Recombinant Human IL1R1 Protein, C-His-tagged
|Product Overview :
|Recombinant Human IL1R1 Protein with C-His tag was expressed in E. coli.
- Gene Information
- Related Products
|Three structurally related ligands for IL-1Rs have been described. Theseinclude two agonists, IL-1α and IL-1β, and a specific receptor antagonist, IL-1Rα. Among the activities regulated by IL-1 are fever, acute phase responses, degradation of connective tissue and immunostimulatory activities. The IL-1Rα molecule also binds specifically to IL-1Rs, but fails to initiate intracellular responses. Two distinct IL-1Rs have been identified, each of which belongs to the Ig superfamily and is widely expressed in a broad range of cells and tissues. Although many cell types co-express type I and type II receptors, there is no evidence that these constitute subunits of a single complex. The type II receptor has a short 29 amino acid cytoplasmic domain that does not seem sufficient for signaling while in fact there is considerable evidence arguing that IL-1 signals exclusively through the type I IL-1R.
|Molecular Mass :
|AA Sequence :
|LEADKCKEREEKIILVSSANEIDVR PCPLNPNEHKGTITWYKDDSKTPVS TEQASRIHQHKEKLWFVPAKVEDSG HYYCVVRNSSYCLRIKISAKFVENE PNLCYNAQAIFKQKLPVAGDGGLVC PYMEFFKNENNELPKLQWYKDCKPL LLDNIHFSGVKDRLIVMNVAEKHRG NYTCHASYTYLGKQYPITRVIEFIT LEENKPTRPVIVSPANETMEVDLGS QIQLICNVTGQLSDIAYWKWNGSVI DEDDPVLGEDYYSVENPANKRRSTL ITVLNISEIESRFYKHPFTCFAKNT HGIDAAYIQLIYPVTNFQK
|Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
|For research use only, not for use in diagnostic procedure.
|Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
|Storage Buffer :
|PBS, 4M Urea, pH7.4
|Gene Name :
|IL1R1 interleukin 1 receptor, type I [ Homo sapiens (human) ]
|Official Symbol :
|IL1R1; interleukin 1 receptor, type I; IL1R, IL1RA; interleukin-1 receptor type 1; CD121A; D2S1473; IL-1R-1; IL-1RT1; IL-1RT-1; antigen CD121a; interleukin receptor 1; interleukin-1 receptor alpha; interleukin-1 receptor type I; CD121 antigen-like family member A; interleukin 1 receptor alpha, type I; P80; IL1R; IL1RA; IL-1R-alpha;
|Gene ID :
|mRNA Refseq :
|Protein Refseq :
|UniProt ID :
|◆ Recombinant Protein
|Recombinant Human IL1R1 Protein, His (Fc)-Avi-tagged
|Recombinant Mouse Il1r1 Protein, His (Fc)-Avi-tagged
|Active Recombinant Human IL1R1 Protein (19-328aa), C-His-tagged
|Recombinant Human IL1R1 Protein (ECD), His-tagged(C-ter)
|Active Recombinant Mouse Interleukin 1 Receptor, Type I, Fc-tagged
|Recombinant Cynomolgus IL1R1 cell lysate
|Recombinant Human IL1R1 cell lysate
|Recombinant Mouse IL1R1 cell lysate
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Live-cell imaging techniques track IL1R1's movement on the cell surface, revealing how cellular localization impacts its responsiveness to ligands.
Advanced computational modeling and molecular dynamics simulations predict allosteric changes in IL1R1's intracellular domain upon ligand binding, revealing insights into its downstream signaling cascade.
FRET and cross-linking assays reveal the multimeric assembly of IL1R1, shedding light on its dimerization and oligomerization dynamics.
Confocal microscopy and flow cytometry visualize IL1R1's endocytosis and recycling, offering insights into its intracellular trafficking dynamics and signaling duration.
Co-immunoprecipitation assays unravel the interactions between IL1R1 and adapter proteins, elucidating the molecular details of its intracellular signaling cascade.
Mutagenesis studies dissect the interfaces between IL1R1 and accessory proteins like IL1RAP, uncovering their roles in ligand binding and signaling modulation.
Cryo-electron microscopy captures IL1R1's structural shifts during ligand binding, unveiling conformational changes that influence its ligand recognition.
Proteomics-based studies uncover the crosstalk between IL1R1 and other receptors in signaling networks, unveiling their interconnected pathways.
CRISPR-based approaches manipulate IL1R1 expression and alternative splicing, providing functional insights into the complex regulatory mechanisms governing its variations.
Phosphoproteomics characterizes IL1R1's phosphorylation landscape, revealing how post-translational modifications shape its downstream signaling outcomes.
Customer Reviews (3)Write a review
Suitable for ELISA.
Effective in signaling studies.
Ask a Question for All IL1R1 Products
Required fields are marked with *
My Review for All IL1R1 Products
Required fields are marked with *