Active Recombinant Human IL1R1 Protein (19-328aa), C-His-tagged
|Product Overview :||Recombinant human IL1RL1 (19-328aa), fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.|
- Gene Information
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|Description :||The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants.|
|Bio-activity :||Measured by its ability to inhibit proliferation using D10.G4.1 mouse helper T cells. The ED50 range ≤10 ng/mL with Human IL-33.|
|Molecular Mass :||36 kDa (318aa)|
|Protein Length :||19-328|
|AA Sequence :||KFSKQSWGLENEALIVRCPRQGKPS YTVDWYYSQTNKSIPTQERNRVFAS GQLLKFLPAAVADSGIYTCIVRSPT FNRTGYANVTIYKKQSDCNVPDYLM YSTVSGSEKNSKIYCPTIDLYNWTA PLEWFKNCQALQGSRYRAHKSFLVI DNVMTEDAGDYTCKFIHNENGANYS VTATRSFTVKDEQGFSLFPVIGAPA QNEIKEVEIGKNANLTCSACFGKGT QFLAAVLWQLNGTKITDFGEPRIQQ EEGQNQSFSNGLACLDMVLRIADVK EEDLLLQYDCLALNLHGLRRHTVRL SRKNPIDHHS
|Endotoxin :||< 1 EU/μg of protein (determined by LAL method)|
|Purity :||> 95% by SDS-PAGE|
|Applications :||SDS-PAGE, Bioactivity|
|Storage :||Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.|
|Concentration :||0.5 mg/mL (determined by absorbance at 280nm)|
|Storage Buffer :||Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol|
|Gene Name :||IL1RL1 interleukin 1 receptor like 1 [ Homo sapiens (human) ]|
|Official Symbol :||IL1RL1|
|Synonyms :||IL1RL1; interleukin 1 receptor like 1; T1; ST2; DER4; ST2L; ST2V; FIT-1; IL33R; interleukin-1 receptor-like 1; growth stimulation-expressed; homolog of mouse growth stimulation-expressed; interleukin 1 receptor-related protein; EC 22.214.171.124|
|Gene ID :||9173|
|mRNA Refseq :||NM_016232|
|Protein Refseq :||NP_057316|
|UniProt ID :||Q01638|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Live-cell imaging techniques track IL1R1's movement on the cell surface, revealing how cellular localization impacts its responsiveness to ligands.
Advanced computational modeling and molecular dynamics simulations predict allosteric changes in IL1R1's intracellular domain upon ligand binding, revealing insights into its downstream signaling cascade.
FRET and cross-linking assays reveal the multimeric assembly of IL1R1, shedding light on its dimerization and oligomerization dynamics.
Confocal microscopy and flow cytometry visualize IL1R1's endocytosis and recycling, offering insights into its intracellular trafficking dynamics and signaling duration.
Co-immunoprecipitation assays unravel the interactions between IL1R1 and adapter proteins, elucidating the molecular details of its intracellular signaling cascade.
Mutagenesis studies dissect the interfaces between IL1R1 and accessory proteins like IL1RAP, uncovering their roles in ligand binding and signaling modulation.
Cryo-electron microscopy captures IL1R1's structural shifts during ligand binding, unveiling conformational changes that influence its ligand recognition.
Proteomics-based studies uncover the crosstalk between IL1R1 and other receptors in signaling networks, unveiling their interconnected pathways.
CRISPR-based approaches manipulate IL1R1 expression and alternative splicing, providing functional insights into the complex regulatory mechanisms governing its variations.
Phosphoproteomics characterizes IL1R1's phosphorylation landscape, revealing how post-translational modifications shape its downstream signaling outcomes.
Customer Reviews (3)Write a review
High stability. -
Suitable for ELISA. -
Effective in signaling studies. -
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