CEACAM5
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Official Full Name
carcinoembryonic antigen-related cell adhesion molecule 5
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Overview
CEACAM1 and CEACAM5 belong to the carcinoembryonic antigen (CEA) gene family. It is expressed on cells of epithelial and myeloid origin. CEACAM1 expression is downregulated in many tumors indicating a tumor - suppressive function. The antitumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of antiangiogenic molecules from the cells. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like A (A1, A2) and one B domain. While the N, A1 and B domains can also be found in other CEA-family members, the A2 domain of CEACAM1 differs from those found in other CEACAM. CEACAM5 is a cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. CEACAM5 is a homodimer. It is a receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. -
Synonyms
CEACAM5; carcinoembryonic antigen-related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100; DKFZp781M2392;
- Recombinant Proteins
- Cell & Tissue Lysates
- Transfected Stable Cell Lines
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Cynomolgus
- Human
- Mouse
- Rhesus Macaque
- CHO cells
- E.coli
- HEK293
- HEK293 Cells
- HEK293F
- Human Cell
- Human Cells
- Human Liver Metastasis of Colon Adenocarcinoma
- In Vitro Cell Free System
- Insect Cell
- Insect cells
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- Yeast
- C
- His
- Avi
- LFc
- Fc
- Flag
- GST
- lFc
- N
- MBP
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
CEACAM5 involved in several pathways and played different roles in them. We selected most pathways CEACAM5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CEACAM5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
CEACAM5 has several biochemical functions, for example, GPI anchor binding, identical protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CEACAM5 itself. We selected most functions CEACAM5 had, and list some proteins which have the same functions with CEACAM5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GPI anchor binding | DPEP1;NIPAL1;THY1;CEACAM5;MPPE1;VNN1 |
| identical protein binding | UBE4A;MTPAP;VAMP2;ASMT;G6PDX;MICU1;ADIPOQ;SIAH1;LRRK1 |
| protein homodimerization activity | LDB1;SLIT2;ZFP365;RPS19;KCNN2;TRPM8;CECR1;SH3GLB1;SYNDIG1 |
CEACAM5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CEACAM5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CEACAM5.
c3; llama single domain; draE; CEACAM1; CEACAM6; afaE3; UQCC2
Research Area
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Customer Reviews (3)
Write a reviewCEACAM5 protein has exhibited remarkable performance in Western Blotting experiments.
This enhanced visibility and distinctness of the protein bands greatly aided in the accurate analysis and interpretation of my Western Blotting results.
Its reliability, versatility, and ability to deliver clear and reliable results make it a top choice for researchers in need of a high-quality protein for their experiments.
Q&As (5)
Ask a questionCEACAM5 can be a helpful marker, but it is not typically used for early cancer detection.
CEACAM5 is not specific to a single cancer type and may also be elevated in non-cancerous conditions.
Conditions like hepatitis, pancreatitis, and some non-cancerous gastrointestinal diseases can also elevate CEACAM5 levels.
CEACAM5 levels are monitored to assess the effectiveness of cancer treatment and to detect cancer recurrence.
Yes, CEACAM5 levels can vary between individuals due to genetic factors and other individual-specific variables.
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