Recombinant Human CEACAM5 Protein, His\Avi-tagged

• Cat.No.: CEACAM5-194H
• Product Overview: Biotinylated Recombinant Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 is produced by our Mammalian expression system and the target gene encoding Lys35-Ala685 is expressed with a Avi, 6His tag at the C-terminus.

Specification

• Description: Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin related glycoproteins. They play critical roles in cell–cell recognition. CEACAM5, also called CEA and CD66e, is characterized by having seven extracellular Ig domains and a glycosylphosphatidylinositol (GPI) anchor. CEACAM5 is expressed primarily by epithelial cells, and functions as a calcium-independent adhesion molecule through homophilic and heterophilic interactions with CEACAM1. Studies have shown that CEACAM5 is overexpressed in a majority of carcinomas, and its overexpression can protect tumor cells from apoptosis. It is commonly used as a cancer marker.
• Source: Human Cells
• Species: Human
• Tag: His&Avi
• Form: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
• AA Sequence: Lys35-Ala685
• Endotoxin: Less than 0.1 ng/ug (1 EU/ug).
• Shipping: Ambient

Gene Information

• Gene Name: CEACAM5 CEA cell adhesion molecule 5 [ Homo sapiens (human) ]
• Official Symbol: CEACAM5
• Synonyms: Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; CEA; Meconium antigen 100; CD66e
• Gene ID: 1048
• mRNA Refseq: NM_001291484.3
• Protein Refseq: NP_001278413.1
• MIM: 114890
• UniProt ID: P06731

Reviews

03/03/2020

CEACAM5 protein has exhibited remarkable performance in Western Blotting experiments.

08/06/2019

This enhanced visibility and distinctness of the protein bands greatly aided in the accurate analysis and interpretation of my Western Blotting results.

09/23/2018

Its reliability, versatility, and ability to deliver clear and reliable results make it a top choice for researchers in need of a high-quality protein for their experiments.

Q&As

Can CEACAM5 levels be used to detect cancer in its early stages?

CEACAM5 can be a helpful marker, but it is not typically used for early cancer detection.

Are there any limitations to using CEACAM5 as a cancer marker?

CEACAM5 is not specific to a single cancer type and may also be elevated in non-cancerous conditions.

What other medical conditions or diseases can cause an increase in CEACAM5 levels?

Conditions like hepatitis, pancreatitis, and some non-cancerous gastrointestinal diseases can also elevate CEACAM5 levels.

How is CEACAM5 protein used in cancer treatment monitoring?

CEACAM5 levels are monitored to assess the effectiveness of cancer treatment and to detect cancer recurrence.

Can CEACAM5 levels vary between different individuals, and if so, why?

Yes, CEACAM5 levels can vary between individuals due to genetic factors and other individual-specific variables.