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GMP Recombinant Porcine CCL2 Protein, His-Tagged
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Cat.No. : | CCL2-01P Optional Service: Optional requirements on this protein |
Product Overview : | GMP Recombinant Porcine CCL2 Protein, His-Tagged was expressed in Escherichia coli cell-derived in an animal component free process under cGMP guidelines. |
Description : | CCL2, also known as MCP-1, is belonging to the CC ß chemokine family. CCL2 can be identified in endothelial cells, smooth muscle cells and monocytes as the results of reaction to several atherogenic stimulants, such as CD40 ligand, (IL-1β) and oxidized low density lipoprotein , interleukin-1βplatelet derived growth factor (PDGF). Recent study shows that in vivo MCP1 have several critical roles in atherosclerosis. Additionally, MCP-1 has been proved involving in monocytic infiltration of tissues during several inflammatory diseases, and has been implicated in macrophage-mediated tumor growth inhibition in mice. In addition, CCL2 has been shown to have direct effects on tumor cells in an autocrine and paracrine fashion in multiple cancers, including sarcoma, lung, cervix, ovary, breast, and prostate. |
Source : | Escherichia coli |
Species : | Porcine |
Tag : | His |
Form : | Lyophilized |
AA Sequence : | QPDAINSPVT CCYTLTSKKI SMQRLMSYRR VTSSKCPKEA VIFKTIAGKE ICAEPKQKWV QDSISHLDKK NQTPKP with polyhistidine tag at the N-terminus |
Endotoxin : | <0.1 EU per 1 μg of the protein by the LAL method. |
Purity : | >98% as determined by SDS-PAGE. Ni-NTA chromatography |
Notes : | Please use within one month after protein reconstitution. |
Storage : | Lyophilized protein should be stored at -20°C. Upon reconstitution, protein aliquots should be stored at -20°C or -80°C. |
Storage Buffer : | The protein was lyophilized from a solution containing 1X PBS, pH 7.4. |
Reconstitution : | It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved. |
Figure : |
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Gene Name : | CCL2 chemokine (C-C motif) ligand 2 [ Sus scrofa (pig) ] |
Official Symbol : | CCL2 |
Synonyms : | MCP-1 |
Gene ID : | 397422 |
mRNA Refseq : | NM_214214.1 |
Protein Refseq : | NP_999379.1 |
UniProt ID : | P42831 |
◆ Recombinant Protein
CCL2-01C | Recombinant Cynomolgus Monkey CCL2 Protein | +Inquiry |
Ccl2-173C | Recombinant Mouse Ccl2 Protein (73 aa) | +Inquiry |
CCL2-080C | Recombinant Human CCL2 Protein (76 aa) | +Inquiry |
CCL2-16R | Recombinant Rat CCL2 Protein | +Inquiry |
CCL2-337C | Recombinant Human CCL2 Protein (76 aa) | +Inquiry |
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◆ Lysates
CCL2-001MCL | Recombinant Mouse CCL2 cell lysate | +Inquiry |
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CCL1CCL11Ccl12CCL13CCL14CCL15CCL16CCL17CCL18CCL19CCL2CCL20CCL21Ccl21cCCL22CCL23CCL24CCL25CCL26CCL27Ccl27aCCL28CCL3CCL3L1Ccl4CCL5Ccl6CCL7CCL8Ccl9CCL4L2Ccl21aCCL4L1CCL3L3Ccl21bCcl27b
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