Recombinant Rat Il1r1 protein, His-tagged
|Product Overview :||Recombinant Rat Il1r1 aa. (Val226~Lys352 (Accession # M95578)) fused with N-terminal His tag was produced in E. coli cells.|
- Gene Information
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|Description :||Receptor for interleukin-1; involved in inflammatory response signalling.|
|Source :||E. coli|
|Form :||Freeze-dried powder|
|Molecular Mass :||Predicted Molecular Mass: 16.4kDa|
|Protein length :||Val226~Lys352 (Accession # M95578)|
|Endotoxin :||<1.0EU per 1µg (determined by the LAL method)|
|Purity :||> 95%|
|Characteristic :||The isoelectric point is 6.1.|
|Applications :||SDS-PAGE; WB; ELISA; IP|
|Stability :||The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.|
|Storage :||Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.|
|Storage buffer :||Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl|
|Reconstitution :||Reconstitute in sterile PBS, pH7.2-pH7.4|
|Gene Name :||Il1r1 interleukin 1 receptor type 1 [ Rattus norvegicus (Norway rat) ]|
|Official Symbol :||Il1r1|
|Synonyms :||Il1r1; interleukin 1 receptor type 1; interleukin-1 receptor type 1; CD121 antigen-like family member A; IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1; interleukin 1 beta receptor type 1 short transmembrane form; interleukin 1 beta receptor type 1 soluble form; interleukin 1 bete receptor type 1 long transmembrane form; interleukin-1 receptor alpha; interleukin-1 receptor type I; p80|
|Gene ID :||25663|
|mRNA Refseq :||NM_013123.3|
|Protein Refseq :||NP_037255.3|
|UniProt ID :||Q05KR1|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Live-cell imaging techniques track IL1R1's movement on the cell surface, revealing how cellular localization impacts its responsiveness to ligands.
Advanced computational modeling and molecular dynamics simulations predict allosteric changes in IL1R1's intracellular domain upon ligand binding, revealing insights into its downstream signaling cascade.
FRET and cross-linking assays reveal the multimeric assembly of IL1R1, shedding light on its dimerization and oligomerization dynamics.
Confocal microscopy and flow cytometry visualize IL1R1's endocytosis and recycling, offering insights into its intracellular trafficking dynamics and signaling duration.
Co-immunoprecipitation assays unravel the interactions between IL1R1 and adapter proteins, elucidating the molecular details of its intracellular signaling cascade.
Mutagenesis studies dissect the interfaces between IL1R1 and accessory proteins like IL1RAP, uncovering their roles in ligand binding and signaling modulation.
Cryo-electron microscopy captures IL1R1's structural shifts during ligand binding, unveiling conformational changes that influence its ligand recognition.
Proteomics-based studies uncover the crosstalk between IL1R1 and other receptors in signaling networks, unveiling their interconnected pathways.
CRISPR-based approaches manipulate IL1R1 expression and alternative splicing, providing functional insights into the complex regulatory mechanisms governing its variations.
Phosphoproteomics characterizes IL1R1's phosphorylation landscape, revealing how post-translational modifications shape its downstream signaling outcomes.
Customer Reviews (3)Write a review
High stability. -
Suitable for ELISA. -
Effective in signaling studies. -
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