CEACAM5

  • Official Full Name

    carcinoembryonic antigen-related cell adhesion molecule 5

  • Overview

    CEACAM1 and CEACAM5 belong to the carcinoembryonic antigen (CEA) gene family. It is expressed on cells of epithelial and myeloid origin. CEACAM1 expression is downregulated in many tumors indicating a tumor - suppressive function. The antitumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of antiangiogenic molecules from the cells. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like A (A1, A2) and one B domain. While the N, A1 and B domains can also be found in other CEA-family members, the A2 domain of CEACAM1 differs from those found in other CEACAM. CEACAM5 is a cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. CEACAM5 is a homodimer. It is a receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
  • Synonyms

    CEACAM5; carcinoembryonic antigen-related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100; DKFZp781M2392;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Human
  • Mouse
  • Rhesus Macaque
  • CHO cells
  • E.coli
  • HEK293
  • HEK293 Cells
  • HEK293F
  • Human Cell
  • Human Cells
  • Human Liver Metastasis of Colon Adenocarcinoma
  • In Vitro Cell Free System
  • Insect Cell
  • Insect cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Yeast
  • C
  • 6×His
  • 6His
  • Avi
  • hFc
  • His
  • DDK
  • DYKDDDDK
  • Fc
  • Fc|His
  • GST
  • His (Fc)
  • His\Avi
  • Llama IgG Fc
  • N/A
  • N
  • MBP
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CEACAM5-87HB Active Recombinant Human CEACAM5 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Lys35-Ala685
Human CEACAM5-051H Active Recombinant Human CEACAM5 protein, Fc/Avi-tagged, Biotinylated CHO cells Fc/Avi Lys35-Ala685
Human CEACAM5-052H Active Recombinant Human CEACAM5 protein, His/Avi-tagged, Biotinylated CHO cells His/Avi Lys35-Ala685
Human CEACAM5-665H Recombinant Human CEACAM5, Fc-His tagged Human Cell Fc/His
Human CEACAM5-1201H Recombinant Human Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 Sf9 Insect Cell N/A
Human CEACAM5-112H Recombinant Human CEACAM5 Protein, His-tagged E.coli His Ala566~Gly698
Human CEACAM5-185H Recombinant Human CEACAM5 protein Insect Cell N/A
Human CEACAM5-3200H Active Recombinant Human CEACAM5 protein(Lys35-Ala685), His-tagged HEK293 His Lys35-Ala685
Human CEACAM5-27800TH Recombinant Human CEACAM5 protein, His-tagged Insect cells His
Human CEACAM5-1203H Recombinant Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 Insect Cell N/A
Human CEACAM5-111H Recombinant Human CEACAM5 Protein, His-tagged E.coli His Pro93~Val221
Human CEACAM5-517H Recombinant Human CEACAM5 protein, His-tagged HEK293F His
Human CEACAM5-1095H Recombinant Human CEACAM5 Protein, GST-Tagged Wheat Germ GST
Human CEACAM5-113H Recombinant Human CEACAM5 Protein, His-tagged E.coli His Gly75~Asn219
Human CEACAM5-114H Recombinant Human CEACAM5 Protein, His-tagged E.coli His Ser448~Gly572
Human CEACAM5-2238HCL Recombinant Human CEACAM5 cell lysate Human Cell N/A
Human CEACAM5-3190H Recombinant Human CEACAM5 Protein, DDK-tagged Insect Cell DDK
Human CEACAM5-1271H Recombinant Human CEACAM5 Protein (Ala34-Leu234), N-His tagged E.coli N-His Ala34-Leu234
Human CEACAM5-151H Recombinant Human CEACAM5 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human CEACAM5-186H Human Carcinoembryonic Antigen Reference standard N/A
Human CEACAM5-27803TH Native Human CEACAM5 Human Liver Metastasis of Colon Adenocarcinoma N/A
Human CEACAM5-015H Recombinant Human CEACAM5 Protein (Lys35-Ala685), C-6×His-tagged HEK293 C-6×His Lys35-Ala685
Human CEACAM5-732H Recombinant Human CEACAM5 Protein, His-tagged E.coli N-His Ser448-Gly572
Human CEACAM5-194H Recombinant Human CEACAM5 Protein, His\Avi-tagged Human Cell His\Avi
Human CEACAM5-2568H Recombinant Human CEACAM5 protein(321-410 aa), C-His-tagged E.coli C-His 321-410 aa
Human CEACAM5-494H Recombinant Human CEACAM5 protein(Met1-Ala685), hFc-tagged HEK293 C-hFc Met1-Ala685
Human CEACAM5-20H Recombinant Human CEACAM5 Protein, C-6His-Avi tagged, Biotinylated Human Cell C-6His-Avi Lys35-Ala685
Human CEACAM5-665HP Recombinant Human CEACAM5 protein, Fc-His-tagged, R-PE labeled HEK293 Fc/His
Human CEACAM5-2569H Recombinant Human CEACAM5 protein(35-685 aa), N-MBP & C-His-tagged HEK293 N-MBP & C-His 35-685 aa
Human CEACAM5-495H Recombinant Human CEACAM5 Protein (Met1-Ala685), His-tagged, Biotinylated HEK293 His Met1-Ala685
Human CEACAM5-22H Recombinant Human CEACAM5 Protein, C-Avi-6His tagged, Biotinylated Human Cell C-Avi-6His Gln38-Asp414
Human CEACAM5-665HA Recombinant Human CEACAM5 protein, Fc-His-tagged, APC labeled HEK293 Fc/His
Human CEACAM5-2570H Recombinant Human CEACAM5 protein(35-685 aa), N-MBP & C-His-tagged HEK293 N-MBP & C-His 35-685 aa
Human CEACAM5-87H Recombinant Human CEACAM5 Protein, His & Avi-Tagged HEK293 His & Avi Lys35-Ala685
Human CEACAM5-3200HAF555 Recombinant Human CEACAM5 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 662
Human CEACAM5-733H Recombinant Human CEACAM5 Protein, His-tagged E.coli N-His Ala566-Gly698
Human CEACAM5-665HAF555 Recombinant Human CEACAM5 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His 899
Human CEACAM5-3200HAF488 Recombinant Human CEACAM5 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 662
Human CEACAM5-3200HAF647 Recombinant Human CEACAM5 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 662
Human CEACAM5-3274HF Recombinant Full Length Human CEACAM5 Protein, GST-tagged In Vitro Cell Free System GST 702 amino acids
Human CEACAM5-665HAF647 Recombinant Human CEACAM5 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His 899
Human CEACAM5-665HAF488 Recombinant Human CEACAM5 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His 899
Human CEACAM5-3200HF Recombinant Human CEACAM5 Protein, His-tagged, FITC conjugated HEK293 His 662
Human CEACAM5-1904H Active Recombinant Human CEACAM5 protein, Llama IgG Fc-tagged HEK293 Llama IgG Fc Pro 593 - Ser 675
Human CEACAM5-665HF Recombinant Human CEACAM5 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His 899
Human CEACAM5-1250H Recombinant Human CEACAM5 protein, His-tagged Yeast His 35-685aa
Mouse Ceacam5-115M Recombinant Mouse Ceacam5 Protein, His-tagged E.coli His Thr85~Phe222
Mouse CEACAM5-3257M Recombinant Mouse CEACAM5 Protein, Fc-tagged HEK293 Cells Fc Gln35-Glu947
Mouse Ceacam5-116M Recombinant Mouse Ceacam5 Protein, His-tagged E.coli His Pro544~Pro771
Mouse Ceacam5-22M Recombinant Mouse Ceacam5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ceacam5-001M Active Recombinant Mouse Ceacam5 Protein, His-tagged Mammalian cells His 35-947
Mouse CEACAM5-3256M Recombinant Mouse CEACAM5 protein, His-tagged HEK293 His Gln 35 - Glu 947
Mouse Ceacam5-22M-B Recombinant Mouse Ceacam5 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ceacam5-002M Active Recombinant Mouse Ceacam5 Protein, Fc-tagged Mammalian cells Fc 35-947
Cynomolgus CEACAM5-5346C Recombinant Cynomolgus CEACAM5 protein, hFc-tagged HEK293 hFc Met1-Ala688
Cynomolgus CEACAM5-1025C Recombinant Cynomolgus CEACAM5 Protein (Met1-Ala688), His-tagged HEK293 His Met1-Ala688
Cynomolgus CEACAM5-2186C Recombinant Cynomolgus CEACAM5 protein, His-tagged HEK293 His Gln 35 - Gly 685
Rhesus Macaque CEACAM5-805R Recombinant Rhesus monkey CEACAM5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CEACAM5-631R-B Recombinant Rhesus Macaque CEACAM5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CEACAM5-631R Recombinant Rhesus Macaque CEACAM5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CEACAM5 involved in several pathways and played different roles in them. We selected most pathways CEACAM5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CEACAM5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

CEACAM5 has several biochemical functions, for example, GPI anchor binding, identical protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CEACAM5 itself. We selected most functions CEACAM5 had, and list some proteins which have the same functions with CEACAM5. You can find most of the proteins on our site.

Function Related Protein
GPI anchor bindingMPPE1;THY1;VNN1;CEACAM5;DPEP1;NIPAL1
identical protein bindingSYT9;GAPDH;APOA1;PLDN;BNIPL;PRDX3;HSPB8;BLOC1S6;RILPL2
protein homodimerization activityFZD1;USF2;DMRTB1;GLA;NR0B1;HELT;NADKD1;CBS;KCNK9

CEACAM5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CEACAM5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CEACAM5.

c3; llama single domain; draE; CEACAM1; CEACAM6; afaE3; UQCC2

Research Area

Related articles

Wakabayashi-Nakao, K; Hatakeyama, K; et al. Carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4) is specifically expressed in medullary thyroid carcinoma cells. BIOMEDICAL RESEARCH-TOKYO 35:237-242(2014).
Bajenova, O; Chaika, N; et al. Carcinoembryonic antigen promotes colorectal cancer progression by targeting adherens junction complexes. EXPERIMENTAL CELL RESEARCH 324:115-123(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can CEACAM5 levels be used to detect cancer in its early stages? 03/28/2021

CEACAM5 can be a helpful marker, but it is not typically used for early cancer detection.

Are there any limitations to using CEACAM5 as a cancer marker? 04/07/2018

CEACAM5 is not specific to a single cancer type and may also be elevated in non-cancerous conditions.

What other medical conditions or diseases can cause an increase in CEACAM5 levels? 02/14/2018

Conditions like hepatitis, pancreatitis, and some non-cancerous gastrointestinal diseases can also elevate CEACAM5 levels.

How is CEACAM5 protein used in cancer treatment monitoring? 12/27/2016

CEACAM5 levels are monitored to assess the effectiveness of cancer treatment and to detect cancer recurrence.

Can CEACAM5 levels vary between different individuals, and if so, why? 12/03/2016

Yes, CEACAM5 levels can vary between individuals due to genetic factors and other individual-specific variables.

Customer Reviews (3)

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Reviews
03/03/2020

    CEACAM5 protein has exhibited remarkable performance in Western Blotting experiments.

    08/06/2019

      This enhanced visibility and distinctness of the protein bands greatly aided in the accurate analysis and interpretation of my Western Blotting results.

      09/23/2018

        Its reliability, versatility, and ability to deliver clear and reliable results make it a top choice for researchers in need of a high-quality protein for their experiments.

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