Recombinant Human CEACAM5 protein, His-tagged

• Cat.No.: CEACAM5-517H

Specification

• Product overview: Recombinant Human CEACAM5 (P06731) fused with His tag was produced in HEK293F cells.
• Description: This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.
• Source: HEK293F
• Species: Human
• Tag: His
• Form: Freeze-dried powder
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: > 97%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: CEACAM5 carcinoembryonic antigen related cell adhesion molecule 5 [ Homo sapiens (human) ]
• Official Symbol: CEACAM5
• Synonyms: CEACAM5; carcinoembryonic antigen related cell adhesion molecule 5; CEA; CD66e; carcinoembryonic antigen-related cell adhesion molecule 5; meconium antigen 100
• Gene ID: 1048
• mRNA Refseq: NM_001291484.2
• Protein Refseq: NP_001278413.1
• UniProt ID: P06731

Reviews

03/03/2020

CEACAM5 protein has exhibited remarkable performance in Western Blotting experiments.

08/06/2019

This enhanced visibility and distinctness of the protein bands greatly aided in the accurate analysis and interpretation of my Western Blotting results.

09/23/2018

Its reliability, versatility, and ability to deliver clear and reliable results make it a top choice for researchers in need of a high-quality protein for their experiments.

Q&As

Can CEACAM5 levels be used to detect cancer in its early stages?

CEACAM5 can be a helpful marker, but it is not typically used for early cancer detection.

Are there any limitations to using CEACAM5 as a cancer marker?

CEACAM5 is not specific to a single cancer type and may also be elevated in non-cancerous conditions.

What other medical conditions or diseases can cause an increase in CEACAM5 levels?

Conditions like hepatitis, pancreatitis, and some non-cancerous gastrointestinal diseases can also elevate CEACAM5 levels.

How is CEACAM5 protein used in cancer treatment monitoring?

CEACAM5 levels are monitored to assess the effectiveness of cancer treatment and to detect cancer recurrence.

Can CEACAM5 levels vary between different individuals, and if so, why?

Yes, CEACAM5 levels can vary between individuals due to genetic factors and other individual-specific variables.