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VEGFC

  • Official Full Name

    vascular endothelial growth factor C

  • Overview

    The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]
  • Synonyms

    VEGFC; vascular endothelial growth factor C; VRP; Flt4-L; FLT4 ligand DHM; vascular endothelial growth factor-related protein; VEGF-C; AW228853;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Dog
  • Human
  • Mouse
  • Mouse/Rat
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • Human
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Yeast
  • C
  • His
  • Fc
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human VEGFC-133H Active Recombinant Human VEGFC Protein, His-tagged CHO His Thr103-Arg227
Human VEGFC-31733TH Recombinant Human VEGFC E.coli N/A
Human VEGFC-615H Recombinant Human Vascular Endothelial Growth Factor C, His-tagged E.coli His
Human VEGFC-211H Active Recombinant Human VEGFC, His tagged HEK293 His Thr103-Arg227
Human VEGFC-641H Recombinant Human Vascular Endothelial Growth Factor C Human N/A
Human VEGFC-8329H Recombinant Human VEGFC HEK293 N/A
Human VEGFC-533H Recombinant Human VEGFC, His-tagged Sf9 Insect Cell His
Human VEGFC-131H Recombinant Human VEGFC Protein, His-tagged HEK293 His Ala112-Arg227
Human VEGFC-352H Recombinant Human Vascular Endothelial Growth Factor C Mammalian cells N/A
Human VEGFC-157H Recombinant Human VEGFC HEK293 N/A
Human VEGFC-29H Recombinant Human VEGFC protein, His-tagged Insect Cell His
Human VEGFC-31451TH Recombinant Human VEGFC, Fc-tagged Fc
Human VEGFC-45H Recombinant Human Vascular Endothelial Growth Factor C, His- tagged Sf9 Insect Cell His
Human Vegfc-5345R Recombinant Rat Vascular Endothelial Growth Factor C, His-tagged Insect Cell His
Human VEGFC-604H Recombinant Human VEGFC protein, His & T7-tagged E.coli His/T7 Glu47~Trp413 (Accession # P49767)
Human VEGFC-2768HCL Recombinant Human VEGFC cell lysate Human Cell N/A
Human VEGFC-108H Active Recombinant Human VEGFC Protein E. coli
Human VEGFC-567H Recombinant Human VEGFC Protein, His-tagged HEK293F N-His Thr103-Arg227
Human VEGFC-160V Active Recombinant Human VEGFC Protein (126 aa) HEK293 126
Human VEGFC-4506H Recombinant Human VEGFC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human VEGFC-566H Recombinant Human VEGFC Protein, His-tagged E.coli N-His Glu47-Trp413
Human VEGFC-565H Recombinant Human VEGFC Protein HEK293 419
Human VEGFC-6559H Recombinant Human VEGFC Protein (Phe32-Arg227), C-His tagged Mammalian cells C-His Phe32-Arg227
Human VEGFC-4506H-B Recombinant Human VEGFC Protein Pre-coupled Magnetic Beads HEK293
Human VEGFC-6560H Recombinant Human VEGFC Protein (Glu47-Trp413), His tagged E.coli His Glu47-Trp413
Human VEGFC-5839H Recombinant Human VEGFC Protein(112-227aa), GST-tagged E. coli N-GST 112-227aa
Mouse Vegfc-605M Recombinant Mouse Vegfc protein, His-tagged E.coli His Ala108~Arg223
Mouse Vegfc-5535M Recombinant Mouse Vascular Endothelial Growth Factor C E.coli N/A
Mouse VEGFC-18006M Recombinant Mouse VEGFC Protein Mammalian Cell His
Mouse VEGFC-825M Recombinant Mouse VEGFC Protein (Ala108-Arg223), His-tagged HEK293 His Ala108-Arg223
Mouse VEGFC-10009M Recombinant Mouse VEGFC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse VEGFC-10009M-B Recombinant Mouse VEGFC Protein Pre-coupled Magnetic Beads HEK293
Mouse Vegfc-5545M Recombinant Mouse Vegfc protein, His-tagged Yeast His 108-223aa
Rat Vegfc-5536R Recombinant Rat Vascular Endothelial Growth Factor C Insect Cell N/A
Rat Vegfc-8713R Recombinant Rat Vegfc, Fc tagged Human Cell Fc
Rat Vegfc-46R Recombinant Rat Vascular Endothelial Growth Factor C, His-tagged Sf9 Insect Cell His
Rat Vegfc-606R Recombinant Rat Vegfc protein, His-tagged E.coli His Ala108~Arg223 (Accession # O35757)
Rat VEGFC-6515R Recombinant Rat VEGFC Protein Mammalian Cell His
Rat Vegfc-8714R Recombinant Rat Vegfc, His tagged Human Cell His
Rat Vegfc-534R Recombinant Rat Vegfc, His-tagged Sf9 Insect Cell His
Rat Vegfc-616R Recombinant Rat Vascular Endothelial Growth Factor C E.coli N/A
Rat Vegfc-454R Recombinant Rat Vascular Endothelial Growth Factor C Insect Cell N/A
Rat Vegfc-635R Recombinant Rat Vascular Endothelial Growth Factor C, His-tagged Insect Cell His
Rat VEGFC-1306RCL Recombinant Rat VEGFC cell lysate Human Cell N/A
Rat VEGFC-6171R Recombinant Rat VEGFC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat VEGFC-6171R-B Recombinant Rat VEGFC Protein Pre-coupled Magnetic Beads HEK293
Rabbit VEGFC-607R Recombinant Rabbit VEGFC protein, His & GST-tagged E.coli His/GST Ala111~Arg226 (Accession # G1TEN0)
Rabbit VEGFC-3375R Recombinant Rabbit VEGFC protein, His-tagged HEK293 His Ala111~Arg226
Dog VEGFC-602D Recombinant Dog VEGFC protein, His & T7-tagged E.coli His/T7 Ala112~Arg227 (Accession # E2QY17)
Cattle VEGFC-601C Recombinant Cattle VEGFC protein, His & T7-tagged E.coli His/T7 Ala113~Arg228 (Accession # Q9XS50)
Mouse/Rat VEGFC-1319M Acitve Recombinant Mouse/Rat VEGFC protein(Ala108-Arg223), Fc-tagged HEK293 N-Fc Ala108-Arg223
Mouse/Rat VEGFC-1148M Recombinant Mouse/Rat VEGFC protein(Ala108-Arg223), His-tagged HEK293 C-His Ala108-Arg223
Rhesus Macaque VEGFC-5153R Recombinant Rhesus monkey VEGFC Protein, His-tagged Mammalian Cell His
Rhesus Macaque VEGFC-4966R-B Recombinant Rhesus Macaque VEGFC Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque VEGFC-4966R Recombinant Rhesus Macaque VEGFC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish VEGFC-11752Z Recombinant Zebrafish VEGFC Mammalian Cell His
Chicken VEGFC-603C Recombinant Chicken VEGFC protein, His & T7-tagged E.coli His/T7 Ala212~Arg327 (Accession # E1C7C6)
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • VEGFC Related Articles
VEGFC-8.jpg

Fig1. Model endothelial cell displaying genes of the VEGF signalling pathway and the sites at which bevacizumab, sorafenib, sunitinib, brivanib and cilengitide are known to act. (Pictures from PHARMGKB)

What is VEGFC protein?

VEGFC (vascular endothelial growth factor C) gene is a protein coding gene which situated on the long arm of chromosome 4 at locus 4q34. The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. The VEGFC protein is consisted of 419 amino acids and its molecular mass is approximately 46.9 kDa.

What is the function of VEGFC protein?

VEGFC act as a growth factor in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. It may has functions in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults.

VEGFC Related Signaling Pathway

The VEGFR-2/3 signaling pathway, when combined with it, can activate the pathway, thereby promoting lymphangiogenesis and tumor metastasis. In the PI3K/Akt signaling pathway, VEGFC activates phosphatidylinositol 3-kinase (PI3K) through VEGFR-2, and then activates Akt, which is involved in the regulation of cell proliferation, survival and vascular permeability. In addition, there are MAPK/ERK signaling pathways, Notch signaling pathways and so on.

VEGFC Related Diseases

Overexpression of VEGFC is associated with angiogenesis and metastasis of malignant tumors, such as breast cancer, lung cancer, and colorectal cancer. It is also associated with lymphangiogenesis and lymph node metastasis, and overexpression of VEGFC can lead to abnormal lymphangiogenesis and lymph node enlargement. In addition, some other vascular diseases are associated, such as generalized vasodilatation, congenital lymphedema and so on.

VEGFC-7.jpg

Fig2. Expression patterns determining different types of metastases in EOC Tumour cells of patients with 'predominant retroperitoneal' metastases are characterised by a mesenchymal tumour type with low E-Cadherin and high VEGF-C and –D expression. (Sascha Kuerti, 2017)

Bioapplications of VEGFC

Using VEGFC's anti-angiogenic effect, researchers are exploring its use in the treatment of tumors, inhibiting tumor angiogenesis and stopping tumor growth and metastasis. At the same time, there are also some studies on the treatment of cardiovascular diseases such as myocardial infarction and arterial disease.

High Purity

High Bioactivity

VEGFC-2.jpg

Fig2. Activity Data. (VEGFC-566H)

Case Study 1: Omar García-Pérez, 2023

VEGFC-3.jpg

Fig1. VEGFC protein in CSCC tumors detected by immunofluorescence.

Case Study 2: Zhengmin Wang, 2021

VEGFC-4.jpg

Fig2. Various VEGF-positive bands in the GBM cell lysates were detected by pan-VEGF antibody, and the molecular weight ranged from 15 to 120 kDa.

VEGFC-5.jpg

Fig1. The upregulation of TAZ in endothelial cells by GBM-derived exosomes was not blocked by the standard therapeutic dose of bevacizumab, whereas a combination of the exosomal inhibitor (GW4869) and bevacizumab inhibited the growth of subcutaneously implanted GBM tumors in nude mice. (Zhengmin Wang, 2021)

VEGFC-6.jpg

Fig2. Blocking VEGF-C signaling reduces immune cells infiltration to endometriotic tissues. (Wan-Ning Li, 2020)

VEGFC involved in several pathways and played different roles in them. We selected most pathways VEGFC participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with VEGFC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayPDGFC;FGF13;PLA2G4D;GNG5;GNG7;GNB4;PIK3CA;RRAS;PLA2G1B
Rap signaling pathwayMAP2K2;FGF19;SIPA1L1;KRIT1;APBB1IP;ACTB;Fgf15;INS2;MRAS
Cytokine-cytokine receptor interactionIL8L2;CXCL2;IL2RG;CCL11;PDGFRA;ACVR2A;Ccl27a;PDGFC;TNFRSF10C
PIK-Akt signaling pathwayRAC1;LAMA5;FGFR1;GNG11;LAMA4;PIK3CB;LPAR4;Ifna15;PKN2
Focal adhesionFIGF;ITGB1B.2;ACTN4;DOCK1;RAP1AB;DIAPH1;DIAP1;COL27A1B;COL4A2
TNF signaling pathwayCCL20;PIK3CA;FAS;PIK3CD;DNM1L;CREB3L2;CXCL10;RPS6KA4;PIK3CG
Pathways in cancerWNT2B;CBLB;GLI2;STAT1;CYCS;RALBP1;RXRB;ARNT2;MTOR

VEGFC has several biochemical functions, for example, chemoattractant activity, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VEGFC itself. We selected most functions VEGFC had, and list some proteins which have the same functions with VEGFC. You can find most of the proteins on our site.

Function Related Protein
chemoattractant activityVEGFC;CCL15;BMP4;CXCL12A;HMGB2;FGF10;VEGFB;CXCL12B;MIF
growth factor activityKLK1B3;GDF15;GDF6B;LIF;CNTF;FGF6B;CXCL12;GDF9;CSPG5
protein bindingHTT;ETV5;RNH1;NAPA;DARS2;HTR6;SLC22A17;C21orf56;NDEL1
vascular endothelial growth factor receptor 3 bindingFIGF;VHL;VEGFC

VEGFC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VEGFC here. Most of them are supplied by our site. Hope this information will be useful for your research of VEGFC.

FLT4

Ma, J; Zhou, D; et al. Keratocytes Create Stromal Spaces to Promote Corneal Neovascularization Via MMP13 Expression. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55:-(2014).
Ikeda, K; Oki, E; et al. Intratumoral Lymphangiogenesis and Prognostic Significance of VEGFC Expression in Gastric Cancer. ANTICANCER RESEARCH 34:3911-3915(2014).
  • Q&As
  • Reviews

Q&As (7)

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What signaling mechanisms are involved in VEGFC and its receptor interactions? 05/21/2022

VEGFC primarily signals through its interactions with VEGFR-2 (Vascular Endothelial Growth Factor Receptor 2) and VEGFR-3. Upon binding to one of these receptors, VEGFC triggers receptor dimerization, leading to the activation of intracellular signaling pathways. This activation involves phosphorylation events and subsequent recruitment of downstream effectors, which ultimately regulate cellular responses such as proliferation, migration, and angiogenesis. The intricate signaling mechanisms underlying VEGFC-receptor interactions contribute to its functional versatility and provide potential targets for therapeutic interventions.

What is known about the structural characteristics of VEGFC and its precursor? 03/29/2022

VEGFC protein is derived from the conversion of proVEGFC precursor protein and comprises approximately 354 amino acid residues. Structurally, it consists of a signal sequence, an N-terminal domain, and a C-terminal VEGF homology domain. The signal sequence is involved in cellular localization and secretion processes, while the VEGF homology domain interacts with target receptors, mediating cellular proliferation and angiogenesis. Understanding the specific structural features is crucial for elucidating the functional properties and molecular interactions associated with VEGFC.

How does VEGFC contribute to pathological conditions, particularly in cancer? 12/06/2021

VEGFC's involvement in pathological conditions, including cancer, is extensively studied. The upregulation of VEGFC expression in tumor cells promotes angiogenesis and lymphangiogenesis within the tumor microenvironment. This enhanced blood and lymphatic vessel formation facilitates tumor growth, invasion, and metastasis. Moreover, VEGFC can induce lymphangiogenesis in sentinel lymph nodes, aiding cancer cell dissemination. Targeting VEGFC signaling pathways has emerged as a potential therapeutic strategy to inhibit tumor angiogenesis and lymphangiogenesis, highlighting the clinical significance of understanding the complex interplay between VEGFC and cancer progression.

What are the current therapeutic interventions targeting VEGFC and its downstream signaling pathways? 04/22/2021

Several therapeutic interventions targeting VEGFC and its downstream signaling pathways are under investigation. Anti-VEGFC monoclonal antibodies, VEGFR inhibitors, and small molecule inhibitors of VEGFC-mediated signaling have shown promise in preclinical and clinical studies. These interventions aim to disrupt the angiogenic and lymphangiogenic processes driven by VEGFC, thereby inhibiting tumor growth, metastasis, and other pathological conditions associated with VEGFC dysregulation. Additionally, exploring combinational approaches with existing therapies, such as chemotherapy and immunotherapy, holds potential for synergistic effects and improved treatment outcomes. Continued research efforts are focused on optimizing these interventions for clinical application and expanding the therapeutic repertoire for VEGFC-associated diseases.

Are there any known regulatory mechanisms that modulate VEGFC expression levels? 08/20/2020

Multiple regulatory mechanisms control VEGFC expression levels. Transcriptional regulation plays a significant role, with various transcription factors binding to the VEGFC promoter region to activate or suppress its transcription. Additionally, post-transcriptional regulation through microRNAs and RNA-binding proteins can modulate VEGFC mRNA stability and translation efficiency. Furthermore, environmental factors, such as hypoxia and inflammation, influence VEGFC expression by activating specific signaling pathways. Understanding the precise regulatory mechanisms is crucial for deciphering the intricate balance required for maintaining proper VEGFC levels and ensuring its functional integrity.

What are the clinical implications of VEGFC dysregulation? 05/08/2020

Dysregulation of VEGFC has been associated with various pathological conditions. Excessive VEGFC expression has been implicated in tumor angiogenesis, promoting the growth and spread of cancer cells by stimulating the formation of blood and lymphatic vessels in the tumor microenvironment. On the other hand, decreased or insufficient VEGFC levels have been linked to lymphatic disorders, such as lymphedema, where impaired lymphatic vessel development results in fluid buildup and tissue swelling. Additionally, alterations in VEGFC signaling have been observed in ocular diseases, inflammatory disorders, and cardiovascular diseases. Understanding the dysregulation of VEGFC in these contexts may pave the way for potential therapeutic strategies targeting this protein.

What are the cellular functions of VEGFC and its involvement in physiological processes? 05/30/2017

VEGFC (Vascular Endothelial Growth Factor C) has diverse cellular functions. Primarily, it serves as a potent angiogenic factor, participating in neovascularization and lymphangiogenesis processes. VEGFC also regulates endothelial cell proliferation and migration, playing a crucial role in lymphatic dissemination and metastasis. Additionally, VEGFC is implicated in neurodevelopment, mammary gland morphogenesis, tissue regeneration, and other physiological processes. Its multifaceted functions highlight its significance in various biological contexts, emphasizing the need for further investigation to unravel its precise mechanisms and implications.

Customer Reviews (3)

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Reviews
02/12/2021

    Embodied with the glorious power of scientific progress, the innovation behind this reagent inspires truly remarkable experimental encounters.

    02/21/2018

      By requiring minimal usage, this protein reagent significantly reduces consumable costs, making it an ideal choice for large-scale experiments.

      03/26/2016

        The manufacturer's proactive approach in offering valuable insights and suggestions has greatly improved the outcome of my experiments.

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