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Official Full Name CD8a molecule
Background The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms CD8A; CD8a molecule; CD8, CD8 antigen, alpha polypeptide (p32) , T cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 alpha chain; T8 T-cell antigen; T cell co-receptor; OKT8 T-cell antigen; T-cell antigen Leu2; Leu2 T-lymphocyte
    • Species :
    • Bovine
    • Chicken
    • Cynomolgus
    • Ferret
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Human cells
    • Mammalian Cell
    • Mouse
    • Wheat Germ
    • Yeast
    • Tag :
    • Fc
    • His
    • GST
    • Flag
    • SUMO
    • HlgG1 Fc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CD8A-131H Recombinant Human CD8A Protein, DYKDDDDK-tagged Human cells DYKDDDDK
    Human CD8A-132H Recombinant Human CD8A Protein, His-tagged Human Cells His
    Human CD8A-133H Recombinant Human CD8A Protein, His-tagged Human cells His
    Human CABTT-003MH Mouse Anti-Human CD8A Monoclonal Antibody Mouse N/A
    Human CD8A&CD8B-211H Recombinant Human CD8A&CD8B protein, His/FLAG-tagged HEK293 His/Flag
    Human CD8A-0878H Recombinant Human CD8A Protein, GST-Tagged Wheat Germ GST
    Human CD8A--1097H Recombinant Human CD8A Protein (Met1-Asp182), HlgG1 Fc-tagged HEK293 HlgG1 Fc
    Human CD8A-10982H Recombinant Human CD8A, GST-tagged E.coli GST
    Human CD8A-1158H Recombinant Human CD8a Protein, His-tagged Yeast His
    Human CD8A-2493HCL Recombinant Human CD8A cell lysate Human Cell N/A
    Human CD8A-266H Recombinant Human CD8A Protein, His-tagged HEK293 His
    Human CD8A-272H Recombinant Human CD8A protein, His-tagged E.coli His
    Human CD8A-273H Recombinant Human CD8A protein, His-tagged E.coli His
    Human CD8A-274H Recombinant Human CD8A protein, His-tagged E.coli His
    Human CD8A-27890TH Recombinant Human CD8A Wheat Germ N/A
    Human CD8A-3196H Recombinant Human CD8a Molecule, His-tagged, active HEK293 His
    Mouse Cd8a-1502M Recombinant Mouse Cd8a protein, His & GST-tagged E.coli His/GST
    Mouse Cd8a-152MG GMP Recombinant Mouse Cd8a protein, His-tagged HEK293 His
    Mouse Cd8a-2283M Recombinant Mouse Cd8a, His tagged Human Cell His
    Mouse CD8A-2514MCL Recombinant Mouse CD8A cell lysate Human Cell N/A
    Mouse CD8A-822M Recombinant Mouse CD8A Protein (Met1-Tyr196), HlgG1 Fc-tagged HEK293 HlgG1 Fc
    Mouse CD8A-823M Recombinant Mouse CD8A Protein (Met1-Tyr196), His-tagged, Biotinylated HEK293 His
    Rat CD8A-1264R Recombinant Rat CD8A Protein Mammalian Cell His
    Rat Cd8a-1503R Recombinant Rat Cd8a protein, His-tagged E.coli His
    Rat Cd8a-28R Recombinant Rat Cd8a, Fc tagged Human Cell Fc/His
    Rat CD8A-827RCL Recombinant Rat CD8A cell lysate Human Cell N/A
    Cynomolgus CD8A--1098C Recombinant Cynomolgus CD8A Protein (Met42-Asp223), HlgG1 Fc-tagged HEK293 HlgG1 Fc
    Bovine CD8A-401B Recombinant Bovine CD8A Protein (26-189 aa), His-SUMO-tagged E.coli His/SUMO
    Chicken CD8A-3508C Recombinant Chicken CD8A Mammalian Cell His
    Zebrafish CD8A-3719Z Recombinant Zebrafish CD8A Mammalian Cell His
    Ferret CD8A-1021F Recombinant Ferret CD8A Protein, His-tagged HEK293 His
    Ferret CD8A-1872FCL Recombinant Ferret CD8A cell lysate Human Cell N/A

    cd8a involved in several pathways and played different roles in them. We selected most pathways cd8a participated on our site, such as Cell adhesion molecules (CAMs), Antigen processing and presentation, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with cd8a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell adhesion molecules (CAMs) HLA-DRB3; JAM2; CLDN6; ITGA9; LRRC4; MHC2DEB; CNTN2; MHC1UXA2; MADCAM1; CLDN5B
    Antigen processing and presentation KIR3DL1; HSPA4; HSPA8; KLRC2; HSP90AA1; HLA-DPB1; B2M; LGMN; KIR2DL1; HLA-DMB
    Hematopoietic cell lineage IL1R1; GYPA; CR2; CD1C; IL1A; IL11RA2; CD3D; CD8A; CD59A; IL5RA
    T cell receptor signaling pathway PPP3CB; VAV1; NFKB1; CABIN1; PPP3R1; TNF; CBLC; PTPRC; ICOS; NFKBIA
    nodeficiency CD8A; ICOS; IKBKG; TAP1; CD3E; BLNK; UNG; RFXAP; ZAP70; IL2RG

    cd8a has several biochemical functions, for example, MHC class I protein binding, coreceptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cd8a itself. We selected most functions cd8a had, and list some proteins which have the same functions with cd8a. You can find most of the proteins on our site.

    Function Related Protein
    MHC class I protein binding TUBB; CD244; Pilrb1; TAPBP; DERL1; ATP5A1; PILRB2; PILRB; LILRB1; BCAP31
    coreceptor activity CD86; CCR8; CD8A; ACVR2A; IGSF1; RAMP2; ACKR3B; CXCR7B; TMIGD2; HFE2
    protein binding DCAF7; GABBR2; TRIM21; MUS81; IGBP1; CHPF; VHL; EYA4; DHX9; FIG4
    protein homodimerization activity ADSSL1; CAMK2A; GPD1B; HEYL; SMAGP; TIMELESS; PDXK; PVRL3B; CHMP4C; CORO1A
    protein kinase binding SYK; DLG1; KCNH1; LSM2; CCNL1B; PRKAG3; HNRNPA0; NPR1; CCND2; RICTOR

    cd8a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cd8a here. Most of them are supplied by our site. Hope this information will be useful for your research of cd8a.

    CDK1; q7ckm5_yerpe; y2573_yerpe; CACYBP

    Chen, SH; Lee, LF; et al. Combination of 4-1BB Agonist and PD-1 Antagonist Promotes Antitumor Effector/Memory CD8 T Cells in a Poorly Immunogenic Tumor Model. CANCER IMMUNOLOGY RESEARCH 3:149-160(2015).
    Furugaki, K; Cui, L; et al. Intraperitoneal Administration of a Tumor-Associated Antigen SART3, CD40L, and GM-CSF Gene-Loaded Polyplex Micelle Elicits a Vaccine Effect in Mouse Tumor Models. PLOS ONE 9:-(2014).

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