Active Recombinant Human CD22 Protein, His-tagged, Alexa Fluor 488 conjugated
| Cat.No. : | CD22-3947HAF488 |
| Product Overview : | Alexa Fluor 488 conjugated recombinant human CD22 protein (176-687aa) was expressed in HEK293 cells with His tag at C terminal. |
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| Description : | B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2/CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2/CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. |
| Source : | HEK293 |
| Species : | Human |
| Tag : | His |
| Form : | Lyophilized |
| Bio-activity : | Immobilized Human CD22 Protein, His-tagged at 2 μg/mL (100 μL/well) can bind Anti-Human CD22 MAb, Human IgG1 with a linear range of 0.1-2 ng/mL (QC tested). |
| Molecular Mass : | The protein has a calculated MW of 57.8 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin : | < 1.0 EU/ μg by the LAL method. |
| Purity : | > 95 % as determined by SDS-PAGE |
| Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 488 via amines Excitation Wavelength: 488 nm Emission Wavelength: 515-545 nm |
| Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. |
| Storage Buffer : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. |
| Gene Name : | CD22 CD22 molecule [ Homo sapiens ] |
| Official Symbol : | CD22 |
| Synonyms : | CD22; CD22 molecule; CD22 antigen; B-cell receptor CD22; sialic acid binding Ig like lectin 2; SIGLEC 2; SIGLEC2; BL-CAM; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2; SIGLEC-2; FLJ22814; MGC130020 |
| Gene ID : | 933 |
| mRNA Refseq : | NM_001185099 |
| Protein Refseq : | NP_001172028 |
| MIM : | 107266 |
| UniProt ID : | P20273 |
Products Types
| ◆ Lysates | ||
| CD22-001MCL | Recombinant Mouse CD22 cell lysate | +Inquiry |
| CD22-1956HCL | Recombinant Human CD22 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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