CD22

  • Official Full Name

    CD22 molecule

  • Overview

    CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins.[1] It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
  • Synonyms

    SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2; BLCAM; Leu14; Siglec-2; Bectumomab; LymphoScan; 158318-63-9; Epratuzumab; 205923-57-5; Moxetumomab pasudotox; 1020748-57-5; Inotuzumab ozogamicin; 635715-01-4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chromatography Reagents
  • GMP Proteins
  • Canine
  • Human
  • Monkey
  • Mouse
  • Rat
  • Rhesus
  • Rhesus macaque
  • Rhesus Macaque
  • Zebrafish
  • CHO
  • CHO cells
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human Cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • NS0
  • Avi|Fc
  • C
  • Fc
  • hFc
  • 6×His
  • His
  • Myc
  • DDK
  • Fc Chimera
  • Avi
  • hFc, Avi
  • His (Fc)
  • LIgG2b Fc
  • MYC
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD22-482H Active Recombinant Human CD22, Fc Chimera Mammalian cells Fc Chimera
Human CD22-559H Active Recombinant Human CD22, His-tagged, Biotinylated Human Cell His
Human CD22-560H Active Recombinant Human CD22, Fc-tagged, Biotinylated Human Cell Fc
Human CD22-561H Active Recombinant Human CD22, Fc-tagged Human Cell Fc
Human CD22-335H Active Recombinant Human CD22 Protein (Asp 20 - Arg 687), His-tagged, FITC-Labeled HEK293 His
Human CD22-3947HAF488 Active Recombinant Human CD22 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Human CD22-051H Active Recombinant Human CD22 protein, His/Avi-tagged, Biotinylated CHO cells His/Avi
Human CD22-055H Active Recombinant Human CD22 protein, Fc/Avi-tagged, Biotinylated CHO cells Fc/Avi
Human CD22-3947HF Active Recombinant Human CD22 Protein, His-tagged, FITC conjugated HEK293 His
Human CD22-482HAF488 Active Recombinant Human CD22 Protein, Fc-tagged, Alexa Fluor 488 conjugated Mammalian cells Fc
Human CD22-561HF Active Recombinant Human CD22 Protein, Fc-tagged, FITC conjugated HEK293 Fc
Human CD22-561HAF488 Active Recombinant Human CD22 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Human CD22-3947HAF555 Active Recombinant Human CD22 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Human CD22-482HAF555 Active Recombinant Human CD22 Protein, Fc-tagged, Alexa Fluor 555 conjugated Mammalian cells Fc
Human CD22-561HAF555 Active Recombinant Human CD22 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Human CD22-3947HAF647 Active Recombinant Human CD22 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Human CD22-482HAF647 Active Recombinant Human CD22 Protein, Fc-tagged, Alexa Fluor 647 conjugated Mammalian cells Fc
Human CD22-561HAF647 Active Recombinant Human CD22 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Human CD22-482HF Active Recombinant Human CD22 Protein, Fc-tagged, FITC conjugated Mammalian cells Fc
Human CD22-3946H Active Recombinant Human CD22 protein, His-tagged HEK293 His
Human CD22-246H Recombinant Human CD22, StrepII-tagged Human Cell Strep II
Human CD22-562H Active Recombinant Human CD22 protein, Fc-tagged HEK293 Fc
Human CD22-10926H Recombinant Human CD22, His-tagged E.coli His
Human CD22-960H Recombinant Human CD22 Molecule, Extracellular Domain CHO N/A
Human CD22-27297TH Recombinant Human CD22 CHO N/A
Human CD22-1956HCL Recombinant Human CD22 cell lysate Human Cell N/A
Human CD22-01H Recombinant Human CD22 Protein, hFc, Avi tagged, Biotinylated Human Cell hFc, Avi
Human CD22-562HAF647 Recombinant Human CD22 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Human CD22-562HP Recombinant Human CD22 protein, Fc-tagged, R-PE labeled HEK293 Fc
Human CD22-533H Recombinant Human CD22 Protein (Met1-Arg687) (ECD) HEK293 N/A
Human CD22-15H-B Recombinant Human CD22 Protein Pre-coupled Magnetic Beads HEK293
Human CD22-663H Recombinant Human CD22 Protein, His-tagged E.coli N-His
Human CD22-3947HA Recombinant Human CD22 protein, His-tagged, APC labeled HEK293 His
Human CD22-181H Recombinant Human CD22 Protein, C-His-tagged E.coli C-His
Human CD22-0663H Recombinant Human CD22 protein, His-tagged, Alexa Fluor 555-Labeled HEK293 His
Human CD22-15H Recombinant Human CD22 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CD22-334H Active Recombinant Human CD22 Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
Human CD22-441H Recombinant Human CD22 Protein, His-tagged HEK293 His
Human CD22-0664H Active Recombinant Human CD22 protein, Fc-tagged, FITC-Labeled HEK293 Fc
Human CD22-0662H Recombinant Human CD22 protein, His-tagged, Alexa Fluor 488-Labeled HEK293 His
Human CD22-273HB Active Recombinant Human CD22 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
Human CD22-442H Recombinant Human CD22 Protein, His-tagged HEK293 His
Human CD22-0666H Active Recombinant Human CD22 protein, His-tagged, FITC-Labeled HEK293 His
Human CD22-4807H Recombinant Human CD22 protein, His-tagged, PE-Labeled HEK293 His
Human CD22-158H Recombinant Human CD22 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human CD22-1411H Recombinant Human CD22 Protein (Trp176-Ala330), N-His tagged E.coli N-His
Human CD22-753M CD22 protein-coupled magnetic MicroBeads
Human CD22-5322H Recombinant Human CD22 Protein (Met1-Arg687), C-His tagged Mammalian cells C-His
Human CD22-273H Recombinant Human CD22 protein, His-Avi-tagged HEK293 His-Avi
Human CD22-0945M Active CD22 protein-coupled magnetic Beads HEK293
Human CD22-482HP Recombinant Human CD22 protein, Fc-tagged, R-PE labeled Mammalian cells Fc
Human CD22-562HA Recombinant Human CD22 protein, Fc-tagged, APC labeled HEK293 Fc
Human CD22-3946HB Recombinant Human CD22 protein, His-tagged, Biotinylated HEK293 His
Human CD22-23H Active Recombinant Human CD22 Protein, Fc-tagged, Atto 488 conjugated NS0 Fc
Human CD22-561HP Recombinant Human CD22 protein, Fc-tagged, R-PE labeled HEK293 Fc
Human CD22-562HAF488 Recombinant Human CD22 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Human CD22-562HF Recombinant Human CD22 Protein, Fc-tagged, FITC conjugated HEK293 Fc
Human CD22-333H Active Recombinant Human CD22 Protein, LIgG2b Fc-tagged, low endotoxin HEK293 LIgG2b Fc
Human CD22-482HA Recombinant Human CD22 protein, Fc-tagged, APC labeled Mammalian cells Fc
Human CD22-532H Recombinant Human CD22 Protein (Trp176-Arg687), His-tagged, Biotinylated Insect Cell His
Human CD22-562HAF555 Recombinant Human CD22 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Human CD22-373HG Active GMP Recombinant Human CD22 protein HEK293
Human CD22-561HA Recombinant Human CD22 protein, Fc-tagged, APC labeled HEK293 Fc
Human CD22-3947HB Recombinant Human CD22 protein, His-tagged, Biotinylated HEK293 His
Human CD22-3947H Active Recombinant Human CD22 Protein, His-tagged HEK293 His
Human CD22-3947HP Recombinant Human CD22 protein, His-tagged, R-PE labeled HEK293 His
Human CD22-596H Active Recombinant Human CD22 Protein, hFc-tagged HEK293 hFc
Human CD22-374HG Active GMP Recombinant Human CD22 protein, Fc-tagged HEK293 Fc
Human CD22-496H Recombinant Human CD22 Protein (Asp20-Arg687), C-hFc and 6×His-tagged HEK293 C-hFc and 6×His
Human CD22-543H Recombinant Human CD22 Protein, His-tagged Human Cells His
Human CD22-5323H Recombinant Human CD22 Protein (Met1-Arg687), C-Fc tagged Mammalian cells C-Fc
Human CD22-24H Active Recombinant Human CD22 Protein, Fc-tagged, Atto 647N conjugated NS0 Fc
Mouse Cd22-535M Recombinant Mouse Cd22, His-tagged HEK293 His
Mouse CD22-179M Recombinant Mouse Cd22, Fc tagged Human Cell His
Mouse CD22-001MCL Recombinant Mouse CD22 cell lysate Human Cell N/A
Mouse Cd22-8321M Recombinant Mouse Cd22 protein, hFc-tagged HEK293 hFc
Mouse Cd22-831M Recombinant Mouse Cd22 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse CD22-336M Recombinant Mouse CD22 protein, His-tagged HEK293 His
Mouse CD22-694M CD22 protein-coupled magnetic MicroBeads
Mouse Cd22-535MB Recombinant Mouse Cd22 Protein (Met1-Arg708), His tagged, Biotinylated Human Cell His
Rat Cd22-1153R Recombinant Rat Cd22 Protein, Fc-tagged HEK293 Fc
Rat Cd22-1154R Recombinant Rat Cd22 Protein, His-tagged HEK293 His
Rat Cd22-1153RAF488 Recombinant Rat Cd22 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Rat Cd22-1153RAF555 Recombinant Rat Cd22 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Rat Cd22-1153RP Recombinant Rat Cd22 protein, Fc-tagged, R-PE labeled HEK293 Fc
Rat Cd22-1153RAF647 Recombinant Rat Cd22 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Rat Cd22-1153RF Recombinant Rat Cd22 Protein, Fc-tagged, FITC conjugated HEK293 Fc
Rat Cd22-1153RA Recombinant Rat Cd22 protein, Fc-tagged, APC labeled HEK293 Fc
Monkey CD22-8854CAF555 Recombinant Monkey CD22 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Monkey CD22-8854CAF488 Recombinant Monkey CD22 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Monkey CD22-8854CF Recombinant Monkey CD22 Protein, Fc-tagged, FITC conjugated HEK293 Fc
Monkey CD22-8854CAF647 Recombinant Monkey CD22 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Canine CD22-0665C Recombinant Canine CD22 protein, His-tagged HEK293 His
Rhesus CD22-8854CP Recombinant Rhesus CD22 protein, Fc-tagged, R-PE labeled HEK293 Fc
Rhesus CD22-8854CA Recombinant Rhesus CD22 protein, Fc-tagged, APC labeled HEK293 Fc
Rhesus macaque CD22-1212R Recombinant Rhesus macaque CD22 protein, His-tagged HEK293 His
Rhesus Macaque CD22-8854C Recombinant Rhesus CD22 protein, Fc-tagged HEK293 Fc
Zebrafish CD22-5443Z Recombinant Zebrafish CD22 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CD22 Related Articles
  • CD22 Related Research Area

CD22 involved in several pathways and played different roles in them. We selected most pathways CD22 participated on our site, such as Cell adhesion molecules (CAMs), Hematopoietic cell lineage, B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)CLDN8;NEO1;VCAM1;CLDN11;CLDN15;ICAM1;VTCN1;CD22;PTPRF
Hematopoietic cell lineageHLA-DRB3;CD8B;CD1E;ITGA5;IL3;GM-CSF;THPO;IL9R;TNF
B cell receptor signaling pathwayMAPK3;DOK1B;FCGR2B;BLK;PIK3R1;NFKB1;CD22;NFKBIA;GRB2

CD22 has several biochemical functions, for example, carbohydrate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD22 itself. We selected most functions CD22 had, and list some proteins which have the same functions with CD22. You can find most of the proteins on our site.

Function Related Protein
carbohydrate bindingASGR1;LGALS14;HBL3;CALR;GFPT1;ZG16B;GALNT10;LGALSL;PKD1L3
protein bindingBTN2A2;HPCAL4;FAM120B;KIAA0649;AKAP9;ARAF;LRP1;SRSF7;AKAP5

CD22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD22 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD22.

SYK; LYN; PLCG1; PTPN6; PTPRC; cpxA; PIK3R1

Lv, W; Duan, QL; et al. Expression of B-cell-associated genes in peripheral blood mononuclear cells of patients with symptomatic pulmonary embolism. MOLECULAR MEDICINE REPORTS 11:2299-2305(2015).
Jabbour, E; O'Brien, S; et al. Prognostic factors for outcome in patients with refractory and relapsed acute lymphocytic leukemia treated with inotuzumab ozogamicin, a CD22 monoclonal antibody. AMERICAN JOURNAL OF HEMATOLOGY 90:193-196(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does CD22-targeted immunotherapy differ from traditional chemotherapy? 02/05/2023

CD22-targeted immunotherapy is more targeted, specifically attacking cancer cells, whereas chemotherapy affects both healthy and cancerous cells.

Can CD22-targeted therapies be used in combination with other cancer treatments? 01/09/2023

Yes, CD22-targeted therapies are often used in combination with chemotherapy or other immunotherapies for enhanced efficacy.

What other diseases involve CD22 as a therapeutic target? 10/08/2020

CD22-targeted therapies are being explored for autoimmune diseases like rheumatoid arthritis and systemic lupus erythematosus.

Are there any clinical applications of CD22 protein in cancer therapy? 01/11/2019

Yes, CD22 is targeted in immunotherapy for B cell malignancies like acute lymphoblastic leukemia (ALL).

What role does CD22 play in B cell function? 05/13/2018

CD22 acts as an inhibitory receptor, regulating B cell activation and signaling.

Customer Reviews (3)

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Reviews
01/15/2021

    The CD22 protein offers numerous advantages in trials and research studies, making it an excellent choice for scientists in need of reliable and high-quality experimental materials.

    06/15/2017

      Its unique properties make CD22 an invaluable tool for investigating cellular signaling pathways, protein-protein interactions, and membrane dynamics.

      02/17/2016

        With the CD22 protein and its accompanying technical assistance, I am confident that I can achieve successful outcomes for my research endeavors.

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