Active Recombinant Human IL1R1 Protein
Cat.No. : | IL1R1-214H |
Product Overview : | Recombinant Human IL1R1 was expressed in HEK293. |
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Description : | This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. |
Source : | HEK293 |
Species : | Human |
Form : | 1 x PBS |
Bio-activity : | The ED50 is 0.2 - 0.6 µg/ml, corresponding to a specific activity of 1.7 - 5.0 x 10^3 units/mg, determined by the dose dependent inhibition of D10.G4.1 cell proliferation. |
Molecular Mass : | 38 kDa |
Endotoxin : | Less than 0.01 ng per µg protein as determined by the LAL method. |
Purity : | >95%, as determined by Coomassie stained SDS-PAGE. |
Concentration : | Protein formulated and vialed at >50 ug/mL in specified buffer |
Tag : | Non |
Gene Name : | IL1R1 interleukin 1 receptor, type I [ Homo sapiens ] |
Official Symbol : | IL1R1 |
Synonyms : | IL1R1; interleukin 1 receptor, type I; IL1R, IL1RA; interleukin-1 receptor type 1; CD121A; D2S1473; IL-1R-1; IL-1RT1; IL-1RT-1; antigen CD121a; interleukin receptor 1; interleukin-1 receptor alpha; interleukin-1 receptor type I; CD121 antigen-like family member A; interleukin 1 receptor alpha, type I; P80; IL1R; IL1RA; IL-1R-alpha; |
Gene ID : | 3554 |
mRNA Refseq : | NM_000877 |
Protein Refseq : | NP_000868 |
MIM : | 147810 |
UniProt ID : | P14778 |
Products Types
◆ Recombinant Protein | ||
IL1R1-02H | Active Recombinant Human IL1R1 Protein (19-328aa), C-His-tagged | +Inquiry |
IL1R1-064H | Recombinant Human IL1R1 Protein, C-His-tagged | +Inquiry |
IL1R1-3147H | Recombinant Human IL1R1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Il1r1-10581M | Recombinant Mouse Il1r1 Protein, His (Fc)-Avi-tagged | +Inquiry |
IL1R1-164H | Recombinant Human IL1R1 Protein (ECD), His-tagged(C-ter) | +Inquiry |
◆ Lysates | ||
IL1R1-945CCL | Recombinant Cynomolgus IL1R1 cell lysate | +Inquiry |
IL1R1-1120HCL | Recombinant Human IL1R1 cell lysate | +Inquiry |
IL1R1-1935RCL | Recombinant Rat IL1R1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewHigh stability.
Suitable for ELISA.
Effective in signaling studies.
Q&As (10)
Ask a questionLive-cell imaging techniques track IL1R1's movement on the cell surface, revealing how cellular localization impacts its responsiveness to ligands.
Advanced computational modeling and molecular dynamics simulations predict allosteric changes in IL1R1's intracellular domain upon ligand binding, revealing insights into its downstream signaling cascade.
FRET and cross-linking assays reveal the multimeric assembly of IL1R1, shedding light on its dimerization and oligomerization dynamics.
Confocal microscopy and flow cytometry visualize IL1R1's endocytosis and recycling, offering insights into its intracellular trafficking dynamics and signaling duration.
Co-immunoprecipitation assays unravel the interactions between IL1R1 and adapter proteins, elucidating the molecular details of its intracellular signaling cascade.
Mutagenesis studies dissect the interfaces between IL1R1 and accessory proteins like IL1RAP, uncovering their roles in ligand binding and signaling modulation.
Cryo-electron microscopy captures IL1R1's structural shifts during ligand binding, unveiling conformational changes that influence its ligand recognition.
Proteomics-based studies uncover the crosstalk between IL1R1 and other receptors in signaling networks, unveiling their interconnected pathways.
CRISPR-based approaches manipulate IL1R1 expression and alternative splicing, providing functional insights into the complex regulatory mechanisms governing its variations.
Phosphoproteomics characterizes IL1R1's phosphorylation landscape, revealing how post-translational modifications shape its downstream signaling outcomes.
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