Hc

  • Official Full Name

    hemolytic complement

  • Overview

    Mouse Complement 5a (C5a) is a glycoprotein that belongs to a family of structurally and functionally related proteins known as anaphylatoxins. C5a is a 77 amino acid (aa) peptide that is created by the C5a convertase proteolytic cleavage of C5 αchain in the classical and alternative complement pathway (C4b2a3b, C3bBb3b). Mouse C5a has fourαhelices, plus three intrachain disulfide bonds that form a triple loop structure. C5a functions via G-protein coupled receptor (GPCR) (C5aR/CD88). C5a is a potent chemoattractant and anaphylatoxin that acts on all classes of leukocytes and on many other cell types including endothelial, smooth muscle, kidney, liver, and neural cells. It mediates IL-8 release from bronchial epithelial cells. It also triggers an oxidative burst in macrophages and neutrophils, causing release of histamine in basophils and mast cells.C5a anaphylatoxin activity on hepatocytes results indirectly from interaction with nonparenchymal cell via prostanoid secretion. Mouse C5a shares 60% and 82% aa sequence identity to human and rat C5a,respectively.

  • Synonyms

    C5;He;C5a

Recombinant Proteins

  • Mouse
  • Clostridium butyricum
  • Hypoderma lineatum
  • E.coli
  • Mammalian Cells
  • HEK293
  • Non
  • His
  • Fc
  • SUMO
  • Avi
  • Myc

    Involved Pathway

    Hc involved in several pathways and played different roles in them. We selected most pathways Hc participated on our site, such as Complement and coagulation cascades,Prion diseases,Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Hc were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Prion diseases C8B,CASP12,FYN,C5,C1QC,C8A,IL1B,PRKACB,NCAM2,MAP2K1
    Herpes simplex infection C3A.1,THOC4,IL1B,CSNK2A2,ARNTL,BLA,HCFC1B,IFNB1,IFNB,NFKBIB
    Systemic lupus erythematosus HIST1H2BO,HIST1H2BI,HLA-DRA,ACTN1,ACTN4,H2AFB1,HIST1H2AM,HIST1H3G,HIST1H3A,HIST1H2BK
    Staphylococcus aureus infection HLA-DRB3,CFI,HLA-DPB1,FCGR2A,MASP1,H2-AB1,HLA-DMA,ITGB2,FPR3,HLA-DRB5
    Pertussis CD14,GNAI2,GNAI1,IRF1,Casp3,SERPING1,C1R,RELA,ITGB2,CALM4
    Complement and coagulation cascades C8A,SERPIND1,MASP2,VWF,C1S,F3,MASP1,GM5077,C9,FGB

    Protein Function

    Hc has several biochemical functions, for example, endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Hc itself. We selected most functions Hc had, and list some proteins which have the same functions with Hc. You can find most of the proteins on our site.

    Function Related Protein
    endopeptidase inhibitor activity PCSK1N,Cstb,C3A.6,SERPINF2,C3A.3,C3P1,RECK,MUG2,SERPINA1D,SPINK2

    Interacting Protein

    Hc has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Hc here. Most of them are supplied by our site. Hope this information will be useful for your research of Hc.

    C5ar1;C5ar2

    Resources

    References

    • Chen, PC; Syu, GD; et al. Antibody Profiling of Bipolar Disorder Using Escherichia coli Proteome Microarrays. MOLECULAR & CELLULAR PROTEOMICS 14:510-518(2015).
    • Kull, S; Schulz, KM; et al. Isolation and Functional Characterization of the Novel Clostridium botulinum Neurotoxin A8 Subtype. PLOS ONE 10:-(2015).

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