apoa1
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  • Official Full Name
  • apolipoprotein A-I
  • Background
  • This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008]
  • Synonyms
  • APOA1; apolipoprotein A-I; apo-AI; Sep2; Alp-1; Ltw-1; Sep-1; Sep-2; Apoa-1; Brp-14; Lvtw-1
Cat.#:APOA1-2478HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human APOA1 Protein, MYC/DDK-tagged
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Cat.#:APOA1-26120THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APOA1, Protein A-tagged
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Cat.#:APOA1-217HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human APOA1, C13&N15-labeled
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Cat.#:APOA1-33HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human APOA1, Fc tagged
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Cat.#:APOA1-34HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human APOA1 Protein, His-tagged
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Cat.#:APOA1-523HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APOA1, His tagged
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Cat.#:APOA1-689HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human APOA1 protein, GST-tagged
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Cat.#:APOA1-6916HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Apolipoprotein A-I, His-tagged
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Cat.#:APOA1-9747HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APOA1, GST-tagged
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Cat.#:Apoa1-38MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Apoa1, His-tagged
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Cat.#:Apoa1-6864MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Apoa1, Fc tagged
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Cat.#:Apoa1-7404MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Apoa1, His tagged
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Cat.#:APOA1-717RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat APOA1 Protein
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Cat.#:ApoA1-8446RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat ApoA1
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Cat.#:APOA1-303CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus APOA1 Protein, His-tagged
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Cat.#:APOA1-2726RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit APOA1 protein, His-tagged
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Cat.#:APOA1-7073CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken APOA1
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Cat.#:APOA1-2725PTag:His/GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig APOA1 protein, His & GST-tagged
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Cat.#:APOA1-698HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Apolipoprotein A-I
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Cat.#:APOA1-256HTag:
Source (Host):Human Plasma HDLSpecies:Human
Product nameNative Human APOA1 protein
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Cat.#:APOA1-26121THTag:
Source (Host):Species:Human
Product nameNative Human APOA1, Protein A-tagged
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Cat.#:APOA1-5301HTag:N/A
Source (Host):Human plasmaSpecies:Human
Product nameNative Human Apolipoprotein A-I
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Cat.#:APOA1-8034HTag:N/A
Source (Host):Human plasmaSpecies:Human
Product nameNative Human ApoLipoprotein
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Cat.#:ApoA-I-3554HTag:
Source (Host):Human plasmaSpecies:Human
Product nameNative Human ApoA-I
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Cat.#:APOA1-23DTag:
Source (Host):DogSpecies:Dog
Product nameNative Dog Apolipoprotein A1 (APOA1) Protein
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Cat.#:APOA1-3088HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human APOA1 cell lysate
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Cat.#:APOA1-1497MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse APOA1 cell lysate
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Cat.#:APOA1-2HTag:
Source (Host):Species:Human
Product nameHuman Apolipoprotein AI (Apo AI) Reference Standard
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Involved Pathway

APOA1 involved in several pathways and played different roles in them. We selected most pathways APOA1 participated on our site, such as PPAR signaling pathway, Fat digestion and absorption, Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOA1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PPAR signaling pathway
PPARG; PPARD; ACOX2; ACSL3B; ADIPOQB; ACSL3A; FABP7B; AQP7; GK2; ACSBG2
Fat digestion and absorption
PPAP2A; MTTP; LIPF; APOB; APOA1; DGAT1; ACAT2; PNLIPRP2; PPAP2B; PLA2G1B
Vitamin digestion and absorption
MMACHC; SLC19A2; SLC5A6; RBP2; SCARB1; SLC19A1; GIF; CUBN; BTD; APOA4
African trypanosomiasis
SELE; PLCB4; APOA1; FAS; VCAM1; FASLG; HBB-B1; TLR9; IFNG; TNF

Protein Function

APOA1 has several biochemical functions, for example, apolipoprotein A-I receptor binding, apolipoprotein receptor binding, beta-amyloid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APOA1 itself. We selected most functions APOA1 had, and list some proteins which have the same functions with APOA1. You can find most of the proteins on our site.
Function
Related Protein
Function apolipoprotein A-I receptor binding
Related Protein CDC42; APOA1; NR1H2
Function apolipoprotein receptor binding
Related Protein PCSK9; APOA2; APOA1
Function beta-amyloid binding
Related Protein GPRASP2; LDLRAP1; APOE; HBA-A2; ARMCX5-GPRASP2; IDE; HSD17B10; APBB3; CD74; APBB2
Function chemorepellent activity
Related Protein Sema3f; SEMA3BL; FLRT2; SEMA5A; SEMA3E; SEMA4D; NRG3; SEMA6E; SEMA3C; UBE4A
Function cholesterol binding
Related Protein SYP; SOAT1; NPC1; OSBPL8; OSBP2; OSBPL5; STARD6; APOEA; APOE; APOA2
Function contributes_to cholesterol transporter activity
Related Protein SFRP5; ABCG8; APOA1; APOA2; ABCG5
Function cholesterol transporter activity
Related Protein ABCG1; APOA4; APOA4B.2; APOEA; APOEB; APOA1A; APOA4A; ABCA13; ABCA1B; ABCA1
Function enzyme binding
Related Protein TTN; RPS2; KIAA1967; RCOR2; AXIN1; ITGB3; HLCS; HDAC2; HIST1H2AK; HIST1H2AL
Function high-density lipoprotein particle binding
Related Protein GPIHBP1; APOA1; APOA2; APOA1A; APOL2
Function high-density lipoprotein particle receptor binding
Related Protein APOC3; APOA1; APOA2
Function identical protein binding
Related Protein COL18A1; S100A1; CAD; KCNH2; CLDN1; TRIM21; MVK; CHMP4A; STAT6; CREBZF
Function lipase inhibitor activity
Related Protein APOA2; APOC1; APOC3; APOC2; FAF2; APOA1
Function phosphatidylcholine binding
Related Protein APOA5; CHMP2A; GPR119; NF1; RPE65; PCTP; ESYT2; SERPINA5; APOA1A; APOC1
Function phosphatidylcholine-sterol O-acyltransferase activator activity
Related Protein APOC1; APOEA; APOA4; APOA4B.1; APOA5; APOA4A; APOA1A; APOEB; APOA4B.2; APOA2
Function phospholipid binding
Related Protein TICAM2; PSD2; ESYT1; APOM; APOA5; LPAR3; PRKCI; APOEA; SGIP1; AMPH
Function phospholipid transporter activity
Related Protein ABCA13; ABCA4A; MTTP; ABCA1B; ABCA4; ABCA7; GLTPD1; OSBPL8; ATP8B5; OSBPL5
Function protein binding
Related Protein PIN1; FYCO1; ZNF580; NUP62CL; ZCCHC7; PEX16; CTDSP2; PSMD10; DYX1C1; GHRHR

Interacting Protein

APOA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOA1.
APP; HP

APOA1 Related Articles

Verhoeven, V; Van der Auwera, A; et al. Can red yeast rice and olive extract improve lipid profile and cardiovascular risk in metabolic syndrome?: a double blind, placebo controlled randomized trial. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 15:-(2015).
Liting, P; Guoping, L; et al. Apolipoprotein B/apolipoprotein A1 ratio and non-high-density lipoprotein cholesterol Predictive value for CHD severity and prognostic utility in CHD patients. HERZ 40:1-7(2015).