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CD8A

  • Official Full Name

    CD8a molecule

  • Overview

    The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    CD8A; CD8a molecule; CD8, CD8 antigen, alpha polypeptide (p32) , T cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 alpha chain; T8 T-cell antigen; T cell co-receptor; OKT8 T-cell antigen; T-cell antigen Leu2; Leu2 T-lymphocyte;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • GMP Proteins
  • Chromatography Reagents
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Ctenopharyngodon idella
  • Cynomolgus
  • Felis catus (Cat) (Felis silvestris catus)
  • Ferret
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Pongo pygmaeus (Bornean orangutan)
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293F
  • Human Cell
  • Human cells
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Wheat Germ
  • Yeast
  • C
  • His
  • Twin
  • Strep
  • DYKDDDDK
  • Fc|His
  • GST
  • hFc
  • His (Fc)
  • Avi
  • His|Flag
  • His|GST
  • His|SUMO
  • SUMO
  • HlgG1 Fc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD8A&CD8B-211H Active Recombinant Human CD8A&CD8B protein, His/FLAG-tagged HEK293 His/Flag
Human CD8A-266H Active Recombinant Human CD8A protein, His-tagged CHO His Met1-Asp182
Human CD8A-3196H Active Recombinant Human CD8A protein, His-tagged HEK293 His Ser22-Asp182
Human CD8A-0878H Recombinant Human CD8A Protein, GST-Tagged Wheat Germ GST
Human CD8A-272H Recombinant Human CD8A protein, His-tagged E.coli His
Human CD8A-10982H Recombinant Human CD8A, GST-tagged E.coli GST 23-183a.a.
Human CD8A-27890TH Recombinant Human CD8A Wheat Germ N/A 110 amino acids
Human CD8A-1158H Recombinant Human CD8a Protein, His-tagged Yeast His
Human CD8A-273H Recombinant Human CD8A protein, His-tagged E.coli His
Human CD8A-274H Recombinant Human CD8A protein, His-tagged E.coli His
Human CD8A-2493HCL Recombinant Human CD8A cell lysate Human Cell N/A
Human CABTT-003MH Mouse Anti-Human CD8A Monoclonal Antibody Mouse N/A
Human CD8A-1461H Recombinant Human CD8A Protein (Ser22-Asp182), N-His tagged E.coli N-His Ser22-Asp182
Human CD8A--1097H Recombinant Human CD8A Protein (Met1-Asp182), HlgG1 Fc-tagged HEK293 HlgG1 Fc Met1-Asp182
Human CD8A-706H Recombinant Human CD8A Protein, His-tagged HEK293F N-His Ser22-Val235
Human CD8A-3090HF Recombinant Full Length Human CD8A Protein, GST-tagged In Vitro Cell Free System GST 235 amino acids
Human CD8A-3274H Recombinant Human CD8A protein(Met1-Asp182), His-tagged, Biotinylated CHO C-His Met1-Asp182
Human CD8A-2675H Recombinant Human CD8A protein, His-SUMO-tagged E.coli His-SUMO 22-182
Human CD8A-133H Recombinant Human CD8A Protein, His-tagged Human cells His
Human CD8A-176H Recombinant Human CD8A Protein, C-His-tagged E.coli C-His
Human CD8A-132H Recombinant Human CD8A Protein, His-tagged Human Cells His
Human CD8A-5302H Recombinant Human CD8A Protein (Met1-Asp182), C-His tagged Mammalian cells C-His Met1-Asp182
Human CD8A-131H Recombinant Human CD8A Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human CD8A-748HFL Recombinant Full Length Human CD8A Protein, N-His-tagged E.coli His
Human CD8A-2494H Recombinant Human CD8A protein, His-tagged E.coli His 23-183 aa
Human CD8A-5303H Recombinant Human CD8A Protein (Met1-Asp182), C-Twin-Strep tagged Mammalian cells C-Twin-Strep Met1-Asp182
Mouse Cd8a-1502M Recombinant Mouse Cd8a protein, His & GST-tagged E.coli His/GST Ala27~Val247 (Accession # P01731)
Mouse Cd8a-2283M Active Recombinant Mouse Cd8a protein, His-tagged HEK293 His Met1-Tyr196
Mouse CD8A-2514MCL Recombinant Mouse CD8A cell lysate Human Cell N/A
Mouse CD8A-822M Recombinant Mouse CD8A Protein (Met1-Tyr196), HlgG1 Fc-tagged HEK293 HlgG1 Fc Met1-Tyr196
Mouse Cd8a-152MG GMP Recombinant Mouse Cd8a protein HEK293 DNA sequence encoding MouseCD8α(UniProtKB/Swiss-Prot: P01731) was expressed with His tag at the C-terminal.
Mouse Cd8a-705M Recombinant Mouse Cd8a Protein, His-tagged E.coli N-His Ala27-Val247
Mouse CD8A-823M Recombinant Mouse CD8A Protein (Met1-Tyr196), His-tagged, Biotinylated HEK293 His Met1-Tyr196
Mouse CD8a-3021M Spleen CD8a protein-coupled magnetic MicroBeads
Rat Cd8a-1503R Recombinant Rat Cd8a protein, His-tagged E.coli His Gly26~Val236 (Accession # P07725)
Rat Cd8a-28R Recombinant Rat Cd8a, Fc tagged Human Cell Fc/His
Rat CD8A-1264R Recombinant Rat CD8A Protein Mammalian Cell His
Rat CD8A-827RCL Recombinant Rat CD8A cell lysate Human Cell N/A
Rat CD8A-922R-B Recombinant Rat CD8A Protein Pre-coupled Magnetic Beads HEK293
Rat CD8A-1974R Recombinant Rat CD8A protein, hFc-tagged HEK293 hFc Met1-Tyr189
Rat CD8A-922R Recombinant Rat CD8A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CD8a-4291M CD8a protein-coupled magnetic MicroBeads
Bovine CD8A-5375B Recombinant Bovine CD8A protein, His-tagged Yeast His 26-189aa
Bovine CD8A-401B Recombinant Bovine CD8A Protein (26-189 aa), His-SUMO-tagged E.coli His/SUMO 26-189 aa
Canis lupus familiaris (Dog) (Canis familiaris) RFL31973CF Recombinant Full Length Dog T-Cell Surface Glycoprotein Cd8 Alpha Chain(Cd8A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-239)
Ctenopharyngodon idella CD8A-0961C Recombinant Ctenopharyngodon idella CD8A Protein (Arg21-Thr160), C-His tagged E.coli C-His Arg21-Thr160
Cynomolgus CD8A-568H Active Recombinant Cynomolgus CD8A protein, His-tagged HEK293 His Asn22-Asp182&Leu22-Pro170
Cynomolgus CD8A--1098C Recombinant Cynomolgus CD8A protein, hFc-tagged HEK293 hFc Met42-Asp223
Felis catus (Cat) (Felis silvestris catus) RFL13864FF Recombinant Full Length Cat T-Cell Surface Glycoprotein Cd8 Alpha Chain(Cd8A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-239)
Ferret CD8A-1021F Recombinant Ferret CD8A protein(Met1-Glu186), His-tagged HEK293 C-His Met1-Glu186
Ferret CD8A-1872FCL Recombinant Ferret CD8A cell lysate Human Cell N/A
Mus musculus (Mouse) RFL36807MF Recombinant Full Length Mouse T-Cell Surface Glycoprotein Cd8 Alpha Chain(Cd8A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (28-247)
Pongo pygmaeus (Bornean orangutan) RFL14608PF Recombinant Full Length Pongo Pygmaeus T-Cell Surface Glycoprotein Cd8 Alpha Chain(Cd8A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-198)
Rattus norvegicus (Rat) RFL27560RF Recombinant Full Length Rat T-Cell Surface Glycoprotein Cd8 Alpha Chain(Cd8A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-236)
Zebrafish CD8A-3719Z Recombinant Zebrafish CD8A Mammalian Cell His
Chicken CD8A-3508C Recombinant Chicken CD8A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CD8A involved in several pathways and played different roles in them. We selected most pathways CD8A participated on our site, such as Cell adhesion molecules (CAMs), Antigen processing and presentation, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD8A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)ESAM;CNTN1A;BLA;CLDN10A;ITGAM;ITGAV;CLDN20;HLA-DQA2;ITGA6
Antigen processing and presentationCTSL1;HLA-DMB;RFXANK;HLA-DPB1;KLRC3;HSPA1L;B2M;HLA-DPA1;HSPA6
Hematopoietic cell lineageMS4A1;GM13305;Kitl;IL1R1;Flt3l;GP1BB;IL3RA;Fcer2a;IL11
T cell receptor signaling pathwayLCK;RAF1;CD3G;NFATC3;PTPN6;Il2;NCK1;DEF6A;CD3E; CD3D
Primary iCD3E;LCK;ORAI1;CD8B;TAP2;UNG;CD3D;BLNK;RFX5
nodeficiencyCD19;CD79A;RAG1;AICDA;IKBKG;ZAP70;BLNK;UNG;TAP2

CD8A has several biochemical functions, for example, MHC class I protein binding, coreceptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD8A itself. We selected most functions CD8A had, and list some proteins which have the same functions with CD8A. You can find most of the proteins on our site.

Function Related Protein
MHC class I protein bindingCD8A;Pilrb1;HLA-E;ATP5A1;CD244;LILRB1;LILRB2;TAPBP;DERL1
coreceptor activityRAMP3;CCR5;CXCR7;CD86;LRP5;CD28;RGMA;RAMP2;LY96
protein bindingPTPRO;CAMSAP1L1;IGFBP2;CTU2;POMGNT1;ZNF593;LCOR;TCF25;ARHGDIG
protein homodimerization activityNBL1;NR0B2;ADRB3;NOS2;SRR;Defa-rs7;GALE;RENBP;PDCD6
protein kinase bindingVDAC1;BORA;GPRC5B;CDKN2C;MAP3K12;CCNB1;ZFP36;PRKRIP1;CDC25B

CD8A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD8A here. Most of them are supplied by our site. Hope this information will be useful for your research of CD8A.

CDK1; q7ckm5_yerpe; y2573_yerpe; CACYBP

Research Area

Related articles

Chen, SH; Lee, LF; et al. Combination of 4-1BB Agonist and PD-1 Antagonist Promotes Antitumor Effector/Memory CD8 T Cells in a Poorly Immunogenic Tumor Model. CANCER IMMUNOLOGY RESEARCH 3:149-160(2015).
Furugaki, K; Cui, L; et al. Intraperitoneal Administration of a Tumor-Associated Antigen SART3, CD40L, and GM-CSF Gene-Loaded Polyplex Micelle Elicits a Vaccine Effect in Mouse Tumor Models. PLOS ONE 9:-(2014).
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