Recombinant Human HSP90AA1 protein, GST-tagged
Cat.No. : | HSP90AA1-366H |
Product Overview : | Recombinant Human HSP90AA1 protein (Glu535-Asp732), fused to GST tag at N-terminus, was expressed in E.coli. |
- Specification
- Gene Information
- Related Products
Description : | Heat shock protein HSP 90-alpha (HSP90AA1 or HSP90A) is also known as Heat shock 86 kDa (HSP 86 or HSP86), Renal carcinoma antigen NY-REN-38, HSPC1, HSPCA, EL52, HSP89A, HSP90N, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2, which belongs to the heat shock protein 90 family. HSP90AA1 undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. HSP90AA1 interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Form : | Lyophilized from 0.22 um filtered solution in 50 mM HEPES, 150 mM NaCl, pH7.0, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 49.3 kDa. The protein migrates as 49 kDa under reducing (R) condition (SDS-PAGE). |
Protein length : | 198 |
Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
Purity : | >85% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | HSP90AA1 |
Official Symbol : | HSP90AA1 |
Synonyms : | HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock 90kD protein 1, alpha , heat shock 90kDa protein 1, alpha , HSPC1, HSPCA; heat shock protein HSP 90-alpha; FLJ31884; Hsp89; Hsp90; HSP90N; HSP 86; heat shock 86 kDa; heat shock 90kD protein 1, alpha; heat shock 90kDa protein 1, alpha; renal carcinoma antigen NY-REN-38; heat shock 90kD protein, alpha-like 4; heat shock 90kD protein 1, alpha-like 4; HSPN; LAP2; HSP86; HSPC1; HSPCA; HSP89A; HSP90A; HSPCAL1; HSPCAL4 |
Gene ID : | 3320 |
mRNA Refseq : | NM_001017963 |
Protein Refseq : | NP_001017963 |
MIM : | 140571 |
UniProt ID : | P07900 |
Products Types
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HSP90AA1-047H | Recombinant Human HSP90AA1 Protein, N-6×His-tagged | +Inquiry |
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◆ Native Protein | ||
HSP90AA1-14H | Native Hsp90 Protein | +Inquiry |
◆ Lysates | ||
HSP90AA1-5362HCL | Recombinant Human HSP90AA1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionHSP90AA1 proteins can participate in regulating the expression and function of inflammatory factors in the inflammatory process, which has an impact on the occurrence and development of inflammatory diseases.
HSP90AA1 proteins can help immune cells fold and activate some important antigens, participate in the immune response process, and have an impact on tumor immunotherapy.
The expression level of HSP90AA1 protein is upregulated in some tumor cells and can serve as a potential tumor biomarker for tumor diagnosis and monitoring.
There is no clear evidence that HSP90AA1 protein can be used as a therapeutic target for inflammatory diseases, but its regulatory role in the inflammatory process may provide new ideas for the development of related therapeutic strategies.
HSP90AA1 proteins can lead to the occurrence and development of tumor drug resistance by stabilizing and protecting some resistance-related proteins, such as ABC transporters.
Inhibitors targeting HSP90AA1 proteins can be developed to interfere with their interactions with other proteins, affecting the growth and survival of tumor cells.
Customer Reviews (3)
Write a reviewThis powerful biological activity of the protein combined with its high purity makes the experimental results extremely reliable.
Application range of this protein is really wide, from the laboratory to the clinic, can see its figure, it is really rare.
Short half-life and high clearance of recombinant proteins enable them to effectively avoid drug accumulation and side effects, and provide a strong guarantee for patient safety.
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