CDH5
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Official Full Name
cadherin 5, type 2 (vascular endothelium)
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Overview
This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. -
Synonyms
CDH5; cadherin 5, type 2 (vascular endothelium); 7B4; CD144; cadherin-5; 7B4 antigen; VE-cadherin; cd144 antigen; endothelial-specific cadherin; vascular endothelial cadherin; cadherin 5, type 2, VE-cadherin (vascular epithelium);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rhesus monkey
- Sus scrofa (Pig)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- Human Cell
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Fc
- GST
- hIgG4
- His
- Avi
- T7
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | CDH5-501H | Active Recombinant Human CDH5 protein, His-tagged | HEK293 | His | Asp48-Gln599 |
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| Human | CDH5-1696H | Recombinant Human Cadherin 5, Type 2 (Vascular Endothelium), Fc-His | Mammalian cells | His | 1-593 |
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| Human | CDH5-31200TH | Recombinant Human CDH5 | Wheat Germ | Non | 100 amino acids |
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| Human | CDH5-0991H | Recombinant Human CDH5 Protein, GST-Tagged | Wheat Germ | GST |
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| Human | CDH5-3245H | Recombinant Human CDH5 protein, His&hFc-tagged | HEK293 | His&Fc | Met1-Gln593 | |
| Human | CDH5-6862H | Recombinant Human CDH5 protein, His & T7-tagged | E.coli | His&T7 | Gly69~Gly391 |
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| Human | CDH5-2213HCL | Recombinant Human CDH5 cell lysate | Human Cell | Non |
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| Human | CDH5-3677H | Recombinant Human CDH5 protein, GST-tagged | E.coli | GST | 54-241 aa | |
| Human | CDH5-3894H | Recombinant Human CDH5 protein, His-tagged | E.coli | His | 54-241 aa | |
| Human | CDH5-2641H | Recombinant Human CDH5 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Human | CDH5-0675H | Recombinant Human CDH5 Protein (Val68-Thr307), N-His tagged | E.coli | His | Val68-Thr307 |
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| Human | CDH5-003H | Recombinant Human CDH5 Protein, C-His-tagged | E.coli | His |
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| Human | CDH5-3854H | Recombinant Human CDH5 Protein (Met1-Gln593), C-His tagged | Mammalian cells | His | Met1-Gln593 |
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| Human | CDH5-2641H-B | Recombinant Human CDH5 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | CDH5-148M | Active Recombinant Mouse CDH5, Fc Chimera | Mammalian cells | Fc | Asp46-Gln592 |
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| Mouse | Cdh5-6863M | Recombinant Mouse Cdh5 protein, His & T7-tagged | E.coli | His&T7 | Gly67~Gly390 |
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| Mouse | Cdh5-364M | Recombinant Mouse Cdh5 Protein, His-tagged | Insect Cell | His |
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| Mouse | Cdh5-2284M | Recombinant Mouse Cdh5 protein, His-tagged | HEK293 | His | Met1-Ala592 | |
| Mouse | CDH5-2570MCL | Recombinant Mouse CDH5 cell lysate | Human Cell | Non |
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| Mouse | Cdh5-7173M | Recombinant Mouse Cdh5 Protein, His-tagged | Insect Cell | His | 25-599 |
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| Mouse | CDH5-128M | Recombinant Mouse CDH5 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Mouse | CDH5-128M-B | Recombinant Mouse CDH5 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | Cdh5-6864R | Recombinant Rat Cdh5 protein, His & T7-tagged | E.coli | His&T7 | Gly59~Gly382 |
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| Rat | Cdh5-8758R | Recombinant Rat Cdh5, His tagged | Human Cell | His&Fc | Met1-Gln585 |
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| Rat | CDH5-1201RCL | Recombinant Rat CDH5 cell lysate | Human Cell | Non |
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| Rat | CDH5-1145R | Recombinant Rat CDH5 protein(Met1-Gln585), His-tagged | HEK293 | His | Met1-Gln585 |
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| Rhesus monkey | CDH5-1574R | Recombinant Rhesus Monkey CDH5 Protein, hIgG1-tagged | HEK293 | Fc | 28-598 |
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| Rhesus monkey | CDH5-1573R | Recombinant Rhesus Monkey CDH5 Protein | HEK293 | Non | 28-598 |
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| Rhesus monkey | CDH5-1575R | Recombinant Rhesus Monkey CDH5 Protein, hIgG4-tagged | HEK293 | hIgG4 | 28-598 |
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| Homo sapiens (Human) | RFL12043HF | Recombinant Full Length Human Cadherin-5(Cdh5) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (48-784) |
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| Mus musculus (Mouse) | RFL2498MF | Recombinant Full Length Mouse Cadherin-5(Cdh5) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (46-784) |
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| Sus scrofa (Pig) | RFL7349SF | Recombinant Full Length Pig Cadherin-5(Cdh5) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (45-782) |
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| Zebrafish | CDH5-1182Z | Recombinant Zebrafish CDH5 | Mammalian Cell | His |
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| Chicken | CDH5-5800C | Recombinant Chicken CDH5 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
CDH5 involved in several pathways and played different roles in them. We selected most pathways CDH5 participated on our site, such as Adherens junctions interactions, Cell adhesion molecules (CAMs), Cell junction organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adherens junctions interactions | CDH12A;CTNNA1;PTBP3;ANG;CDH12;CDH5;PVRL1A;CDH4;CDH24 |
| Cell adhesion molecules (CAMs) | SDC3;CLDN7B;NLGN1;Itgam&Itgb2;MPZL1;PTPRF;NADL1.2;CLDN15LB;CLDNF |
| Cell junction organization | PLEC;INADL;F11R.2;CDH4;CDH18A;RSU1;PVRL1A;FBLIM1;CDH3 |
| Cell-Cell communication | CADM2;CDH9;CDH8;CDH4;KIRREL2;CDH18A;CLDN3;KIRRELA;COL17A1 |
| Cell-cell junction organization | CDH18;CDH24;CDH6;INADL;CADM2;F11R.2;CLDN23;CTNND1;CDH5 |
| Leukocyte transendothelial migration | JAM2;Itgam&Itgb2;NCF4;CLDN17;NIPAL1;RASSF5;CXCL12;PIK3R5;TXK |
| S1P2 pathway | |
| Signal Transduction | FABP11A;PRICKLE1;WDR35;NMBA;SOX4B;ASH2L;LPAR5A;ARHGAP10;CDC42EP3 |
CDH5 has several biochemical functions, for example, beta-catenin binding, calcium ion binding, ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH5 itself. We selected most functions CDH5 had, and list some proteins which have the same functions with CDH5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-catenin binding | CARM1;APC2;APC;SMAD3;ESR1;VCL;SOX17;PXN;GLI3 |
| calcium ion binding | ITSN2;THBS3A;SNCB;BGLAP-RS1;PCDHGA1;SWAP70;SYT3;MYLPFA;PVALB6 |
| ion channel binding | KCNIP1;KCNJ11;KCNB1;AKAP6;CDH5;AKAP9;CALM2;ID2;YES1 |
| protein binding | PHIP;PPP2R2B;PRELID1;HSD17B10;POP4;SFRS9;THAP7;STAP1;AQP1 |
| protein phosphatase binding | RPA2;CTNNB1;DRD1;KCNN4;ANAPC7;PPP1R3C;STAT3;PIK3R1;SHOC2 |
| receptor binding | FGF13B;PAOX;CADM2A;TNFSF14;F7;PTK2BB;NRTN;FKBP1B;CADM1B |
CDH5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH5.
CTNNB1; PARD6A; KDR; PARD3; SHC1; Ctnnd1
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