CCL2

  • Official Full Name

    chemokine (C-C motif) ligand 2

  • Overview

    This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]
  • Synonyms

    CCL2; chemokine (C-C motif) ligand 2; HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30; C-C motif chemokine 2; small-inducible cytokine A2; monocyte secretory protein JE; monocyte chemotactic protein 1; monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; monocyte chemotactic and activating factor; small inducible cytokine subfamily A (Cys-Cys), member 2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je);

  • Recombinant Proteins
  • GMP Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Bovine
  • Canine
  • Cattle
  • Cynomolgus Monkey
  • Dog
  • Equine
  • Guinea pig
  • Horse
  • Human
  • Mouse
  • Pig
  • Porcine
  • Rabbit
  • Rat
  • Rhesus macaque
  • Rhesus Macaque
  • Rhesus monkey
  • CHO
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Insect cells
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Biotin
  • C
  • His
  • DYKDDDDK
  • Fc
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • His|GST
  • His|T7
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Strep II
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CCL2-1680M Active Recombinant Mouse CCL2, HIgG1 Fc-tagged CHO Fc
Human CCL2-0621H Active Recombinant Human CCL2 Protein E.coli N/A
Human CCL2-108H Active Human CCL2 N/A
Human CCL2-381H Active Recombinant Human CCL2, MIgG2a Fc-tagged CHO Fc
Human CCL2-0621HG Active GMP Recombinant Human CCL2 protein HEK293 DNA sequence encoding Human MCP-1(NP_002973.1) was expressed with His tag at the C-terminal.
Human CCL2-11H Active Recombinant Human CCL2 Protein, His-tagged HEK293 His 24-99
Human CCL2-130H Recombinant Human CCL2, Fc-tagged CHO Fc
Human CCL2-0622H Recombinant Human CCL2 Protein, GST-Tagged Wheat Germ GST
Human CCL2-275H Recombinant Human CCL2, StrepII-tagged Human Cell Strep II 24-99, 76 a.a.
Human CCL2-281H Recombinant Human CCL2 protein E.coli N/A 76
Human CCL2-63H Recombinant Human Chemokine (C-C motif) Ligand 2, His-tagged E.coli His
Human CCL2-124H Recombinant Human Chemokine (C-C Motif) Ligand 2 Mammalian cells N/A
Human CCL2-189H Recombinant Human CCL2 protein(Gln24-Thr99), His-tagged Yeast C-His Gln24-Thr99
Human CCL2-1188H Recombinant Human Monocyte Chemoattractant Protein 1 E.coli N/A
Human CCL2-78H Recombinant Human CCL2 HEK293 N/A
Human CCL2-2890H Recombinant Human CCL2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CCL2-125H Human Monocyte Chemoattractant Protein-1(rDNA derived) Reference standard N/A
Human CCL2-500HB Recombinant Human CCL2 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Gln24-Thr99
Human CCL2-42H Recombinant Human CCL2 Protein E.coli 76 amino acid
Human CCL2-3792H Recombinant Human CCL2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CCL2-151H Recombinant Human CCL2 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human CCL2-2950HF Recombinant Full Length Human CCL2 Protein, GST-tagged In Vitro Cell Free System GST 99 amino acids
Human CCL2-500H Recombinant Human CCL2 protein, His-Avi-tagged HEK293 His-Avi Gln24-Thr99
Human CCL2-2650H Recombinant Human CCL2 protein, His&Myc-tagged E.coli His&Myc 24-99aa
Human CCL2-937HFL Recombinant Full Length Human CCL2 Protein, C-Flag-tagged Mammalian cells Flag
Human CCL2-14H Active Recombinant Human CCL2 Protein E.coli
Human CCL2-520H Recombinant Human CCL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CCL2-56H Recombinant Human CCL2 Protein, Biotin-tagged E.coli Biotin
Human CCL2-337C Active Recombinant Human CCL2 Protein (76 aa) E.coli 76
Human CCL2-520H-B Recombinant Human CCL2 Protein Pre-coupled Magnetic Beads HEK293
Human CCL2-016H Recombinant Human CCL2 Protein, Biotinylated 99
Human CCL2-080C Active Recombinant Human CCL2 Protein (76 aa) E.coli 76
Human CCL2-015H Recombinant Human CCL2 Protein 99
Human CCL2-267H Active Recombinant Human CCL2 Protein (Gln24-Thr99), N-His tagged, Animal-free, Carrier-free E.coli N-His Gln24-Thr99
Human CCL2-2649H Recombinant Human CCL2 protein, GST-tagged E.coli GST 24-99aa
Human CCL2-1170H Recombinant Human CCL2 Protein (Gln24-Thr99), N-His tagged E.coli N-His Gln24-Thr99
Mouse CCL2-1679M Active Recombinant Mouse CCL2, MIgG2a Fc-tagged CHO Fc
Mouse Ccl2-282M Active Recombinant Mouse Chemokine (C-C motif) Ligand 2 E.coli N/A
Mouse Ccl2-01M Active GMP Recombinant Mouse Ccl2 Protein, His-Tagged E.coli His
Mouse CCL2-559M Recombinant Mouse chemokine (C-C motif) ligand 2, His-tagged E.coli His
Mouse Ccl2-687M Recombinant Mouse Ccl2 protein, His-tagged E.coli His Gln24~Arg96 (Accession # P10148)
Mouse Ccl2-482M Recombinant Mouse Ccl2, His-tagged Insect Cell His Met1-Asn148
Mouse CCL2-001MCL Recombinant Mouse CCL2 cell lysate Insect Cell N/A
Mouse Ccl2-5742M Recombinant Mouse Ccl2 Protein (Gln24-Asn148), C-His tagged Mammalian cells C-His Gln24-Asn148
Mouse Ccl2-2030M Active Recombinant Mouse Ccl2 Protein HEK293 Gln24-Arg96
Mouse Ccl2-130M Active Recombinant Mouse Ccl2 Protein E.coli
Mouse Ccl2-482MB BiotinylatedRecombinant Mouse Ccl2 protein(Met1-Asn148), His-tagged Insect Cells C-His Met1-Asn148
Mouse Ccl2-75M Active Recombinant Mouse Ccl2 Protein (Gln24-Ala127), N-His tagged, Animal-free, Carrier-free E.coli N-His Gln24-Ala127
Mouse Ccl2-5430M Recombinant Mouse Ccl2 Protein (Gln24-Arg96) E.coli Tag Free Gln24-Arg96
Mouse Ccl2-2031M Recombinant Mouse Ccl2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Ccl2-7335M Recombinant Mouse Ccl2 Protein, His-tagged E.coli His 24-148
Mouse CCL2-15M Active Recombinant Mouse CCL2 Protein E.coli
Mouse Ccl2-173C Active Recombinant Mouse Ccl2 Protein (73 aa) HEK293 73
Rat Ccl2-469R Active Recombinant Rat Chemokine (C-C motif) Ligand 2 Mammalian cells N/A
Rat Ccl2-55R Recombinant Rat Chemokine (C-C Motif) Ligand 2 E.coli N/A
Rat CCL2-1211R Recombinant Rat CCL2 Protein Mammalian Cell His
Rat Ccl2-689R Recombinant Rat Ccl2 protein, His-tagged E.coli His Gln24~Asn148 (Accession# P14844)
Rat Ccl2-6380R Recombinant Rat Ccl2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Ccl2-02R Recombinant Rat Ccl2 protein, His-tagged Insect cells His
Rat Ccl2-1101R Recombinant Rat Ccl2 Protein, His-tagged HEK293F N-His Gln24-Asn148
Rat CCL2-869R-B Recombinant Rat CCL2 Protein Pre-coupled Magnetic Beads HEK293
Rat CCL2-2894R Recombinant Rat CCL2 Protein E.coli N/A
Rat Ccl2-6380R-B Recombinant Rat Ccl2 Protein Pre-coupled Magnetic Beads HEK293
Rat CCL2-16R Recombinant Rat CCL2 Protein E.coli
Rat Ccl2-172C Active Recombinant Rat Ccl2 Protein (125 aa) HEK293 125
Rat CCL2-869R Recombinant Rat CCL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus monkey CCL2-691R Recombinant Rhesus monkey CCL2 protein, His-tagged E.coli His Gln24~Pro99
Rhesus monkey CCL2-2145R Recombinant Rhesus monkey CCL2 Protein, His-tagged HEK293F N-His Gln24-Pro99
Rabbit Ccl2-283R Active Recombinant Rabbit Chemokine (C-C Motif) Ligand 2 E.coli N/A
Rabbit CCL2-690R Recombinant Rabbit CCL2 protein, His-tagged E.coli His Gln24~Leu125 (Accession# P28292)
Dog CCL2-683D Recombinant Dog CCL2 protein, His & GST-tagged E.coli His/GST Gln24~Pro101 (Accession # P52203)
Dog CCL2-2144D Recombinant Dog CCL2 Protein, His-tagged HEK293F N-His Gln24-Pro101
Bovine CCL2-131B Recombinant Bovine Chemokine (C-C motif) Ligand 2 Yeast N/A
Canine CCL2-406C Active Recombinant Canine Chemokine (C-C motif) Ligand 2 E.coli N/A
Canine CCL2-44C Recombinant Canine CCL2 (MCP-1) Yeast N/A
Cattle CCL2-1102C Recombinant Cattle CCL2 Protein, His-tagged E.coli N-His Gln24-Pro99
Cattle CCL2-2146C Recombinant Cattle CCL2 Protein, His-tagged HEK293F N-His Gln24-Pro99
Cynomolgus Monkey CCL2-372C Recombinant Cynomolgus CCL2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CCL2-01C Recombinant Cynomolgus Monkey CCL2 Protein Yeast
Cynomolgus Monkey CCL2-120C Recombinant Cynomolgus Monkey CCL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CCL2-120C-B Recombinant Cynomolgus Monkey CCL2 Protein Pre-coupled Magnetic Beads HEK293
Equine CCL2-21E Recombinant Equine CCL2 Yeast N/A
Equine CCL2-139E Recombinant Equine Chemokine (C-C motif) Ligand 2 Yeast N/A
Guinea pig Ccl2-685G Recombinant Guinea pig Ccl2 protein, His & T7-tagged E.coli His/T7 Gln24~Ser120 (Accession # Q08782)
Horse CCL2-684H Recombinant Horse CCL2 protein, His & T7-tagged E.coli His/T7 Met1~Pro99 (Accession # Q9TTQ3)
Horse CCL2-1104H Recombinant Horse CCL2 Protein, His-tagged E.coli N-His Gln24-Pro99
Porcine CCL2-01P GMP Recombinant Porcine CCL2 Protein, His-Tagged E.coli His
Rhesus macaque CCL2-185R Recombinant Rhesus macaque CCL2 protein, GST-tagged E.coli GST
Rhesus Macaque CCL2-683R Recombinant Rhesus monkey CCL2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CCL2-511R-B Recombinant Rhesus Macaque CCL2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CCL2-511R Recombinant Rhesus Macaque CCL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Pig CCL2-688P Recombinant Pig CCL2 protein, His & GST-tagged E.coli His/GST Gln24~Pro99 (Accession # P42831)
Pig CCL2-144S Recombinant Swine Chemokine (C-C motif) Ligand 2 Yeast N/A
Pig CCL2-2147P Recombinant Pig CCL2 Protein, His-tagged HEK293F N-His Gln24-Pro99
Pig CCL2-1103P Recombinant Pig CCL2 Protein, His-tagged E.coli N-His Gln24-Pro99
Pig CCL2-209P Recombinant Pig CCL2 Protein (Gln24-Pro99), N-His tagged, Animal-free, Carrier-free E.coli N-His Gln24-Pro99
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CCL2 involved in several pathways and played different roles in them. We selected most pathways CCL2 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIFNGR2;IL10RB;CCR6;CCL2;IL1R2;TGFB1;CSF1;CXCR4;IRX1
Chemokine signaling pathwayCCL19;GNG4;PF4V1;CXCR6;CXCL11;GM10591;PIK3R3;CCL24;MAPK3
NOD-like receptor signaling pathwayBIRC3;HSP90AA1;NFKBIAB;PSTPIP1;CASP1;HSP90B1;NAIP7;HSP90AB1;CXCL2
TNF signaling pathwayPIK3R5;MAPK9;CASP10;VEGFC;TRADD;AKT2;TRAF1;TRAF5;CCL20
Chagas disease (American trypanosomiasis)MAPK11;IFNGR2;TGFBR1;PIK3R3;TNF;FOS;FADD;PPP2R1A;IL12A
MalariaCD81;DARC;GYPA;ITGB2L;TLR9;IL18;GYPB;TGFB3;HBA-A2
Influenza ALOC780933;IFNA5;HLA-DPA1;DNAJB1;EIF2AK2;HSPA1L;IKBKB;HLA-DQA1;IFNA8
Herpes simplex infectionPTPN11B;PER1A;HLA-DPA1;HLA-DPB1;IRF3;TNFRSF14;HNRNPK;IL12B;HLA-DQA2
Rheumatoid arthritisATP6V0D1;Il23a;VEGFA;TLR2;ATP6V1A;IL23;ATP6V1B2;HLA-DRA;CCL5

CCL2 has several biochemical functions, for example, CCR2 chemokine receptor binding, chemokine activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL2 itself. We selected most functions CCL2 had, and list some proteins which have the same functions with CCL2. You can find most of the proteins on our site.

Function Related Protein
CCR2 chemokine receptor bindingCCL7;Ccl12;CCL2
chemokine activityCXCL11.8;CCL20A.3;CCL34B.9;CCL34B.4;CXCL2;CCL13;CXCL18B;CCL25B;CCL35.2
heparin bindingLPA;CLEC3B;C6orf25;PF4;NDNF;SMOC2;MMP7;ABI3BP;COMP
protein kinase activityKDRL;PRKCDA;GM711;PKDCC;GSK3AB;MAP4K3;BSK146;CDC42BPB;NRBP1
receptor bindingTRIM24;NCR3;TYROBP;HFE;FGF20B;MIF;LEPROT;GLA;PVRL1

CCL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL2.

GAMMAHV.M3

Gene Family

Chemokines Cytokines

Research Area

Related articles

Driss, V; Quesnel, B; et al. Monocyte chemoattractant protein 1 (MCP-1/CCL2) contributes to thymus atrophy in acute myeloid leukemia. EUROPEAN JOURNAL OF IMMUNOLOGY 45:396-406(2015).
Martirosyan, A; Petrek, M; et al. Differential Regulation of Proinflammatory Mediators following LPS- and ATP-Induced Activation of Monocytes from Patients with Antiphospholipid Syndrome. BIOMED RESEARCH INTERNATIONAL :-(2015).
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