B2M
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Official Full Name
beta-2-microglobulin
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Overview
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia. -
Synonyms
B2M; beta-2-microglobulin; Beta-2-microglobulin; beta chain of MHC class I molecules; beta-2-microglobin;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Transfected Stable Cell Lines
- Bovine
- Chicken
- Cynomolgus
- Cynomolgus monkey
- Cynomolgus Monkey
- Cynomolgus/Rhesus macaque
- Dog
- Feline
- Golden hamster
- Human
- Mouse
- Pig
- Pongo pygmaeus
- Rat
- Rhesus monkey
- Sheep
- Zebrafish
- E.coli
- HEK293
- HEK293F
- HEK293T
- Human
- Human Cell
- Human Tissue
- Human Urine
- Human urine frompatients with tubular proteinuria
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- Fc
- Flag
- GST
- His
- Avi
- Myc
- Strep
- StrepII
- DDK
- N/A
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
B2M involved in several pathways and played different roles in them. We selected most pathways B2M participated on our site, such as Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with B2M were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing and presentation | HSPA4;HLA-DQB1;HLA-C;KLRC4;HLA-DRB5;HSPA2;NFYB;B2M;KIR3DL2 |
B2M has several biochemical functions, for example, glycoprotein binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by B2M itself. We selected most functions B2M had, and list some proteins which have the same functions with B2M. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glycoprotein binding | ERBB2;SHB;FOXRED2;HSPA5;HFE2;CALR;FBXO17;FYN;CANX |
| identical protein binding | PUF60;AIRE;IMPA1;PHC2;COL7A1;SERPINA1E;RB1;NISCH;ITGB3 |
| protein binding | RHOJ;ZNF143;RSL24D1;PA2G4;MTA1;SRGN;GSTZ1;CREM;SH2B3 |
B2M has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with B2M here. Most of them are supplied by our site. Hope this information will be useful for your research of B2M.
HFE; CD1A; CD1B; HLA-A
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewTo meet the needs of biological activity experiments
High purity, no impurities.
The expression level is high, which can meet the daily experimental needs.
Q&As (6)
Ask a questionThe normal reference range for B2M varies depending on age, gender, weight, individual differences, and other factors. In general, the normal reference range is between 0~3.0mg/L.
Causes of reduced B2M include liver and kidney failure, tuberculosis, HIV infection, rheumatoid arthritis, systemic lupus erythematosus and other diseases.
B2M plays an important role in the diagnosis and prognosis assessment of malignancies such as lymphoma and multiple myeloma. Elevated B2M levels can also indicate worsening or recurrence of certain autoimmune diseases, such as systemic lupus erythematosus.
It has a variety of physiological functions in the immune system, including inducing immune response, participating in lymphocyte proliferation and differentiation, regulating immune tolerance, and participating in tumor immune surveillance.
The levels can be affected by a variety of factors, such as cancer, inflammation, autoimmune diseases, infections, medications, etc.
This is associated with many diseases, including lymphoma, normal stress hydrocephalus, HIV infection, rheumatoid arthritis, nephrotic syndrome, cirrhosis, systemic lupus erythematosus, etc.
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