CDH5

  • Official Full Name

    cadherin 5, type 2 (vascular endothelium)

  • Overview

    This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined.
  • Synonyms

    CDH5; cadherin 5, type 2 (vascular endothelium); 7B4; CD144; cadherin-5; 7B4 antigen; VE-cadherin; cd144 antigen; endothelial-specific cadherin; vascular endothelial cadherin; cadherin 5, type 2, VE-cadherin (vascular epithelium);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rhesus monkey
  • Sus scrofa (Pig)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Fc Chimera
  • Fc|His
  • GST
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • hFc
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CDH5-501H Active Recombinant Human CDH5 protein, His-tagged HEK293 His Asp48-Gln599
Human CDH5-1696H Recombinant Human Cadherin 5, Type 2 (Vascular Endothelium), Fc-His Mammalian cells His
Human CDH5-31200TH Recombinant Human CDH5 Wheat Germ N/A 100 amino acids
Human CDH5-0991H Recombinant Human CDH5 Protein, GST-Tagged Wheat Germ GST
Human CDH5-3245H Recombinant Human CDH5 protein, His&hFc-tagged HEK293 His&hFc Met1-Gln593
Human CDH5-6862H Recombinant Human CDH5 protein, His & T7-tagged E.coli His/T7 Gly69~Gly391 (Accession # P33151)
Human CDH5-2213HCL Recombinant Human CDH5 cell lysate Human Cell N/A
Human CDH5-3677H Recombinant Human CDH5 protein, GST-tagged E.coli GST 54-241 aa
Human CDH5-3894H Recombinant Human CDH5 protein, His-tagged E.coli His 54-241 aa
Human CDH5-2641H Recombinant Human CDH5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CDH5-0675H Recombinant Human CDH5 Protein (Val68-Thr307), N-His tagged E.coli N-His Val68-Thr307
Human CDH5-003H Recombinant Human CDH5 Protein, C-His-tagged E.coli C-His
Human CDH5-3854H Recombinant Human CDH5 Protein (Met1-Gln593), C-His tagged Mammalian cells C-His Met1-Gln593
Human CDH5-2641H-B Recombinant Human CDH5 Protein Pre-coupled Magnetic Beads HEK293
Mouse CDH5-148M Active Recombinant Mouse CDH5, Fc Chimera Mammalian cells Fc Chimera
Mouse Cdh5-6863M Recombinant Mouse Cdh5 protein, His & T7-tagged E.coli His/T7 Gly67~Gly390 (Accession # P55284)
Mouse Cdh5-364M Recombinant Mouse Cdh5 Protein, His-tagged Insect Cell His
Mouse Cdh5-2284M Recombinant Mouse Cdh5 protein, His-tagged HEK293 His Met1-Ala592
Mouse CDH5-2570MCL Recombinant Mouse CDH5 cell lysate Human Cell N/A
Mouse Cdh5-7173M Recombinant Mouse Cdh5 Protein, His-tagged Insect Cell His 25-599
Mouse CDH5-128M Recombinant Mouse CDH5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CDH5-128M-B Recombinant Mouse CDH5 Protein Pre-coupled Magnetic Beads HEK293
Rat Cdh5-6864R Recombinant Rat Cdh5 protein, His & T7-tagged E.coli His/T7 Gly59~Gly382 (Accession # NP_001100877.1)
Rat Cdh5-8758R Recombinant Rat Cdh5, His tagged Human Cell Fc/His
Rat CDH5-1201RCL Recombinant Rat CDH5 cell lysate Human Cell N/A
Rat CDH5-1145R Recombinant Rat CDH5 protein(Met1-Gln585), His-tagged HEK293 C-His Met1-Gln585
Rhesus monkey CDH5-1574R Recombinant Rhesus Monkey CDH5 Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey CDH5-1573R Recombinant Rhesus Monkey CDH5 Protein HEK293 N/A
Rhesus monkey CDH5-1575R Recombinant Rhesus Monkey CDH5 Protein, hIgG4-tagged HEK293 hIgG4
Homo sapiens (Human) RFL12043HF Recombinant Full Length Human Cadherin-5(Cdh5) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (48-784)
Mus musculus (Mouse) RFL2498MF Recombinant Full Length Mouse Cadherin-5(Cdh5) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (46-784)
Sus scrofa (Pig) RFL7349SF Recombinant Full Length Pig Cadherin-5(Cdh5) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (45-782)
Zebrafish CDH5-1182Z Recombinant Zebrafish CDH5 Mammalian Cell His
Chicken CDH5-5800C Recombinant Chicken CDH5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CDH5 involved in several pathways and played different roles in them. We selected most pathways CDH5 participated on our site, such as Adherens junctions interactions, Cell adhesion molecules (CAMs), Cell junction organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adherens junctions interactionsCDH2;ANG;CTNND1;CDH6;PVRL1A;CDH5;CDH4;CDH7;CDH13
Cell adhesion molecules (CAMs)CLDN11;VTCN1;PVRL2;NRXN2A;CLDN20;NCAM2;NEO1;VCAM1;ITGAM
Cell junction organizationPARVB;JUPA;CDH7;ANG;JUP;CDH18A;CDH10;CDH5;CDH13
Cell-Cell communicationKIRREL3L;PLECA;CTNND1;DST;DCC;CDH2;KIRREL3;NPHS1;LIMS1
Cell-cell junction organizationCLDN3;CDH8;CDH17;CDH12A;CADM2;CDH4;CDH13;CDH9;F11R.2
Leukocyte transendothelial migrationCDC42;TXK;CLDN1;PIK3R2;PIK3CD;MMP9;ITGA4;PIK3R1;ITGB2
S1P2 pathway
Signal TransductionANXA1A;GPR18;TAX1BP1;ARHGAP17A;MYO7A;FMNL3;LIN7B;PRC1;RDH14B

CDH5 has several biochemical functions, for example, beta-catenin binding, calcium ion binding, ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH5 itself. We selected most functions CDH5 had, and list some proteins which have the same functions with CDH5. You can find most of the proteins on our site.

Function Related Protein
beta-catenin bindingSOX9;SMAD3;SMAD7;CARM1;PARK2;TAX1BP3;SLC9A3R1;LZTS2A;EP300
calcium ion bindingEFHD2;ANXA1B;CDH24;PCDH2AA3;PCDH2G16;CALN1;CPNE1;TGM3;TPO
ion channel bindingTCAP;FAM115C;ACTN4;SRC;KCNE2;KCNQ3;SNTA1;DLG1;YWHAQ
protein bindingFTCD;NPPB;NARG2;MYCBP;MATN2;GABPA;PHF16;PARN;RPS6KA2
protein phosphatase bindingDLG4;PPP6R3;MVP;FGF19;GRB2;HSP90B1;PPP6R1;MAP3K5;PIK3R2
receptor bindingSERPINE1;PVR;ASIP;NUDT19;RSPO2;HIST2H3C2;GSDMA2;TMED1;NRG2A

CDH5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH5.

CTNNB1; PARD6A; KDR; PARD3; SHC1; Ctnnd1

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