CD8A
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Official Full Name
CD8a molecule
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Overview
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CD8A; CD8a molecule; CD8, CD8 antigen, alpha polypeptide (p32) , T cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 alpha chain; T8 T-cell antigen; T cell co-receptor; OKT8 T-cell antigen; T-cell antigen Leu2; Leu2 T-lymphocyte;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- GMP Proteins
- Chromatography Reagents
- Protein Pre-coupled Magnetic Beads
- Bovine
- Canis lupus familiaris (Dog) (Canis familiaris)
- Chicken
- Ctenopharyngodon idella
- Cynomolgus
- Dog
- Felis catus (Cat) (Felis silvestris catus)
- Ferret
- Golden hamster
- Human
- Mouse
- Mus musculus (Mouse)
- Pongo pygmaeus (Bornean orangutan)
- Rat
- Rattus norvegicus (Rat)
- Ser22-Asp182
- Zebrafish
- C-His-Avi
- CHO
- E.coli
- E.coli expression system
- HEK293
- HEK293F
- Human Cell
- Human cells
- Human Cells
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Mouse
- Wheat Germ
- Yeast
- Biotin
- C
- Twin
- Strep
- Fc
- Flag
- GST
- His
- Avi
- SUMO
- N
- Strep II
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
CD8A involved in several pathways and played different roles in them. We selected most pathways CD8A participated on our site, such as Cell adhesion molecules (CAMs), Antigen processing and presentation, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD8A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | VCAM1;CLDNG;ITGB2;CDH15;CD40;PTPRFB;NTNG1;CD6;LRRC4 |
| Antigen processing and presentation | CD4;HLA-DRB3;RFXAP;KIR3DL2;HLA-DRB1;HSPA2;HLA-DOA;HLA-A;HLA-C |
| Hematopoietic cell lineage | FCGR1A;Fcer2a;CD1D;CD8B;CSF3;CD4;ITGA3;Kitl;CD8B1 |
| T cell receptor signaling pathway | CBL;VAV3;SLA1;PLCG1;MAP2K2;PIK3CA;NRAS;NFKBIE;MAP3K14 |
| Primary i | UNG;CD8B;RAG2;RFXANK;RFX5;IL2RG;TNFRSF13B;CD8A;LCK |
| nodeficiency | ORAI1;RFX5;IL2RG;IL7R;CD8B1;RFXANK;ICOS;ZAP70;CD3E |
CD8A has several biochemical functions, for example, MHC class I protein binding, coreceptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD8A itself. We selected most functions CD8A had, and list some proteins which have the same functions with CD8A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MHC class I protein binding | BCAP31;CD8A;Pilrb1;CD8B;TUBB4B;CD244;PILRB2;ATP5A1;HLA-E |
| coreceptor activity | RGMD;TGFBR3;RAMP1;CCR8;PVRL2;TMIGD2;PVRL1;CD8A;RGMA |
| protein binding | COX5B;ADAT2;TRIM43;ALS2CR11;CASP6;ID2;FGFBP1;EPB41L3;PLOD3 |
| protein homodimerization activity | AXIN1;S100A5;GIPC1;STK25;LRRK2;UGT1A6A;CSF1;PLDN;UGT1A6 |
| protein kinase binding | CALM;PTK2;TRAF6;USP37;TCTN2;CEP68;CDKN2B;GCSAM;GRB2 |
CD8A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD8A here. Most of them are supplied by our site. Hope this information will be useful for your research of CD8A.
CDK1; q7ckm5_yerpe; y2573_yerpe; CACYBP
Research Area
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