Species : |
Mouse |
Source : |
HEK293 |
Protein Length : |
Gln24-Arg96 |
Description : |
This gene is one of several cytokine genes clustered on chromosome 11. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and memory T cells but not for neutrophils. The human ortholog has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis, and atherosclerosis. |
Bio-activity : |
The ED50 is 8 -15 ng/mL, corresponding to a specific activity of 0.6 - 1.25 x 10^5 units/mg, determined by the dose dependent chemoattraction of THP-1 cells. |
Molecular Mass : |
8.5 kDa |
Endotoxin : |
Less than 0.01 ng/μg protein as determined by the LAL method |
Purity : |
> 98%, as determined by Coomassie stained SDS-PAGE. |
Stability : |
Unopened vial can be stored between 2 and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles. |
Storage : |
Store at -80 centigrade. |
Concentration : |
Protein formulated and vialed at >50 μg/mL in specified buffer |
Storage Buffer : |
1 x PBS |