Active Recombinant Mouse Ceacam5 Protein, Fc-tagged

• Cat.No.: Ceacam5-002M
• Product Overview: Recombinant Mouse CEACAM-5/CD66e (Gln35-Glu947) protein with a Mouse IgG2a (Glu98-Lys330) Fc tag at C-terminus was expressed in Mouse myeloma cell line.

Specification

• Description: Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells.
• Source: Mammalian cells
• Species: Mouse
• Tag: Fc
• Form: Disulfide-linked homodimer
• Bio-activity: Measured by its binding ability in a functional ELISA. When Recombinant Mouse CEACAM-5/CD66e Fc Chimera is immobilized at 0.5 μg/mL (100 μL/well), Recombinant Mouse Galectin-4 binds with an ED50 of 0.1-0.8 μg/mL.
• Molecular Mass: 130 kDa
• Protein length: 35-947
• N-terminal Sequence Analysis: Gln35
• Endotoxin: <0.1 EU/μg of the protein by the LAL method.
• Purity: >90% by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 centigrade as supplied.
  1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
  3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Reconstitution: Reconstitute at 400 μg/mL in PBS.
• Shipping: The product is shipped at ambient temperature.

Gene Information

• Gene Name: Ceacam5 carcinoembryonic antigen-related cell adhesion molecule 5 [ Mus musculus (house mouse) ]
• Official Symbol: Ceacam5
• Synonyms: Ceacam5; carcinoembryonic antigen-related cell adhesion molecule 5; Psg; Psg30; 1600029H12Rik; carcinoembryonic antigen-related cell adhesion molecule 5; pregnancy-specific glycoprotein 30
• Gene ID: 73250
• mRNA Refseq: NM_028480
• Protein Refseq: NP_082756
• UniProt ID: Q3UKK2

Reviews

03/03/2020

CEACAM5 protein has exhibited remarkable performance in Western Blotting experiments.

08/06/2019

This enhanced visibility and distinctness of the protein bands greatly aided in the accurate analysis and interpretation of my Western Blotting results.

09/23/2018

Its reliability, versatility, and ability to deliver clear and reliable results make it a top choice for researchers in need of a high-quality protein for their experiments.

Q&As

Can CEACAM5 levels be used to detect cancer in its early stages?

CEACAM5 can be a helpful marker, but it is not typically used for early cancer detection.

Are there any limitations to using CEACAM5 as a cancer marker?

CEACAM5 is not specific to a single cancer type and may also be elevated in non-cancerous conditions.

What other medical conditions or diseases can cause an increase in CEACAM5 levels?

Conditions like hepatitis, pancreatitis, and some non-cancerous gastrointestinal diseases can also elevate CEACAM5 levels.

How is CEACAM5 protein used in cancer treatment monitoring?

CEACAM5 levels are monitored to assess the effectiveness of cancer treatment and to detect cancer recurrence.

Can CEACAM5 levels vary between different individuals, and if so, why?

Yes, CEACAM5 levels can vary between individuals due to genetic factors and other individual-specific variables.