Recombinant Rat Vascular Endothelial Growth Factor C

• Cat.No.: Vegfc-616R
• Product Overview: Vegfc (Vascular Endothelial Growth Factor-C) is a 125 amino acid recombinant protein that lacks the N-terminal and C-terminal extensions and contains only the middle third VEGF homology domain.

Specification

• Cat. No.: Vegfc-616R
• Description: The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis, lymphangiogenesis and endothelial cell growth and survival, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-3 receptors.
• Biological Activity: Activity of Vegfc will be tested by the stimulation of VEGF-R3 phosphorylation in cells transfected with VEGF-R3. The expected ED₅₀ is > 200 ng/ml.
• Molecular Weight: 15.0 kDa
• Source: E. coli
• Species: Rat
• Form: Lyophilized without additives.
• Appearance: Lyophilized protein
• Endotoxin Level: <0.1 ng/μg
• Reconstitution: Centrifuge the vial prior to opening. Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/ml. The solution should be stored at -70°C.
• Purity: >90% by SDS-PAGE analyses.
• Storage: The lyophilized Vegfc is best-stored at -20°C. Reconstituted Vegfc should be stored in working aliquots at -70°C.
• Pathways: Bladder cancer; Cytokine-cytokine receptor interaction; Focal adhesion; Formation of Platelet plug; Hemostasis; Pancreatic cancer; Pathways in cancer; Platelet degranulation; Renal cell carcinoma; Response to elevated platelet cytosolic Ca2+; Signaling by VEGF; VEGF binds to VEGFR leading to receptor dimerization; VEGF ligand-receptor interactions; mTOR signaling pathway

Gene Information

• Gene Name: Vegfc vascular endothelial growth factor C [ Rattus norvegicus ]
• Official Symbol: Vegfc
• Synonyms: Vegfc; vascular endothelial growth factor C; VRP; VEGF-C; flt4-L; flt4 ligand; vascular endothelial growth factor-related protein
• Gene ID: 114111
• mRNA Refseq: NM_053653
• Protein Refseq: NP_446105
• UniProt ID: O35757
• Chromosome Location: 16p11
• Function: chemoattractant activity; growth factor activity; vascular endothelial growth factor receptor 3 binding