CCL2-1680M
Optional Service: Optional requirements on this protein
Product Overview :
The extracellular domain of human CCL2 (NP_002973.1) (Gln24-Thr99) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell.
Description :
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamilyof secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided intofour subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokineis a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displayschemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicatedin the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis andatherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
Source :
CHO cells
Species :
Human
Tag :
HIgG1 Fc-tagged
Form :
Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity :
Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR2A.
Molecular Mass :
35 KDa (monomer)
AA Sequence :
Gln24-Thr99
Endotoxin :
<0.06 eu/μg as determined by lal test.>
Purity :
>98%, by SDS-PAGE under reducing conditions.
Stability :
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.