Recombinant Human IL1R1 Full Length Transmembrane protein, His-SUMO & Myc-tagged
Cat.No. : | IL1R1-2379H |
Product Overview : | Recombinant Human IL1R1 protein(P14778)(18-569aa), fused to N-terminal His-SUMO tag and C-terminal Myc tag, was expressed in E. coli. |
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Source : | In vitro E. coli expression system |
Species : | Human |
Tag : | His&Myc&SUMO |
Form : | If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Molecular Mass : | 83.5kDa |
Protein length : | 18-569aa |
AA Sequence : | LEADKCKEREEKIILVSSANEIDVR PCPLNPNEHKGTITWYKDDSKTPVS TEQASRIHQHKEKLWFVPAKVEDSG HYYCVVRNSSYCLRIKISAKFVENE PNLCYNAQAIFKQKLPVAGDGGLVC PYMEFFKNENNELPKLQWYKDCKPL LLDNIHFSGVKDRLIVMNVAEKHRG NYTCHASYTYLGKQYPITRVIEFIT LEENKPTRPVIVSPANETMEVDLGS QIQLICNVTGQLSDIAYWKWNGSVI DEDDPVLGEDYYSVENPANKRRSTL ITVLNISEIESRFYKHPFTCFAKNT HGIDAAYIQLIYPVTNFQKHMIGIC VTLTVIIVCSVFIYKIFKIDIVLWY RDSCYDFLPIKASDGKTYDAYILYP KTVGEGSTSDCDIFVFKVLPEVLEK QCGYKLFIYGRDDYVGEDIVEVINE NVKKSRRLIIILVRETSGFSWLGGS SEEQIAMYNALVQDGIKVVLLELEK IQDYEKMPESIKFIKQKHGAIRWSG DFTQGPQSAKTRFWKNVRYHMPVQR RSPSSKHQLLSPATKEKLQREAHVP LG |
Purity : | Greater than 85% as determined by SDS-PAGE. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Reconstitution : | Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. |
Gene Name : | IL1R1 interleukin 1 receptor, type I [ Homo sapiens ] |
Official Symbol : | IL1R1 |
Synonyms : | IL1R1; interleukin 1 receptor, type I; IL1R, IL1RA; interleukin-1 receptor type 1; CD121A; D2S1473; IL-1R-1; IL-1RT1; IL-1RT-1; antigen CD121a; interleukin receptor 1; interleukin-1 receptor alpha; interleukin-1 receptor type I; CD121 antigen-like family member A; interleukin 1 receptor alpha, type I; P80; IL1R; IL1RA; IL-1R-alpha; |
Gene ID : | 3554 |
mRNA Refseq : | NM_000877 |
Protein Refseq : | NP_000868 |
MIM : | 147810 |
UniProt ID : | P14778 |
Products Types
◆ Recombinant Protein | ||
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IL1R1-02H | Active Recombinant Human IL1R1 Protein (19-328aa), C-His-tagged | +Inquiry |
Il1r1-10581M | Recombinant Mouse Il1r1 Protein, His (Fc)-Avi-tagged | +Inquiry |
IL1R1-3147H | Recombinant Human IL1R1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
IL1R1-1787MCL | Recombinant Mouse IL1R1 cell lysate | +Inquiry |
IL1R1-945CCL | Recombinant Cynomolgus IL1R1 cell lysate | +Inquiry |
IL1R1-1120HCL | Recombinant Human IL1R1 cell lysate | +Inquiry |
Related Gene
Not For Human Consumption!
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Customer Reviews (3)
Write a reviewHigh stability.
Suitable for ELISA.
Effective in signaling studies.
Q&As (10)
Ask a questionLive-cell imaging techniques track IL1R1's movement on the cell surface, revealing how cellular localization impacts its responsiveness to ligands.
Advanced computational modeling and molecular dynamics simulations predict allosteric changes in IL1R1's intracellular domain upon ligand binding, revealing insights into its downstream signaling cascade.
FRET and cross-linking assays reveal the multimeric assembly of IL1R1, shedding light on its dimerization and oligomerization dynamics.
Confocal microscopy and flow cytometry visualize IL1R1's endocytosis and recycling, offering insights into its intracellular trafficking dynamics and signaling duration.
Co-immunoprecipitation assays unravel the interactions between IL1R1 and adapter proteins, elucidating the molecular details of its intracellular signaling cascade.
Mutagenesis studies dissect the interfaces between IL1R1 and accessory proteins like IL1RAP, uncovering their roles in ligand binding and signaling modulation.
Cryo-electron microscopy captures IL1R1's structural shifts during ligand binding, unveiling conformational changes that influence its ligand recognition.
Proteomics-based studies uncover the crosstalk between IL1R1 and other receptors in signaling networks, unveiling their interconnected pathways.
CRISPR-based approaches manipulate IL1R1 expression and alternative splicing, providing functional insights into the complex regulatory mechanisms governing its variations.
Phosphoproteomics characterizes IL1R1's phosphorylation landscape, revealing how post-translational modifications shape its downstream signaling outcomes.
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