HSP90AA1
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Official Full Name
heat shock protein 90kDa alpha (cytosolic), class A member 1
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Overview
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] -
Synonyms
HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1; EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; HSPCAL1; HSPCAL4; heat shock protein HSP 90-alpha; HSP 86; heat shock 86 kDa; LPS-associated protein 2; heat shock 90kD protein 1, alpha; heat shock 90kDa protein 1, alpha; renal carcinoma antigen NY-REN-38; heat shock 90kD protein, alpha-like 4; epididymis luminal secretory protein 52; heat shock 90kD protein 1, alpha-like 4; lipopolysaccharide-associated protein 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Pig
- Rat
- E. coli
- E.coli
- HEK293
- HEK293T
- HeLa
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Yeast
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- His|MBP
- SUMO
- MYC
- Myc|DDK
- N/A
- N
- 6×His
- Involved Pathway
- Protein Function
- Interacting Protein
- HSP90AA1 Related Research Area
HSP90AA1 involved in several pathways and played different roles in them. We selected most pathways HSP90AA1 participated on our site, such as Protein processing in endoplasmic reticulum, PIK-Akt signaling pathway, Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSP90AA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Protein processing in endoplasmic reticulum | BCAP31;BAG1;DNAJB1A;HSP26;SSR4;UBE2D1;UGGT2;SVIP;GSBP9 |
PIK-Akt signaling pathway | TNXB;ITGA5;FGFR1;PCK2;ITGB8;ANGPT4;CCND2;SGK3;PPP2CB |
Antigen processing and presentation | HSP90AB1;KIR2DL1;KIR2DS4;HSPA1L;RFXAP;CTSB;KLRC1;PSME1;HLA-B |
NOD-like receptor signaling pathway | SGUT1;MAPK8;Ccl12;HSP90AA1;MAP3K7IP3;NFKBIB;NAIP1;TAB2;PSTPIP1B |
Progesterone-mediated oocyte maturation | PIK3CG;FZR1;PIK3CB;PPP1R2P9;CDC23;AKT3A;GNAI1;ANAPC13;CDC25B |
Estrogen signaling pathway | PLCB2;KRAS;PLCB1;SHC3;HSPA1L;GPR30;GABBR1;PRKACG;FKBP4 |
Pathways in cancer | PLCB1;RASSF5;PDGFA;FGF13;CASP9;CTBP2;F2R;Shh;FGF8 |
Prostate cancer | NKX3-1;PIK3R1;Pdgfa&Pdgfb;MTOR;CASP9;BRAF;SRD5A2;TCF7L2;CCNE1 |
HSP90AA1 has several biochemical functions, for example, ATP binding, ATPase activity, GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSP90AA1 itself. We selected most functions HSP90AA1 had, and list some proteins which have the same functions with HSP90AA1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | STK38;ATAD5;RECQL4;MYH1;UBE2G2;TEK;FYNB;MAPK14B;SMC1A |
ATPase activity | ATP13A;HSP90AA1;ABCA5;PSMC5;ABCB6;HSPA1A;KIFC2;SMARCA4A;ABCA4A |
GTPase binding | ENO1;GM5506;YBX1;GNB1;GNB3;LCP1;GOLGA4;STOML2;GNB2 |
MHC class II protein complex binding | HLA-DMB;HSP90AB1;HLA-DRA;HLA-DMA;ATP1B1;HLA-DOB;HSPA8;PKM;HLA-DOA |
TPR domain binding | RAB8B;HSP90AB1;PDE2A;STUB1;HSP90AA1 |
identical protein binding | UAP1;PSMA7;STIM1;BCHE;PPP1R13L;BNIP2;PTK6;TRAF2;PRPF3 |
nitric-oxide synthase regulator activity | CALM3;ESR1;CALM2;HSP90AB1;CALM1;HSP90AA1.1;HSP90AA1;AKT1 |
nucleotide binding | TIA1;ERBB3B;FLJ11011L;EWSR1B;VMHC;BOLL;GNA13A;SRSF2;HNRNPABA |
poly(A) RNA binding | SF1;MAZ;CHD2;SUPT5H;EXOSC9;PTPN1;CNOT4;RPS6;RRP9 |
protein binding | VBP1;NID2;CRABP1;STK36;RAB24;DERL2;PSMA5;BRD2;TRAPPC4 |
protein homodimerization activity | S100A13;PDCD6;TMEM192;ANO2;ATIC;GGCT;GRHPR;PML;GPD1B |
unfolded protein binding | HSPA6;CCT2;DNAJB1A;CALR;HSP90AA1.1;ERLEC1;SIL1;CLGN;CCT4 |
HSP90AA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSP90AA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSP90AA1.
CDC37; STUB1
- Q&As
- Reviews
Q&As (6)
Ask a questionHSP90AA1 proteins can participate in regulating the expression and function of inflammatory factors in the inflammatory process, which has an impact on the occurrence and development of inflammatory diseases.
HSP90AA1 proteins can help immune cells fold and activate some important antigens, participate in the immune response process, and have an impact on tumor immunotherapy.
The expression level of HSP90AA1 protein is upregulated in some tumor cells and can serve as a potential tumor biomarker for tumor diagnosis and monitoring.
There is no clear evidence that HSP90AA1 protein can be used as a therapeutic target for inflammatory diseases, but its regulatory role in the inflammatory process may provide new ideas for the development of related therapeutic strategies.
HSP90AA1 proteins can lead to the occurrence and development of tumor drug resistance by stabilizing and protecting some resistance-related proteins, such as ABC transporters.
Inhibitors targeting HSP90AA1 proteins can be developed to interfere with their interactions with other proteins, affecting the growth and survival of tumor cells.
Customer Reviews (3)
Write a reviewThis powerful biological activity of the protein combined with its high purity makes the experimental results extremely reliable.
Application range of this protein is really wide, from the laboratory to the clinic, can see its figure, it is really rare.
Short half-life and high clearance of recombinant proteins enable them to effectively avoid drug accumulation and side effects, and provide a strong guarantee for patient safety.
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