Q62351

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can TFRC be used to develop targeted drug delivery systems? 09/13/2022

Yes, TFRC's presence on cell surfaces has been exploited for the development of targeted drug delivery systems, especially for delivering drugs to cancer cells.

Are there any therapies that target TFRC in cancer treatment? 11/17/2020

Yes, some experimental therapies aim to target TFRC on cancer cells, such as antibody-drug conjugates (ADCs) and small-molecule inhibitors.

Are there any clinical conditions associated with TFRC protein dysregulation? 09/19/2017

Yes, dysregulation of TFRC expression or function can be associated with various medical conditions, including anemia, cancer, and neurodegenerative diseases.

How is TFRC protein studied in clinical research and diagnostics? 10/03/2016

Researchers use techniques like immunohistochemistry and molecular assays to study TFRC expression levels in patient samples. This helps in diagnosis and prognosis.

How can TFRC be relevant in the treatment of iron-deficiency anemia? 01/02/2016

Understanding TFRC expression in the context of anemia can help identify the underlying causes and guide treatment strategies to improve iron uptake.

Customer Reviews (3)

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Reviews
09/06/2021

    In addition to the advantages of GAD1 protein itself, the manufacturer can play a crucial role in supporting the research efforts.

    04/19/2018

      This quality control is essential for obtaining reliable and reproducible data, as any variability in protein quality can introduce confounding factors into experiments.

      01/27/2017

        This versatility enables researchers to explore GAD1's function and role in a range of biological processes, making it a valuable tool across diverse research fields.

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