Active Recombinant Human FCGR3A protein(R167), His-tagged

• Cat.No.: FCGR2A-3548H
• Product Overview: Recombinant Human FCGR3A proteinP08637)(Gln34-Ile218)(Arg167), fused with His tag, was expressed in HEK293.

Specification

• Source: HEK293
• Species: Human
• Tag: His
• Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4.
• Bio-activity: Anti-Human CD19(Tafasitamab ) captured on Protein A chip, can bind Recombinant Human CD32a(R167)/His Protein with a KD constant of 5.19E-08 M, determined in a SPR assay.
• Molecular Mass: The protein has a calculated MW of 22kDa.The reducing (R) heterodimer protein migrates as 25-50 kDa due to glycosylation
• Protein Length: Gln34-Ile218
• Endotoxin: <1EU/mg
• Purity: SDS-PAGE>90%，SEC>95%
• Storage: Store at -20°C.
• Reconstitution: sterile H58O

Gene Information

• Gene Name: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) [ Homo sapiens ]
• Official Symbol: FCGR2A
• Synonyms: FCGR2A; Fc fragment of IgG, low affinity IIa, receptor (CD32); Fc fragment of IgG, low affinity IIa, receptor for (CD32), FCG2, FCGR2, FCGR2A1; low affinity immunoglobulin gamma Fc region receptor II-a; CD32; CD32A; CDw32; IGFR2; Immunoglobulin G Fc receptor II; fcRII-a; fc-gamma-RIIa; fc-gamma RII-a; igG Fc receptor II-a; FCG2; FcGR; FCGR2; FCGR2A1; MGC23887; MGC30032
• Gene ID: 2212
• mRNA Refseq: NM_001136219
• Protein Refseq: NP_001129691
• MIM: 146790
• UniProt ID: P12318

Reviews

03/22/2023

With its purity and reliability, this protein is poised to contribute significantly to the success of my research objectives by providing accurate and reproducible results.

02/26/2023

Its versatility allows for exploration of its extensive involvement in various biochemical and biological processes, providing valuable insights into its role and implications.

07/24/2017

The FCGR2A Protein demonstrates remarkable stability and functional efficiency, making it an indispensable tool for diverse scientific applications.

Q&As

How does FCGR2A impact the risk and severity of certain allergic reactions?

FCGR2A may influence the risk and severity of allergic reactions by modulating the immune response to allergens and antibodies involved in allergic processes.

In the context of infectious diseases, how does FCGR2A contribute to host defense mechanisms?

FCGR2A participates in host defense against infectious diseases by facilitating the recognition and clearance of pathogens through antibody-mediated immune responses.

How does FCGR2A contribute to the understanding of immunogenetics?

FCGR2A contributes to the understanding of immunogenetics by highlighting the genetic factors that influence immune responses and the development of immune-related diseases.

How can genetic variations in FCGR2A impact an individual's response to immunotherapy?

Genetic variations in FCGR2A can influence an individual's response to immunotherapy by affecting the affinity of FCGR2A for antibodies, thereby modulating immune cell activation.

In what ways can FCGR2A be targeted for therapeutic interventions?

FCGR2A can be targeted for therapeutic interventions through the development of drugs that modulate its activity, offering potential strategies for treating immune-related disorders.