Active Recombinant Human IL1R1 Protein (19-328aa), C-His-tagged

Cat.No. : IL1R1-02H
Product Overview : Recombinant human IL1RL1 (19-328aa), fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
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Description : The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants.
Source : Baculovirus
Species : Human
Tag : C-His
Form : Liquid
Bio-activity : Measured by its ability to inhibit proliferation using D10.G4.1 mouse helper T cells. The ED50 range ≤10 ng/mL with Human IL-33.
Molecular Mass : 36 kDa (318aa)
Protein Length : 19-328
AA Sequence : KFSKQSWGLENEALIVRCPRQGKPS YTVDWYYSQTNKSIPTQERNRVFAS GQLLKFLPAAVADSGIYTCIVRSPT FNRTGYANVTIYKKQSDCNVPDYLM YSTVSGSEKNSKIYCPTIDLYNWTA PLEWFKNCQALQGSRYRAHKSFLVI DNVMTEDAGDYTCKFIHNENGANYS VTATRSFTVKDEQGFSLFPVIGAPA QNEIKEVEIGKNANLTCSACFGKGT QFLAAVLWQLNGTKITDFGEPRIQQ EEGQNQSFSNGLACLDMVLRIADVK EEDLLLQYDCLALNLHGLRRHTVRL SRKNPIDHHS
Endotoxin : < 1 EU/μg of protein (determined by LAL method)
Purity : > 95% by SDS-PAGE
Applications : SDS-PAGE, Bioactivity
Storage : Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 0.5 mg/mL (determined by absorbance at 280nm)
Storage Buffer : Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Gene Name : IL1RL1 interleukin 1 receptor like 1 [ Homo sapiens (human) ]
Official Symbol : IL1RL1
Synonyms : IL1RL1; interleukin 1 receptor like 1; T1; ST2; DER4; ST2L; ST2V; FIT-1; IL33R; interleukin-1 receptor-like 1; growth stimulation-expressed; homolog of mouse growth stimulation-expressed; interleukin 1 receptor-related protein; EC 3.2.2.6
Gene ID : 9173
mRNA Refseq : NM_016232
Protein Refseq : NP_057316
MIM : 601203
UniProt ID : Q01638

Products Types

◆ Recombinant Protein
IL1R1-164H Recombinant Human IL1R1 Protein (ECD), His-tagged(C-ter) +Inquiry
Il1r1-10581M Recombinant Mouse Il1r1 Protein, His (Fc)-Avi-tagged +Inquiry
IL1R1-064H Recombinant Human IL1R1 Protein, C-His-tagged +Inquiry
IL1R1-3147H Recombinant Human IL1R1 Protein, His (Fc)-Avi-tagged +Inquiry
Il1r1-882R Recombinant Rat Il1r1 protein, His-tagged +Inquiry

See All IL1R1 Recombinant Protein

◆ Lysates
IL1R1-1787MCL Recombinant Mouse IL1R1 cell lysate +Inquiry
IL1R1-1120HCL Recombinant Human IL1R1 cell lysate +Inquiry
IL1R1-1935RCL Recombinant Rat IL1R1 cell lysate +Inquiry

See All IL1R1 Lysates

Related Gene

IL10 IL10RA IL10RB IL11 IL11RA Il11ra1 IL12 IL12A IL12B IL12RB1 IL13 IL13RA1 IL13RA2 IL15 IL15RA IL16 IL17A IL17B Il17c IL17D Il17f IL17RA IL17RD IL18 IL18BP IL18R1 IL18RAP Il19 Il1a IL1B IL1F10 IL1R1 Il1r2 IL1RAP IL1RAPL1 IL1RAPL2 IL1RL1 IL1RL2 Il1rn IL2 Il20 IL20RA IL21 IL21R IL22 IL22RA1 IL22RA2 IL23A IL24 Il25 IL27 IL27RA IL28A Il28b IL29 IL2RA IL2RB Il2rg IL3 IL31 IL32 Il33 Il34 IL3RA IL4 IL4R Il4ra Il5 IL5RA Il6 IL6R Il6ra IL6ST Il7 IL7R IL8 IL9 IL36A Il12rb2 IL17RB IL23R IL26 IL31RA IL36B IL36G IL36RN IL37 IL9R IL17RC IL17RE IL28RA IL4I1 IL20RB Il11ra2 IL7RA Il23a&Il12b

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How does the cellular localization of IL1R1 influence its responsiveness to ligands, and how can live-cell imaging techniques track its dynamic movement on the cell surface? 10/01/2022

Live-cell imaging techniques track IL1R1's movement on the cell surface, revealing how cellular localization impacts its responsiveness to ligands.

How can advanced computational modeling and molecular dynamics simulations predict the allosteric changes in IL1R1's intracellular domain upon ligand binding, offering insights into its downstream signaling cascade? 04/19/2022

Advanced computational modeling and molecular dynamics simulations predict allosteric changes in IL1R1's intracellular domain upon ligand binding, revealing insights into its downstream signaling cascade.

What are the mechanisms underlying IL1R1's dimerization and oligomerization, and how can FRET and cross-linking assays provide insights into its multimeric assembly? 12/26/2020

FRET and cross-linking assays reveal the multimeric assembly of IL1R1, shedding light on its dimerization and oligomerization dynamics.

How does IL1R1's endocytosis and recycling affect its signaling duration, and how can confocal microscopy and flow cytometry unveil its intracellular trafficking patterns? 12/25/2020

Confocal microscopy and flow cytometry visualize IL1R1's endocytosis and recycling, offering insights into its intracellular trafficking dynamics and signaling duration.

What are the intricate molecular details of IL1R1's recruitment of MyD88 and other adapter proteins upon ligand binding, and how can co-immunoprecipitation assays reveal these interactions? 07/25/2020

Co-immunoprecipitation assays unravel the interactions between IL1R1 and adapter proteins, elucidating the molecular details of its intracellular signaling cascade.

How does the interaction between IL1R1 and accessory proteins like IL1RAP influence its ligand binding and intracellular signaling, and how can mutagenesis studies dissect these interfaces? 04/13/2020

Mutagenesis studies dissect the interfaces between IL1R1 and accessory proteins like IL1RAP, uncovering their roles in ligand binding and signaling modulation.

How do the structural dynamics of IL1R1's extracellular domains modulate its binding to various ligands, and how can cryo-electron microscopy unveil these conformational changes? 02/22/2020

Cryo-electron microscopy captures IL1R1's structural shifts during ligand binding, unveiling conformational changes that influence its ligand recognition.

What are the intricate crosstalk mechanisms between IL1R1 and other receptors in cell signaling networks, and how can proteomics-based studies dissect these interconnected pathways? 01/17/2020

Proteomics-based studies uncover the crosstalk between IL1R1 and other receptors in signaling networks, unveiling their interconnected pathways.

What are the complex regulatory mechanisms governing IL1R1's expression and alternative splicing, and how can CRISPR-based approaches shed light on the functional consequences of these variations? 09/09/2018

CRISPR-based approaches manipulate IL1R1 expression and alternative splicing, providing functional insights into the complex regulatory mechanisms governing its variations.

In what ways does IL1R1's post-translational modification landscape impact its downstream signaling, and how can phosphoproteomics offer a comprehensive view of its phosphorylation events? 09/17/2017

Phosphoproteomics characterizes IL1R1's phosphorylation landscape, revealing how post-translational modifications shape its downstream signaling outcomes.

Customer Reviews (3)

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Reviews
07/14/2022

    High stability. -

    06/07/2017

      Suitable for ELISA. -

      04/19/2017

        Effective in signaling studies. -

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