| Species : |
Mouse |
| Source : |
Mouse |
| Tag : |
His |
| Description : |
Interleukin (IL)-15 is a pleiotropic cytokine that plays a pivotal role in both innate and adaptive immunity and has structural similarity to IL-2 that is secreted by mononuclear phagocytes following infection by viruses. Stimulation by IL-15 requires interaction of Il-15 with components of IL-2R, including IL-2Rbeta and probably IL-2R gamma, but not IL-2R alpha. This cytokine is produced by a wide variety of cells and tissues and like IL-2, stimulates the proliferation of T-lymphocytes and induces the generation of cytotoxic T-lymphocytes (CTLs) and lymphokine-activated killer (LAK) cells. |
| Concentration : |
0.5 mg/ml |
| Form : |
Supplied as a liquid in PBS, pH7.4, containing 10% glycerol. |
| Purity : |
> 90% by SDS - PAGE |
| Sequence : |
49-162 amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMNW IDVRYDLEKI ESLIQSIHID TTLYTDSDFH PSCKVTAMNC FLLELQVILH EYSNMTLNET VRNVLYLANS TLSSNKNVAE SGCKECEELE EKTFTEFLQS FIRIVQMFIN TS |
| Molecular Mass : |
17.6 kDa (152aa), confirmed by MALDI-TOF. |
| Applications : |
SDS-PAGE |
| Endotoxin Levels : |
< 1.0 EU per ug of protein (determined by LAL method) |
| Bioactivity : |
Measured in a cell proliferation assay using CTLL2 mouse cytotoxic T cells. The ED50 for this effect is < 1 ng/ml. |
| Storage : |
Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
